Protein Overview: PHB2

General Information:
Name(s) found:	PHB2 / YGR231C [SGD]
Description(s) found: Found 18 descriptions. SHOW ALL	Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation [SGD]
Organism:	Saccharomyces cerevisiae
Length:	310 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA ] mitochondrial inner membrane [IDA ]
Biological Process:	negative regulation of proteolysis [IMP][IPI] protein folding [IDA][IPI][ISS] replicative cell aging [IMP ]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRSPGEFQR YAKAFQKQLS KVQQTGGRGQ VPSPRGAFAG LGGLLLLGGG ALFINNALFN  60
   61 VDGGHRAIVY SRIHGVSSRI FNEGTHFIFP WLDTPIIYDV RAKPRNVASL TGTKDLQMVN 120
  121 ITCRVLSRPD VVQLPTIYRT LGQDYDERVL PSIVNEVLKA VVAQFNASQL ITQREKVSRL 180
  181 IRENLVRRAS KFNILLDDVS ITYMTFSPEF TNAVEAKQIA QQDAQRAAFV VDKARQEKQG 240
  241 MVVRAQGEAK SAELIGEAIK KSRDYVELKR LDTARDIAKI LASSPNRVIL DNEALLLNTV 300
  301 VDARIDGRGK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ANP1 FKS1 MNN10 MNN11 MNN9 PHB1 PHB2
View Details	Krogan NJ, et al. (2006)		EMP24 ERP1 ERP2 KAR2 PHB2 SCJ1 SSS1 YEL1
View Details	Gavin AC, et al. (2006)		AFG3 PHB2 YTA12

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	MFB1	PHB2	1	Unpublished Fields Lab Data
View Screen	DMC1	PHB2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	PHB2	Huh WK, et al. (2003)

Protein Structure Data

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted