YRC Public Data Repository - Protein Structure Prediction

Protein:	GPPA_ECOLI
Organism:	Escherichia coli
Length:	494 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GPPA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|227117096, gi... - gi\|99031009\|gb\|ABF61792.1\| exopolyphosphatase [Vibrio cholerae O395], gi\|227117096\|ref\|YP_002818992....	418.0	[0..3]	[493..29]
gi\|75815207 - gi\|75815207\|ref\|ZP_00745728.1\| COG0248: Exopolyphosphatase [Vibrio cholerae V52]	418.0	[0..3]	[493..6]
gi\|229338951, gi... - gi\|229525370\|ref\|ZP_04414775.1\| exopolyphosphatase [Vibrio cholerae bv. albensis VL426], gi\|22933895... gi\|229530145, gi... - gi\|229530145\|ref\|ZP_04419535.1\| exopolyphosphatase [Vibrio cholerae 12129(1)], gi\|229333919\|gb\|EEN99... gi\|229350030, gi... - gi\|229513137\|ref\|ZP_04402603.1\| exopolyphosphatase [Vibrio cholerae TMA 21], gi\|229350030\|gb\|EEO1498... gi\|229344503, gi... - gi\|229517788\|ref\|ZP_04407232.1\| exopolyphosphatase [Vibrio cholerae RC9], gi\|229344503\|gb\|EEO09477.1... gi\|9655165, gi\|1... - gi\|9655165\|gb\|AAF93887.1\| exopolyphosphatase [Vibrio cholerae O1 biovar El Tor str. N16961], gi\|1564... gi\|11266438 - gi\|11266438\|pir\|\|C82289 exopolyphosphatase VC0722 [imported] - Vibrio cholerae (strain N16961 serog... gi\|254285445, gi... - gi\|254285445\|ref\|ZP_04960409.1\| exopolyphosphatase [Vibrio cholerae AM-19226], gi\|197752882\|ref\|YP_0... gi\|148875126, gi... - gi\|153829406\|ref\|ZP_01982073.1\| exopolyphosphatase [Vibrio cholerae 623-39], gi\|148875126\|gb\|EDL7326... gi\|227080901, gi... - gi\|227080901\|ref\|YP_002809452.1\| exopolyphosphatase [Vibrio cholerae M66-2], gi\|227008789\|gb\|ACP0500... gi\|229505662, gi... - gi\|229505662\|ref\|ZP_04395172.1\| exopolyphosphatase [Vibrio cholerae BX 330286], gi\|229357885\|gb\|EEO2...	417.0	[0..3]	[493..29]
gi\|149738993, gi... - gi\|153827127\|ref\|ZP_01979794.1\| exopolyphosphatase [Vibrio cholerae MZO-2], gi\|149738993\|gb\|EDM53305... gi\|116216596, gi... - gi\|75823467\|ref\|ZP_00752966.1\| COG0248: Exopolyphosphatase [Vibrio cholerae RC385], gi\|116216596\|ref... gi\|121590893, gi... - gi\|121590893\|ref\|ZP_01678216.1\| exopolyphosphatase [Vibrio cholerae 2740-80], gi\|121547258\|gb\|EAX573... gi\|124114444, gi... - gi\|153216129\|ref\|ZP_01950284.1\| exopolyphosphatase [Vibrio cholerae 1587], gi\|124114444\|gb\|EAY33264.... gi\|153220741, gi... - gi\|153220741\|ref\|ZP_01951852.1\| exopolyphosphatase [Vibrio cholerae MAK 757], gi\|124120305\|gb\|EAY390... gi\|126510611, gi... - gi\|153818829\|ref\|ZP_01971496.1\| exopolyphosphatase [Vibrio cholerae NCTC 8457], gi\|126510611\|gb\|EAZ7... PPX_VIBCH - Exopolyphosphatase OS=Vibrio cholerae GN=ppx PE=3 SV=2 PPX_VIBCH - Exopolyphosphatase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) GN=ppx P...	417.0	[0..3]	[493..6]
gi\|116188033, gi... - gi\|75829050\|ref\|ZP_00758370.1\| COG0248: Exopolyphosphatase [Vibrio cholerae MO10], gi\|116188033\|ref\|...	415.0	[0..3]	[493..6]
gi\|75819473, gi\|... - gi\|75819473\|ref\|ZP_00749551.1\| COG0248: Exopolyphosphatase [Vibrio cholerae V51], gi\|116220196\|ref\|Z...	415.0	[0..3]	[493..6]
gi\|3452466 - gi\|3452466\|gb\|AAC32884.1\| exopolyphosphatase [Vibrio cholerae]	414.0	[0..3]	[493..6]
GPPA_ERWCT - Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase OS=Erwinia carotovora subsp. atroseptica GN... GPPA_PECAS - Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase OS=Pectobacterium atrosepticum (strain SCRI...	414.0	[0..1]	[491..1]
gi\|237702788, gi... - gi\|237702788\|ref\|ZP_04533269.1\| guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [Escherichi... gi\|91213299, gi\|... - gi\|91213299\|ref\|YP_543285.1\| guanosine pentaphosphate phosphohydrolase [Escherichia coli UTI89], gi\|... gi\|115515164, gi... - gi\|117626040\|ref\|YP_859363.1\| guanosine pentaphosphate phosphohydrolase [Escherichia coli APEC O1], ...	413.0	[0..1]	[494..4]

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Predicted Domain #1

Region A:
Residues: [1-494]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSTSSLYAA IDLGSNSFHM LVVREVAGSI QTLTRIKRKV RLAAGLNSEN ALSNEAMERG  60
   61 WQCLRLFAER LQDIPPSQIR VVATATLRLA VNAGDFIAKA QEILGCPVQV ISGEEEARLI 120
  121 YQGVAHTTGG ADQRLVVDIG GASTELVTGT GAQTTSLFSL SMGCVTWLER YFADRNLGQE 180
  181 NFDAAEKAAR EVLRPVADEL RYHGWKVCVG ASGTVQALQE IMMAQGMDER ITLEKLQQLK 240
  241 QRAIHCGRLE ELEIDGLTLE RALVFPSGLA ILIAIFTELN IQCMTLAGGA LREGLVYGML 300
  301 HLAVEQDIRS RTLRNIQRRF MIDIDQAQRV AKVAANFFDQ VENEWHLEAI SRDLLISACQ 360
  361 LHEIGLSVDF KQAPQHAAYL VRNLDLPGFT PAQKKLLATL LLNQTNPVDL SSLHQQNAVP 420
  421 PRVAEQLCRL LRLAIIFASR RRDDLVPEMT LQANHELLTL TLPQGWLTQH PLGKEIIAQE 480
  481 SQWQSYVHWP LEVH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	110.0
Match:	1u6zA
Description:	Structure of an E. coli Exopolyphosphatase: Insight into the processive hydrolysis of polyphosphate and its regulation
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
kinase activity	1.66953112101574	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.48325454573133	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.42990549365307	bayes_pls_golite062009
GTP diphosphokinase activity	1.20625646347886	bayes_pls_golite062009
guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity	1.1479499593037	bayes_pls_golite062009
diphosphoric monoester hydrolase activity	1.1479499593037	bayes_pls_golite062009
transferase activity	0.770095506614066	bayes_pls_golite062009
polyphosphate kinase activity	0.7290773631638	bayes_pls_golite062009
catalytic activity	0.666924658593345	bayes_pls_golite062009
binding	0.554867574854209	bayes_pls_golite062009
phosphoric diester hydrolase activity	0.431648413805265	bayes_pls_golite062009
cyclic-nucleotide phosphodiesterase activity	0.380631072103095	bayes_pls_golite062009
protein binding	0.298844891785753	bayes_pls_golite062009
3',5'-cyclic-nucleotide phosphodiesterase activity	0.238185114534071	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: