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View Structure Prediction Details

Protein: unc-30
Organism: Caenorhabditis elegans
Length: 323 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for unc-30.

Description E-value Query
Range
Subject
Range
gi|15823132 - gi|15823132|dbj|BAB68717.1| homeobox protein [Mus spicilegus]
gi|15823120, gi|... - gi|15823128|dbj|BAB68715.1| homeobox protein [Mus musculus], gi|15823126|dbj|BAB68714.1| homeobox pr...
gi|15823118 - gi|15823118|dbj|BAB68710.1| homeobox protein [Mus musculus musculus]
128.0 [0..109] [314..10]

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Predicted Domain #1
Region A:
Residues: [1-108]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDNTATLTA IHQQQQSHNR FSNPLVCVGQ LDHHSLLPEH SISSSLAPLT HNPYAFNYSI  60
   61 PLPPTDITTK LPKLELLSLD VKQEQDDNHL DTSSPTDSTG NGSTNGGK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [109-180]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IQKPRRQRTH FTSHQLTELE NWFSRNRYPD MACREEIAVW ISLTEPRVRV WFKNRRAKWR  60
   61 KRERNYVIDN GQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.522879
Match: 1yz8P
Description: Solution structure of the k50 class homeodomain pitx2 bound to dna and implications for mutations that cause rieger syndrome
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.61657063316558 bayes_pls_golite062009
DNA binding 3.20600447901865 bayes_pls_golite062009
nucleic acid binding 3.13775670276163 bayes_pls_golite062009
transcription factor activity 2.61318050866004 bayes_pls_golite062009
sequence-specific DNA binding 2.14408928200987 bayes_pls_golite062009
binding 2.12643314274039 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.77209608685482 bayes_pls_golite062009
transcription activator activity 1.75864690109096 bayes_pls_golite062009
protein binding 1.62529996900514 bayes_pls_golite062009
transcription repressor activity 0.605733396003465 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.380372494934551 bayes_pls_golite062009
chromatin binding 0.346262410069781 bayes_pls_golite062009
transcription factor binding 0.109547968922689 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [181-323]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTTKVTAQSL DPLGSLQNTF PQTLLQSSSS QLDDSAVTSS SFYGYGGAWQ QNPYYSRNNQ  60
   61 TTFNWQIKPQ DQFQFQTIPM SPTTATSRFS TAANLAPLPT AQAAFSTSAT SSNDKLKLMD 120
  121 GLSNSLSSSL GQPYQPCQYS GPL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle