| Protein: | akt-2 |
| Organism: | Caenorhabditis elegans |
| Length: | 483 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for akt-2.
| Description | E-value | Query Range |
Subject Range |
|
|
420.0 | [0..11] | [481..16] |
|
Region A: Residues: [1-173] |
1 11 21 31 41 51
| | | | | |
1 MSTENAHLQK EDIVIESWLH KKGEHIRNWR PRYFILFRDG TLLGFRSKPK EDQPLPEPLN 60
61 NFMIRDAATV CLDKPRPNMF IVRCLQWTTV IERTFYADSA DFRQMWIEAI QAVSSHNRLK 120
121 ENAGNTSMQE EDTNGNPSGE SDVNMDATST RSDNDFESTV MNIDEPEEVP RKN
|
| Detection Method: |  |
| Confidence: | 21.522879 |
| Match: | 1p6sA |
| Description: | Solution Structure of the Pleckstrin Homology Domain of Human Protein Kinase B beta (Pkb/Akt) |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| actin binding | 3.72754591832642 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 3.48744511411671 | bayes_pls_golite062009 |
| insulin-like growth factor receptor binding | 3.3707139031954 | bayes_pls_golite062009 |
| binding | 3.29080729281876 | bayes_pls_golite062009 |
| protein binding | 3.17213698546013 | bayes_pls_golite062009 |
| insulin receptor binding | 2.87341016128079 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 2.84482185829578 | bayes_pls_golite062009 |
| profilin binding | 2.77241328262501 | bayes_pls_golite062009 |
| transcription regulator activity | 2.10584700564436 | bayes_pls_golite062009 |
| actin filament binding | 2.03444575838575 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 1.8384977631304 | bayes_pls_golite062009 |
| DNA binding | 1.77960272183811 | bayes_pls_golite062009 |
| GTPase regulator activity | 1.66986263418539 | bayes_pls_golite062009 |
| nucleoside-triphosphatase regulator activity | 1.64990514605397 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase signaling protein activity | 1.56969272757764 | bayes_pls_golite062009 |
| signal transducer activity | 1.55319485371003 | bayes_pls_golite062009 |
| molecular transducer activity | 1.55319485371003 | bayes_pls_golite062009 |
| nucleic acid binding | 1.55295906221034 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.53043443218632 | bayes_pls_golite062009 |
| kinase activity | 1.49733072352288 | bayes_pls_golite062009 |
| SH2 domain binding | 1.41526564231882 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.36365892826676 | bayes_pls_golite062009 |
| protein kinase activity | 1.34246406302496 | bayes_pls_golite062009 |
| transporter activity | 1.28986800087234 | bayes_pls_golite062009 |
| small GTPase regulator activity | 1.2550809703725 | bayes_pls_golite062009 |
| enzyme regulator activity | 1.25381967078645 | bayes_pls_golite062009 |
| receptor activity | 1.1755016270537 | bayes_pls_golite062009 |
| enzyme binding | 1.17212675145623 | bayes_pls_golite062009 |
| phosphatidylinositol-3,4-bisphosphate binding | 1.15025513961661 | bayes_pls_golite062009 |
| transmembrane receptor activity | 1.1152029796159 | bayes_pls_golite062009 |
| phospholipid binding | 1.09683218092034 | bayes_pls_golite062009 |
| Ran GTPase binding | 1.07023555877478 | bayes_pls_golite062009 |
| transferase activity | 1.05502123133116 | bayes_pls_golite062009 |
| receptor binding | 1.00859318603128 | bayes_pls_golite062009 |
| receptor signaling protein activity | 1.00400540041137 | bayes_pls_golite062009 |
| kinase binding | 0.961706066143 | bayes_pls_golite062009 |
| protein domain specific binding | 0.90578029954417 | bayes_pls_golite062009 |
| small GTPase binding | 0.8507658747425 | bayes_pls_golite062009 |
| GTPase binding | 0.82889812790119 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.79883446648737 | bayes_pls_golite062009 |
| guanyl-nucleotide exchange factor activity | 0.745321902095093 | bayes_pls_golite062009 |
| phosphoinositide binding | 0.71817045430443 | bayes_pls_golite062009 |
| protein kinase binding | 0.67284191028382 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 0.611829373978789 | bayes_pls_golite062009 |
| protein complex binding | 0.55916857709427 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase docking protein activity | 0.47238283185104 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 0.470521479239198 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 0.391864697086635 | bayes_pls_golite062009 |
| structural constituent of cytoskeleton | 0.35466574267734 | bayes_pls_golite062009 |
| hydrolase activity | 0.354215977182915 | bayes_pls_golite062009 |
| beta-amyloid binding | 0.34714857141225 | bayes_pls_golite062009 |
| structural molecule activity | 0.320527491838187 | bayes_pls_golite062009 |
| G-protein-coupled receptor binding | 0.12466518799375 | bayes_pls_golite062009 |
| alpha-catenin binding | 0.102004310679969 | bayes_pls_golite062009 |
| pyrophosphatase activity | 0.0611639610381174 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides | 0.0524559849408587 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 0.0498422520006935 | bayes_pls_golite062009 |
|
Region A: Residues: [174-423] |
1 11 21 31 41 51
| | | | | |
1 TVTMDDFDFL KVLGQGTFGK VILCREKSSD KLYAIKIIRK EMVVDRSEVA HTLTENRVLY 60
61 ACVHPFLTLL KYSFQAQYHI CFVMEFANGG ELFTHLQRCK TFSEARTRFY GSEIILALGY 120
121 LHHRNIVYRD MKLENLLLDR DGHIKITDFG LCKEEIKYGD KTSTFCGTPE YLAPEVIEDI 180
181 DYDRSVDWWG VGVVMYEMMC GRLPFSAKEN GKLFELITTC DLKFPNRLSP EAVTLLSGLL 240
241 ERVPAKRLGA
|
| Detection Method: | |
| Confidence: | 53.39794 |
| Match: | 2c30A |
| Description: | Crystal Structure Of The Human P21-Activated Kinase 6 |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [424-483] |
1 11 21 31 41 51
| | | | | |
1 GPDDAREVSR AEFFKDVDWE ATLRKEVEPP FKPNVMSETD TSFFDRVRYV SILLKVSEAI 60
61
|
| Detection Method: | |
| Confidence: | 2.36 |
| Match: | 2c1aA |
| Description: | Structure of cAMP-dependent protein kinase complexed with Isoquinoline-5-sulfonic acid (2-(2-(4-chlorobenzyloxy)ethylamino) ethyl)amide |
Matching Structure (courtesy of the PDB): |
|
