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Protein Overview: lsd2

General Information:
Name(s) found: lsd2 / SPAC23E2.02 [Sanger Pombe]
Description(s) found:
Found 20 descriptions.
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  • histone demethylase SWIRM2 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 1273 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article][TASLink to PubMed article]
    Lsd1/2 complex [IDALink to PubMed article]
    nuclear chromatin [ICLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: chromatin remodeling [ISSLink to PubMed article]
    cellular response to heat [IEPLink to PubMed article]
    negative regulation of transcription, DNA-dependent [ICLink to PubMed article]
    positive regulation of transcription, DNA-dependent [IMPLink to PubMed article]
    regulation of meiosis [IMPLink to PubMed article]
    histone H3-K9 demethylation [IMPLink to PubMed article]
    Molecular Function: DNA binding [IEA]
    histone demethylase activity (H3-monomethyl-K4 specific) [NAS]
    transcription corepressor activity [ISSLink to PubMed article]
    nucleosome binding [IDALink to PubMed article]
    histone demethylase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLGRSSWIC CAKYFVNTKS RFNEILPPRF TLIVSFYSMN TSENDPDGHY DFPEMTEHHS  60
   61 DRASSYANAN NVNSTQPQLV SSEQALLAIL GGGLQSITPN SVNQNAYSRS TYRTDGGLNS 120
  121 QPVSSLNNQW GNYNPAFLPS RYDSSFHPYT ISQAANQPFP QHLLGNSNAG VAQQSGMRTI 180
  181 GLPPTVGSSF PQQKSSTYEN FFDANSPSSQ QFPSTYPSRS QNPLSSSGDG STAIHAGPIQ 240
  241 HQNSNAFSNY PYPLDASHLS SQQLLSMYRD QVSHGVTPST FRNHESFMPT QLVSATELSK 300
  301 SVDNAVLPIP PTTAPAVVSP PASSFPLMSS AATSGNISSP ALFDSELGAR PEGSVAIEPS 360
  361 RVLLQWSSQS SSHTIPSAGA SIPTSSLKSF FEHAAEAARK CNLDPRALES FEQHMLSDRL 420
  421 HDPVVLFHYF QIRNSICWLW IKNPTHAISR VEAQGVCVDR CLFQLASLAY EFLVRYGYIN 480
  481 YGCLSFDSSF TNETNTGTTS SSASKQKTIA VVGAGLTGLI CARQLTGLFS QYSSSFLSKN 540
  541 ELPPKVIILE AKERTGGRIY SRALPVSHTS ATQINHHTSN SNSISSNSTS LNPKDVTDPS 600
  601 HIPSAIDLGF QFLFSPMDDI LLNLLNKQLG IEVTEMTGSD LVYDETDTKV LDMVEVKKLN 660
  661 ILWEKLLEYV SVCFFINVEE SVRISWISQF QLFIDEMFPD HLSKSLSLNA SHEFSFKKTM 720
  721 LILIDEVSSY AKLGNSQKKF LIWCFKVAEL DDTLYPLNTV DTDFSKDILI PKVARRGLSQ 780
  781 LPWALQSYPS PLNIHYEKFV SKVTIENDKC TLDCKDNSSY EVDQVVIACS PSHFSSNIEF 840
  841 SPGLPNFVTE NIKSIDFKPG KKVILRYAAA FWRKNIRSFG IIPKSLSQEM NNDENDGKSC 900
  901 FVLRIWNMLP ETGVPILVAD INPQMTSSSS NETSHLIQEL HSLIVDHFQN DSNSSADLLD 960
  961 AWVTNWSRNG VYDGLNSYPN FANDKQQYEK RFRQSQLSYN LGRLHIAGDY IFSCVGCRTL1020
 1021 QRSFLSGLSV CTGIIDSLAP ISLTIPIIGE TSRKELDQFL RNSKVNNFDP NAEAQRHLSY1080
 1081 QARYRLKKQE RLDEHKEEQE QLVTELLGYL PEPPSKPNAN PFLLYQKMQW HVCRALADED1140
 1141 KRRLTGDSTA KATINETRAK LGKTWRQLDD LGKKPWIDEI AAQREAYAGK ILRYQRLTKE1200
 1201 YEMRAEQIRN DYAAKCQDEP IPDDEARLFM QAQREEEQRK QTQDDNISKS REASDEEYHD1260
 1261 DGSSDSGYNG TRY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..210] MSA 3.310996 View MSA. No confident structure predictions are available.
    2 View Details [211..378] MSA 5.320996 View MSA. No confident structure predictions are available.
    3 View Details [379..1050] PSI-BLAST 160.0 No description for 2v1dA was found.
    4 View Details [1051..1273] PSI-BLAST 23.045757 No description for 2gzkA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • DNA binding
    		•  5.15324651287773 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.01228762819617 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.9607192917135 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  4.06355503548774 bayes_pls_golite062009
  • transcription factor activity
    		•  3.82658263870186 bayes_pls_golite062009
  • binding
    		•  3.6211482127468 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.17018042329608 bayes_pls_golite062009
  • transcription activator activity
    		•  2.95665802871704 bayes_pls_golite062009
  • protein binding
    		•  2.18211240370246 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.84606709725198 bayes_pls_golite062009
  • transcription factor binding
    		•  1.10315330167937 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.02057566176202 bayes_pls_golite062009
  • chromatin binding
    		•  0.996049314969019 bayes_pls_golite062009
  • DNA bending activity
    		•  0.87985209274756 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.426897554228699 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.4255419067266 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle