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Protein Overview: unc-30

General Information:
Name(s) found: unc-30 / CE36087 [WormBase]
Description(s) found:
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  • WBGene00006766 locus:unc-30 Homeobox protein unc-30 status:Confirmed UniProt:P52906 protein_id:CAE54882.1 [WormBase]
  • gi|71981647|ref|NP_001021277.1| UNCoordinated family member (unc-30) [Caenorhabditis elegans] [NCBI NR]
  • gi|38422260|emb|CAE54882.1| C. elegans protein B0564.10b, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|114152903|sp|P52906.2|UNC30_CAEEL RecName: Full=Homeobox protein unc-30; AltName: Full=Uncoordinated protein 30 [NCBI NR]
  • Homeobox protein unc-30 OS=Caenorhabditis elegans GN=unc-30 PE=2 SV=2 [Swiss-Prot]
  • [wormpep115.fasta]
  • Hypothetical protein B0564.10b [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE36087 WBGene00006766 locus:unc-30 homeobox protein (otd subfamily) status:Confirmed TR:Q7JLL9 protein_id:CAE54882.1 [wormpep150.fasta]
  • 36087 WBGene00006766 locus:unc-30 homeobox protein (otd subfamily) status:Partially_confirmed TR:Q7JLL9 protein_id:CAE54882.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • CE36087 WBGene00006766 locus:unc-30 homeobox protein (otd subfamily) status:Partially_confirmed TR:Q7JLL9 protein_id:CAE54882.1 [wormpep132.fasta]
  • 36087 WBGene00006766 locus:unc-30 homeobox protein (otd subfamily) status:Confirmed TR:Q7JLL9 protein_id:CAE54882.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • locus:unc-30 homeobox protein (otd subfamily) status:Partially_confirmed TN:CAE54882 protein_id:CAE54882.1 [wormpep115.fasta.reversed]
  • CE36087 WBGene00006766 locus:unc-30 homeobox protein (otd subfamily) status:Confirmed UniProt:UNC30_CAEEL protein_id:CAE54882.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE36087 WBGene00006766 locus:unc-30 homeobox protein (otd subfamily) status:Confirmed UniProt:UNC30_CAEEL protein_id:CAE54882.1| [wormORF-contam.fasta]
  • UNCoordinated family member (unc-30) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Homeobox protein unc-30 (Uncoordinated protein 30) [nr-271106-contam.fasta]
  • CE36087 WBGene00006766 locus:unc-30 homeobox protein (otd subfamily) status:Confirmed SW:P52906 protein_id:CAE54882.1 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta]
  • CE36087 WBGene00006766 locus:unc-30 homeobox protein (otd subfamily) status:Confirmed UniProt:P52906 protein_id:CAE54882.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE36087 WBGene00006766 locus:unc-30 status:Confirmed UniProt:P52906 protein_id:CAE54882.1 Homeobox protein unc-30 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 323 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IEALink to PubMed article]
    Biological Process: regulation of transcription, DNA-dependent [IEALink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: transcription factor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IDALink to PubMed article][IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDNTATLTA IHQQQQSHNR FSNPLVCVGQ LDHHSLLPEH SISSSLAPLT HNPYAFNYSI  60
   61 PLPPTDITTK LPKLELLSLD VKQEQDDNHL DTSSPTDSTG NGSTNGGKIQ KPRRQRTHFT 120
  121 SHQLTELENW FSRNRYPDMA CREEIAVWIS LTEPRVRVWF KNRRAKWRKR ERNYVIDNGQ 180
  181 GTTKVTAQSL DPLGSLQNTF PQTLLQSSSS QLDDSAVTSS SFYGYGGAWQ QNPYYSRNNQ 240
  241 TTFNWQIKPQ DQFQFQTIPM SPTTATSRFS TAANLAPLPT AQAAFSTSAT SSNDKLKLMD 300
  301 GLSNSLSSSL GQPYQPCQYS GPL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..108] deduced N/A No confident structure predictions are available.
    2 View Details [109..180] PSI-BLAST 22.522879 Solution structure of the k50 class homeodomain pitx2 bound to dna and implications for mutations that cause rieger syndrome
    3 View Details [181..323] MSA 7.020997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  3.61657063316558 bayes_pls_golite062009
  • DNA binding
    		•  3.20600447901865 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.13775670276163 bayes_pls_golite062009
  • transcription factor activity
    		•  2.61318050866004 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.14408928200987 bayes_pls_golite062009
  • binding
    		•  2.12643314274039 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.77209608685482 bayes_pls_golite062009
  • transcription activator activity
    		•  1.75864690109096 bayes_pls_golite062009
  • protein binding
    		•  1.62529996900514 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.605733396003465 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.380372494934551 bayes_pls_golite062009
  • chromatin binding
    		•  0.346262410069781 bayes_pls_golite062009
  • transcription factor binding
    		•  0.109547968922689 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle