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View Structure Prediction Details

Protein: unc-30
Organism: Caenorhabditis elegans
Length: 323 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for unc-30.

Description E-value Query
Range
Subject
Range
gi|15823132 - gi|15823132|dbj|BAB68717.1| homeobox protein [Mus spicilegus]
gi|15823120, gi|... - gi|15823128|dbj|BAB68715.1| homeobox protein [Mus musculus], gi|15823126|dbj|BAB68714.1| homeobox pr...
gi|15823118 - gi|15823118|dbj|BAB68710.1| homeobox protein [Mus musculus musculus]
128.0 [0..109] [314..10]

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Predicted Domain #1
Region A:
Residues: [1-108]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDNTATLTA IHQQQQSHNR FSNPLVCVGQ LDHHSLLPEH SISSSLAPLT HNPYAFNYSI  60
   61 PLPPTDITTK LPKLELLSLD VKQEQDDNHL DTSSPTDSTG NGSTNGGK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [109-180]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IQKPRRQRTH FTSHQLTELE NWFSRNRYPD MACREEIAVW ISLTEPRVRV WFKNRRAKWR  60
   61 KRERNYVIDN GQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.522879
Match: 1yz8P
Description: Solution structure of the k50 class homeodomain pitx2 bound to dna and implications for mutations that cause rieger syndrome
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.61657063316558 bayes_pls_golite062009
DNA binding 3.20600447901865 bayes_pls_golite062009
nucleic acid binding 3.13775670276163 bayes_pls_golite062009
transcription factor activity 2.61318050866004 bayes_pls_golite062009
sequence-specific DNA binding 2.14408928200987 bayes_pls_golite062009
binding 2.12643314274039 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.77209608685482 bayes_pls_golite062009
transcription activator activity 1.75864690109096 bayes_pls_golite062009
protein binding 1.62529996900514 bayes_pls_golite062009
transcription repressor activity 0.605733396003465 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.380372494934551 bayes_pls_golite062009
chromatin binding 0.346262410069781 bayes_pls_golite062009
transcription factor binding 0.109547968922689 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [181-323]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTTKVTAQSL DPLGSLQNTF PQTLLQSSSS QLDDSAVTSS SFYGYGGAWQ QNPYYSRNNQ  60
   61 TTFNWQIKPQ DQFQFQTIPM SPTTATSRFS TAANLAPLPT AQAAFSTSAT SSNDKLKLMD 120
  121 GLSNSLSSSL GQPYQPCQYS GPL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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Created and Maintained by: Michael Riffle