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Protein Overview: SEN34

General Information:
Name(s) found: SEN34 / YAR008W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 275 amino acids

    Gene Ontology:
    Cellular Component: nuclear inner membrane [TASLink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    tRNA-intron endonuclease complex [TASLink to PubMed article]
    mitochondrial outer membrane [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Biological Process: tRNA splicing, via endonucleolytic cleavage and ligation [TASLink to PubMed article]
    Molecular Function: tRNA-intron endonuclease activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPLVFDIDH IKLLRKWGIC GVLSGTLPTA AQQNVFLSVP LRLMLEDVLW LHLNNLADVK  60
   61 LIRQEGDEIM EGITLERGAK LSKIVNDRLN KSFEYQRKFK KDEHIAKLKK IGRINDKTTA 120
  121 EELQRLDKSS NNDQLIESSL FIDIANTSMI LRDIRSDSDS LSRDDISDLL FKQYRQAGKM 180
  181 QTYFLYKALR DQGYVLSPGG RFGGKFIAYP GDPLRFHSHL TIQDAIDYHN EPIDLISMIS 240
  241 GARLGTTVKK LWVIGGVAEE TKETHFFSIE WAGFG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) LOS1 SEN15 SEN2 SEN34 SEN54 STP1 STP2 STP3 STP4 TPT1 TRL1
    View Details Qiu et al. (2008) SEN15 SEN2 SEN34 SEN54 TRL1 TRM1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..149] deduced N/A No confident structure predictions are available.
    2 View Details [150..275] PSI-BLAST 26.045757 tRNA splicing endonuclease, C-terminal domain; tRNA splicing endonuclease EdnA, N-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.41

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle