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Protein Overview: GPPA_ECOLI

General Information:
Name(s) found: GPPA_ECOLI [Swiss-Prot]
Description(s) found:
Found 11 descriptions.
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  • Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC 3.6.1.40) (Guanosine pentaphosphate phosphohydrolase) (pppGpp-5'-phosphohydrolase) - Escherichia coli [Swiss-Prot]
    • Organism: Escherichia coli
    Length: 494 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSTSSLYAA IDLGSNSFHM LVVREVAGSI QTLTRIKRKV RLAAGLNSEN ALSNEAMERG  60
   61 WQCLRLFAER LQDIPPSQIR VVATATLRLA VNAGDFIAKA QEILGCPVQV ISGEEEARLI 120
  121 YQGVAHTTGG ADQRLVVDIG GASTELVTGT GAQTTSLFSL SMGCVTWLER YFADRNLGQE 180
  181 NFDAAEKAAR EVLRPVADEL RYHGWKVCVG ASGTVQALQE IMMAQGMDER ITLEKLQQLK 240
  241 QRAIHCGRLE ELEIDGLTLE RALVFPSGLA ILIAIFTELN IQCMTLAGGA LREGLVYGML 300
  301 HLAVEQDIRS RTLRNIQRRF MIDIDQAQRV AKVAANFFDQ VENEWHLEAI SRDLLISACQ 360
  361 LHEIGLSVDF KQAPQHAAYL VRNLDLPGFT PAQKKLLATL LLNQTNPVDL SSLHQQNAVP 420
  421 PRVAEQLCRL LRLAIIFASR RRDDLVPEMT LQANHELLTL TLPQGWLTQH PLGKEIIAQE 480
  481 SQWQSYVHWP LEVH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..494] PSI-BLAST 110.0 Structure of an E. coli Exopolyphosphatase: Insight into the processive hydrolysis of polyphosphate and its regulation

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • kinase activity
    		•  1.66953112101574 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.48325454573133 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.42990549365307 bayes_pls_golite062009
  • GTP diphosphokinase activity
    		•  1.20625646347886 bayes_pls_golite062009
  • guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
    		•  1.1479499593037 bayes_pls_golite062009
  • diphosphoric monoester hydrolase activity
    		•  1.1479499593037 bayes_pls_golite062009
  • transferase activity
    		•  0.770095506614066 bayes_pls_golite062009
  • polyphosphate kinase activity
    		•  0.7290773631638 bayes_pls_golite062009
  • catalytic activity
    		•  0.666924658593345 bayes_pls_golite062009
  • binding
    		•  0.554867574854209 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  0.431648413805265 bayes_pls_golite062009
  • cyclic-nucleotide phosphodiesterase activity
    		•  0.380631072103095 bayes_pls_golite062009
  • protein binding
    		•  0.298844891785753 bayes_pls_golite062009
  • 3',5'-cyclic-nucleotide phosphodiesterase activity
    		•  0.238185114534071 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle