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Protein Overview: CLD1

General Information:
Name(s) found: CLD1 / YGR110W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 445 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKSTLNSII RRPLKGFQLL RGADSSNTRP QSPRASARDV TEKQILRTPS APTAIPLREI  60
   61 IYRVPSLFPR PLEDSVKDFR DFIKNEDAFQ TELLKTLPFY PTPSESKTAR LIRTVVDDEG 120
  121 NYINEFCIRP RKTSVPEADL KHLVFIHGYG AGLGFFIKNF EDIPLLDNEW CIHAIDLPGY 180
  181 GFSSRPKFPF EYPRDNIHSV QDWFHERIHT WFSKRNLLNR PEKNIVMAHS LGSYLMALYL 240
  241 QKYKESPSFK KLILCSPAGV SYRDFNNTAS EVEKWKPPPW WYVKLWDRNI SPFTLVRNFR 300
  301 QLGSKITSGW SYRRFKHILN GDPEQSKRFE ALHRYAYAIF NKRGSGEYLL SFALKCGGEP 360
  361 RLSLEQQLFD GKKSDILKNS NCDWLWLYGD DDWMDVNGGL RVSRFLKEKL KQKSNVIIVP 420
  421 HSGHHLYLDN YKFFNNILTK EMQKI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..445] PSI-BLAST 51.045757 Epoxide hydrolase, N-terminal domain; Mammalian epoxide hydrolase, C-terminal domain
    2 View Details [85..445] PSI-BLAST 56.221849 Human soluble Epoxide Hydrolase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • catalytic activity
    		•  1.39629727416851 bayes_pls_golite062009
  • phospholipase activity
    		•  1.05835015160042 bayes_pls_golite062009
  • hydrolase activity
    		•  0.889604807785227 bayes_pls_golite062009
  • lipase activity
    		•  0.849473630399459 bayes_pls_golite062009
  • carboxylesterase activity
    		•  0.424330502936163 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.408842908758364 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle