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Protein Overview: yrs-1

General Information:
Name(s) found: yrs-1 / CE29515 [WormBase]
Description(s) found:
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  • WBGene00006968 locus:yars-1 status:Confirmed UniProt:H2KZL6 protein_id:CCD68724.1 [WormBase]
  • gi|25145802|ref|NP_741382.1| tYrosinyl tRNA Synthetase family member (yrs-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|15789312|gb|AAB09162.2| Tyrosinyl trna synthetase protein 1, isoform a [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE29515 WBGene00006968 locus:yrs-1 tyrosyl-tRNA synthetase status:Confirmed TR:Q94262 protein_id:AAB09162.2 [wormpep150.fasta]
  • 29515 WBGene00006968 locus:yrs-1 tyrosyl-tRNA synthetase status:Confirmed TR:Q94262 protein_id:AAB09162.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • tYrosinyl tRNA Synthetase (50.1 kD) (yrs-1) [Caenorhabditis elegans]gi|15789312|gb|AAB09162.2| Tyrosinyl trna synthetase protein 1, isoform a [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • locus:yrs-1 tyrosyl-tRNA synthetase status:Confirmed TR:Q94262 protein_id:AAB09162.2 [wormpep115.fasta.reversed]
  • CE29515 locus:yrs-1 tyrosyl-tRNA synthetase status:Confirmed [wormpep80.hongbin]
  • CE29515 WBGene00006968 locus:yrs-1 tyrosyl-tRNA synthetase status:Confirmed UniProt:Q94262_CAEEL protein_id:AAB09162.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE29515 WBGene00006968 locus:yrs-1 tyrosyl-tRNA synthetase status:Confirmed UniProt:Q94262_CAEEL protein_id:AAB09162.2| [wormORF-contam.fasta]
  • Tyrosinyl trna synthetase protein 1, isoform a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • tYrosinyl tRNA Synthetase family member (yrs-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE29515 WBGene00006968 locus:yrs-1 tyrosyl-tRNA synthetase status:Confirmed UniProt:Q94262 protein_id:AAB09162.2 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE29515 WBGene00006968 locus:yars-1 tyrosyl-tRNA synthetase status:Confirmed UniProt:H2KZL6 protein_id:CCD68724.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE29515 WBGene00006968 locus:yars-1 status:Confirmed UniProt:H2KZL6 protein_id:CCD68724.1 [wormpep246-ecoli-contam.fasta]
  • CE29515 WBGene00006968 locus:yars-2 status:Confirmed UniProt:H2KZL6 protein_id:CCD68724.1 Tyrosine--tRNA ligase [c_elegans-PRJNA13758-WS250-ecoli-contam.fasta]
  • Tyrosine--tRNA ligase OS=Caenorhabditis elegans GN=yars-2 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 447 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: tRNA aminoacylation for protein translation [IEALink to PubMed article]
    tyrosyl-tRNA aminoacylation [IEALink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    growth [IMPLink to PubMed article]
    translation [IEALink to PubMed article]
    Molecular Function: nucleotide binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    tyrosine-tRNA ligase activity [IEALink to PubMed article]
    aminoacyl-tRNA ligase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFNSKRIGNV ALKTVRAPRE SSFVDYITDL NARKQLQHSY PTDLLSKCSE DLRQLPPYVY  60
   61 AGFDPTAESL HIGNLLILVN LIRAQQFGIR PIALIGEFTA SIGDPSGKKS ERGLLAGDVI 120
  121 MHNSRKVTDQ ICKIFENAPG SSEKPIIVNN NDWLGKISLR DFLRECKNMQ VGKMLRMNTI 180
  181 KNRLEVGLSY TEFSYQTMQA FDWYTLSEKY GCRFQLGGYD QLGHLDFGAH YIKKMMNQAF 240
  241 AAGVCFPILT DSTGAKLGKS EGGGALWLDA TKTSPFHFYQ FFAQLHDDKA EELLLLFSLQ 300
  301 DIEHIRDVLK NHRSNLGQWI AQRELAAEIT RIVHGKEGLE VAMRCTKAMF GAKKADLSGL 360
  361 SRSEVLQLFR TTIDLKKENV ATMGQLADAS RLGSGKGHLL MQQGAFSVNG EKKRSPSESI 420
  421 ADVFLENASD LTLVCWGKRG YQLVRWV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..447] PSI-BLAST 114.0 STRUCTURE OF TYROSYL-T/RNA SYNTHETASE REFINED AT 2.3 ANGSTROMS RESOLUTION. INTERACTION OF THE ENZYME WITH THE TYROSYL ADENYLATE INTERMEDIATE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ligase activity, forming carbon-oxygen bonds
    		•  7.16276509815667 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  7.16276509815667 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  7.13957775963187 bayes_pls_golite062009
  • tyrosine-tRNA ligase activity
    		•  6.18775771640881 bayes_pls_golite062009
  • ligase activity
    		•  6.11211476973434 bayes_pls_golite062009
  • glutamate-tRNA ligase activity
    		•  2.63681738794687 bayes_pls_golite062009
  • methionine-tRNA ligase activity
    		•  2.56893064485672 bayes_pls_golite062009
  • catalytic activity
    		•  2.37674226834122 bayes_pls_golite062009
  • arginine-tRNA ligase activity
    		•  1.50161401062914 bayes_pls_golite062009
  • tryptophan-tRNA ligase activity
    		•  1.14187887833901 bayes_pls_golite062009
  • cysteine-tRNA ligase activity
    		•  0.844943947059557 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.625793556381714 bayes_pls_golite062009
  • binding
    		•  0.485102284225571 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.449504767632354 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.2293846471193 bayes_pls_golite062009
  • glutamine-tRNA ligase activity
    		•  0.118292082006187 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle