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Protein Overview: FEN1

General Information:
Name(s) found: FEN1 / YCR034W [SGD]
Description(s) found:
Found 32 descriptions.
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  • Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 347 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [TASLink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: vesicle-mediated transport [IMPLink to PubMed article]
    fatty acid elongation [IMPLink to PubMed article]
    sphingolipid biosynthetic process [IMPLink to PubMed article]
    Molecular Function: fatty acid elongase activity [IMPLink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSLVTQYAA PLFERYPQLH DYLPTLERPF FNISLWEHFD DVVTRVTNGR FVPSEFQFIA  60
   61 GELPLSTLPP VLYAITAYYV IIFGGRFLLS KSKPFKLNGL FQLHNLVLTS LSLTLLLLMV 120
  121 EQLVPIIVQH GLYFAICNIG AWTQPLVTLY YMNYIVKFIE FIDTFFLVLK HKKLTFLHTY 180
  181 HHGATALLCY TQLMGTTSIS WVPISLNLGV HVVMYWYYFL AARGIRVWWK EWVTRFQIIQ 240
  241 FVLDIGFIYF AVYQKAVHLY FPILPHCGDC VGSTTATFAG CAIISSYLVL FISFYINVYK 300
  301 RKGTKTSRVV KRAHGGVAAK VNEYVNVDLK NVPTPSPSPK PQHRRKR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) FEN1 FKS1 GSC2
    View Details Qiu et al. (2008) FEN1 GPI11 LCB1 SUR4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data FEN1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..347] Pfam 222.19382 GNS1/SUR4 family No confident structure predictions are available.
    2 View Details [143..347] MSA 11.238983 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle