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Protein Overview: akt-2

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

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No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data


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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#   Region(s) Method Confidence Match Description
1 View Details [1..173] PSI-BLAST 21.522879 Solution Structure of the Pleckstrin Homology Domain of Human Protein Kinase B beta (Pkb/Akt)
2 View Details [174..423] PSI-BLAST 53.39794 Crystal Structure Of The Human P21-Activated Kinase 6
3 View Details [424..483] FFAS03 2.36 Structure of cAMP-dependent protein kinase complexed with Isoquinoline-5-sulfonic acid (2-(2-(4-chlorobenzyloxy)ethylamino) ethyl)amide

Functions predicted (by domain):

# Gene Ontology predictions
1
Term Confidence Notes
  • actin binding
  • 3.72754591832642 bayes_pls_golite062009
  • cytoskeletal protein binding
  • 3.48744511411671 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
  • 3.3707139031954 bayes_pls_golite062009
  • binding
  • 3.29080729281876 bayes_pls_golite062009
  • protein binding
  • 3.17213698546013 bayes_pls_golite062009
  • insulin receptor binding
  • 2.87341016128079 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
  • 2.84482185829578 bayes_pls_golite062009
  • profilin binding
  • 2.77241328262501 bayes_pls_golite062009
  • transcription regulator activity
  • 2.10584700564436 bayes_pls_golite062009
  • actin filament binding
  • 2.03444575838575 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
  • 1.8384977631304 bayes_pls_golite062009
  • DNA binding
  • 1.77960272183811 bayes_pls_golite062009
  • GTPase regulator activity
  • 1.66986263418539 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
  • 1.64990514605397 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase signaling protein activity
  • 1.56969272757764 bayes_pls_golite062009
  • signal transducer activity
  • 1.55319485371003 bayes_pls_golite062009
  • molecular transducer activity
  • 1.55319485371003 bayes_pls_golite062009
  • nucleic acid binding
  • 1.55295906221034 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
  • 1.53043443218632 bayes_pls_golite062009
  • kinase activity
  • 1.49733072352288 bayes_pls_golite062009
  • SH2 domain binding
  • 1.41526564231882 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
  • 1.36365892826676 bayes_pls_golite062009
  • protein kinase activity
  • 1.34246406302496 bayes_pls_golite062009
  • transporter activity
  • 1.28986800087234 bayes_pls_golite062009
  • small GTPase regulator activity
  • 1.2550809703725 bayes_pls_golite062009
  • enzyme regulator activity
  • 1.25381967078645 bayes_pls_golite062009
  • receptor activity
  • 1.1755016270537 bayes_pls_golite062009
  • enzyme binding
  • 1.17212675145623 bayes_pls_golite062009
  • phosphatidylinositol-3,4-bisphosphate binding
  • 1.15025513961661 bayes_pls_golite062009
  • transmembrane receptor activity
  • 1.1152029796159 bayes_pls_golite062009
  • phospholipid binding
  • 1.09683218092034 bayes_pls_golite062009
  • Ran GTPase binding
  • 1.07023555877478 bayes_pls_golite062009
  • transferase activity
  • 1.05502123133116 bayes_pls_golite062009
  • receptor binding
  • 1.00859318603128 bayes_pls_golite062009
  • receptor signaling protein activity
  • 1.00400540041137 bayes_pls_golite062009
  • kinase binding
  • 0.961706066143 bayes_pls_golite062009
  • protein domain specific binding
  • 0.90578029954417 bayes_pls_golite062009
  • small GTPase binding
  • 0.8507658747425 bayes_pls_golite062009
  • GTPase binding
  • 0.82889812790119 bayes_pls_golite062009
  • substrate-specific transporter activity
  • 0.79883446648737 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
  • 0.745321902095093 bayes_pls_golite062009
  • phosphoinositide binding
  • 0.71817045430443 bayes_pls_golite062009
  • protein kinase binding
  • 0.67284191028382 bayes_pls_golite062009
  • protein serine/threonine kinase activity
  • 0.611829373978789 bayes_pls_golite062009
  • protein complex binding
  • 0.55916857709427 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase docking protein activity
  • 0.47238283185104 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
  • 0.470521479239198 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
  • 0.391864697086635 bayes_pls_golite062009
  • structural constituent of cytoskeleton
  • 0.35466574267734 bayes_pls_golite062009
  • hydrolase activity
  • 0.354215977182915 bayes_pls_golite062009
  • beta-amyloid binding
  • 0.34714857141225 bayes_pls_golite062009
  • structural molecule activity
  • 0.320527491838187 bayes_pls_golite062009
  • G-protein-coupled receptor binding
  • 0.12466518799375 bayes_pls_golite062009
  • alpha-catenin binding
  • 0.102004310679969 bayes_pls_golite062009
  • pyrophosphatase activity
  • 0.0611639610381174 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
  • 0.0524559849408587 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
  • 0.0498422520006935 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.




    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)


    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle