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Protein Overview: akt-2

General Information:
Name(s) found: akt-2 / CE29298 [WormBase]
Description(s) found:
Found 23 descriptions.
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  • WBGene00000103 locus:akt-2 Serine\/threonine-protein kinase akt-2 status:Confirmed UniProt:Q9XTG7 protein_id:CAC70087.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 483 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IDALink to PubMed article]
    Biological Process: dauer larval development [IMPLink to PubMed article]
    insulin receptor signaling pathway [IMPLink to PubMed article]
    determination of adult lifespan [IMPLink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article][ISSLink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTENAHLQK EDIVIESWLH KKGEHIRNWR PRYFILFRDG TLLGFRSKPK EDQPLPEPLN  60
   61 NFMIRDAATV CLDKPRPNMF IVRCLQWTTV IERTFYADSA DFRQMWIEAI QAVSSHNRLK 120
  121 ENAGNTSMQE EDTNGNPSGE SDVNMDATST RSDNDFESTV MNIDEPEEVP RKNTVTMDDF 180
  181 DFLKVLGQGT FGKVILCREK SSDKLYAIKI IRKEMVVDRS EVAHTLTENR VLYACVHPFL 240
  241 TLLKYSFQAQ YHICFVMEFA NGGELFTHLQ RCKTFSEART RFYGSEIILA LGYLHHRNIV 300
  301 YRDMKLENLL LDRDGHIKIT DFGLCKEEIK YGDKTSTFCG TPEYLAPEVI EDIDYDRSVD 360
  361 WWGVGVVMYE MMCGRLPFSA KENGKLFELI TTCDLKFPNR LSPEAVTLLS GLLERVPAKR 420
  421 LGAGPDDARE VSRAEFFKDV DWEATLRKEV EPPFKPNVMS ETDTSFFDRV RYVSILLKVS 480
  481 EAI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..173] PSI-BLAST 21.522879 Solution Structure of the Pleckstrin Homology Domain of Human Protein Kinase B beta (Pkb/Akt)
    2 View Details [174..423] PSI-BLAST 53.39794 Crystal Structure Of The Human P21-Activated Kinase 6
    3 View Details [424..483] FFAS03 2.36 Structure of cAMP-dependent protein kinase complexed with Isoquinoline-5-sulfonic acid (2-(2-(4-chlorobenzyloxy)ethylamino) ethyl)amide

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • actin binding
    		•  3.72754591832642 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.48744511411671 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  3.3707139031954 bayes_pls_golite062009
  • binding
    		•  3.29080729281876 bayes_pls_golite062009
  • protein binding
    		•  3.17213698546013 bayes_pls_golite062009
  • insulin receptor binding
    		•  2.87341016128079 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  2.84482185829578 bayes_pls_golite062009
  • profilin binding
    		•  2.77241328262501 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.10584700564436 bayes_pls_golite062009
  • actin filament binding
    		•  2.03444575838575 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.8384977631304 bayes_pls_golite062009
  • DNA binding
    		•  1.77960272183811 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.66986263418539 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.64990514605397 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase signaling protein activity
    		•  1.56969272757764 bayes_pls_golite062009
  • signal transducer activity
    		•  1.55319485371003 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.55319485371003 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.55295906221034 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.53043443218632 bayes_pls_golite062009
  • kinase activity
    		•  1.49733072352288 bayes_pls_golite062009
  • SH2 domain binding
    		•  1.41526564231882 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.36365892826676 bayes_pls_golite062009
  • protein kinase activity
    		•  1.34246406302496 bayes_pls_golite062009
  • transporter activity
    		•  1.28986800087234 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.2550809703725 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.25381967078645 bayes_pls_golite062009
  • receptor activity
    		•  1.1755016270537 bayes_pls_golite062009
  • enzyme binding
    		•  1.17212675145623 bayes_pls_golite062009
  • phosphatidylinositol-3,4-bisphosphate binding
    		•  1.15025513961661 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.1152029796159 bayes_pls_golite062009
  • phospholipid binding
    		•  1.09683218092034 bayes_pls_golite062009
  • Ran GTPase binding
    		•  1.07023555877478 bayes_pls_golite062009
  • transferase activity
    		•  1.05502123133116 bayes_pls_golite062009
  • receptor binding
    		•  1.00859318603128 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.00400540041137 bayes_pls_golite062009
  • kinase binding
    		•  0.961706066143 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.90578029954417 bayes_pls_golite062009
  • small GTPase binding
    		•  0.8507658747425 bayes_pls_golite062009
  • GTPase binding
    		•  0.82889812790119 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.79883446648737 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.745321902095093 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.71817045430443 bayes_pls_golite062009
  • protein kinase binding
    		•  0.67284191028382 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.611829373978789 bayes_pls_golite062009
  • protein complex binding
    		•  0.55916857709427 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase docking protein activity
    		•  0.47238283185104 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.470521479239198 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.391864697086635 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.35466574267734 bayes_pls_golite062009
  • hydrolase activity
    		•  0.354215977182915 bayes_pls_golite062009
  • beta-amyloid binding
    		•  0.34714857141225 bayes_pls_golite062009
  • structural molecule activity
    		•  0.320527491838187 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  0.12466518799375 bayes_pls_golite062009
  • alpha-catenin binding
    		•  0.102004310679969 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0611639610381174 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0524559849408587 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0498422520006935 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle