Protein Overview: AML1

General Information:
Name(s) found:	AML1 / YGR001C [SGD]
Description(s) found: Found 23 descriptions. SHOW ALL	Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae [SGD]
Organism:	Saccharomyces cerevisiae
Length:	248 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	biological_process [ND]
Molecular Function:	methyltransferase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSDSDSDY ELTLSANALA ALEEFKREEQ QHQEAFQKLY DETDEDFQKK KKEEGMKLFK  60
   61 EDWQLSQFWY SDDTAAILAD AILEGADENT VIAIVSAPSV YAAIQKKPTN EIPTEHIYLF 120
  121 EFDKRFELLA GRDHFFFYDY NKPLDFSDEI KGKVDRLLID PPFLNEDCQT KSSITAKCLL 180
  181 APNDNSKTKK GVFKHRLISC TGERMSEVIS KVYSDTRITT FLPEHSNGLS NEFRCYANFE 240
  241 CSSWKFAS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	AML1	OAF3	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	AML1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..248]	FFAS03	0.963	Crystal Structure of Putative Methylase from Enterococcus faecalis

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
catalytic activity	1.16970557486814	bayes_pls_golite062009
transferase activity	0.822796502536128	bayes_pls_golite062009
transcription regulator activity	0.612864078793564	bayes_pls_golite062009
DNA binding	0.590883316793444	bayes_pls_golite062009
nucleic acid binding	0.495242738476094	bayes_pls_golite062009
binding	0.439311894979003	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.356820770014331	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.181009652174389	bayes_pls_golite062009
methyltransferase activity	0.165326524526999	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2