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View Structure Prediction Details

Protein: lsd2
Organism: Schizosaccharomyces pombe
Length: 1273 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lsd2.

Description E-value Query
Range
Subject
Range
gi|42553873, gi|... - gi|46124997|ref|XP_387052.1| hypothetical protein FG06876.1 [Gibberella zeae PH-1], gi|42553873|gb|E...
736.0 [0..226] [1268..794]
gi|85091419 - gi|85091419|ref|XP_958892.1| hypothetical protein NCU09120 [Neurospora crassa OR74A]
gi|32422137, gi|... - gi|32422137|ref|XP_331512.1| hypothetical protein [Neurospora crassa], gi|28920283|gb|EAA29656.1| co...
728.0 [0..3] [1266..41]
gi|39965127, gi|... - gi|39965127|ref|XP_365070.1| hypothetical protein MGG_09915 [Magnaporthe grisea 70-15], gb|EAA46694....
706.0 [0..123] [1256..37]
lsd1 - histone demethylase SWIRM1
LSD1_SCHPO - Lysine-specific histone demethylase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=lsd1...
645.0 [0..259] [1242..14]
gi|49092512, gi|... - gi|67526245|ref|XP_661184.1| hypothetical protein AN3580.2 [Aspergillus nidulans FGSC A4], ref|XP_40...
623.0 [0..327] [1243..100]
gi|116181978, gi... - gi|88185914|gb|EAQ93382.1| hypothetical protein CHGG_01617 [Chaetomium globosum CBS 148.51], gi|1161...
607.0 [0..289] [1185..22]
gi|70993368, gi|... - gi|70993368|ref|XP_751531.1| lysine-specific histone demethylase Aof2 [Aspergillus fumigatus Af293],...
605.0 [0..244] [1230..27]
gi|115389710, gi... - gi|115389710|ref|XP_001212360.1| conserved hypothetical protein [Aspergillus terreus NIH2624], gi|11...
596.0 [0..295] [1267..14]
gi|83764623 - gi|83764623|dbj|BAE54767.1| unnamed protein product [Aspergillus oryzae]
gi|169764595 - gi|169764595|ref|XP_001816769.1| hypothetical protein [Aspergillus oryzae RIB40]
gi|220690775, gi... - gi|238504144|ref|XP_002383304.1| lysine-specific histone demethylase Aof2, putative [Aspergillus fla...
580.0 [0..327] [1224..131]
gi|119192506, gi... - gi|90305645|gb|EAS35276.1| hypothetical protein CIMG_00630 [Coccidioides immitis RS], gi|119192506|r...
568.0 [0..277] [1219..91]

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Predicted Domain #1
Region A:
Residues: [1-210]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLGRSSWIC CAKYFVNTKS RFNEILPPRF TLIVSFYSMN TSENDPDGHY DFPEMTEHHS  60
   61 DRASSYANAN NVNSTQPQLV SSEQALLAIL GGGLQSITPN SVNQNAYSRS TYRTDGGLNS 120
  121 QPVSSLNNQW GNYNPAFLPS RYDSSFHPYT ISQAANQPFP QHLLGNSNAG VAQQSGMRTI 180
  181 GLPPTVGSSF PQQKSSTYEN FFDANSPSSQ 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [211-378]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QFPSTYPSRS QNPLSSSGDG STAIHAGPIQ HQNSNAFSNY PYPLDASHLS SQQLLSMYRD  60
   61 QVSHGVTPST FRNHESFMPT QLVSATELSK SVDNAVLPIP PTTAPAVVSP PASSFPLMSS 120
  121 AATSGNISSP ALFDSELGAR PEGSVAIEPS RVLLQWSSQS SSHTIPSA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [379-1050]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GASIPTSSLK SFFEHAAEAA RKCNLDPRAL ESFEQHMLSD RLHDPVVLFH YFQIRNSICW  60
   61 LWIKNPTHAI SRVEAQGVCV DRCLFQLASL AYEFLVRYGY INYGCLSFDS SFTNETNTGT 120
  121 TSSSASKQKT IAVVGAGLTG LICARQLTGL FSQYSSSFLS KNELPPKVII LEAKERTGGR 180
  181 IYSRALPVSH TSATQINHHT SNSNSISSNS TSLNPKDVTD PSHIPSAIDL GFQFLFSPMD 240
  241 DILLNLLNKQ LGIEVTEMTG SDLVYDETDT KVLDMVEVKK LNILWEKLLE YVSVCFFINV 300
  301 EESVRISWIS QFQLFIDEMF PDHLSKSLSL NASHEFSFKK TMLILIDEVS SYAKLGNSQK 360
  361 KFLIWCFKVA ELDDTLYPLN TVDTDFSKDI LIPKVARRGL SQLPWALQSY PSPLNIHYEK 420
  421 FVSKVTIEND KCTLDCKDNS SYEVDQVVIA CSPSHFSSNI EFSPGLPNFV TENIKSIDFK 480
  481 PGKKVILRYA AAFWRKNIRS FGIIPKSLSQ EMNNDENDGK SCFVLRIWNM LPETGVPILV 540
  541 ADINPQMTSS SSNETSHLIQ ELHSLIVDHF QNDSNSSADL LDAWVTNWSR NGVYDGLNSY 600
  601 PNFANDKQQY EKRFRQSQLS YNLGRLHIAG DYIFSCVGCR TLQRSFLSGL SVCTGIIDSL 660
  661 APISLTIPII GE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 160.0
Match: 2v1dA
Description: No description for 2v1dA was found.

Predicted Domain #4
Region A:
Residues: [1051-1273]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSRKELDQFL RNSKVNNFDP NAEAQRHLSY QARYRLKKQE RLDEHKEEQE QLVTELLGYL  60
   61 PEPPSKPNAN PFLLYQKMQW HVCRALADED KRRLTGDSTA KATINETRAK LGKTWRQLDD 120
  121 LGKKPWIDEI AAQREAYAGK ILRYQRLTKE YEMRAEQIRN DYAAKCQDEP IPDDEARLFM 180
  181 QAQREEEQRK QTQDDNISKS REASDEEYHD DGSSDSGYNG TRY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.045757
Match: 2gzkA
Description: No description for 2gzkA was found.

Predicted functions:

Term Confidence Notes
DNA binding 5.15324651287773 bayes_pls_golite062009
nucleic acid binding 5.01228762819617 bayes_pls_golite062009
transcription regulator activity 4.9607192917135 bayes_pls_golite062009
sequence-specific DNA binding 4.06355503548774 bayes_pls_golite062009
transcription factor activity 3.82658263870186 bayes_pls_golite062009
binding 3.6211482127468 bayes_pls_golite062009
transcription repressor activity 3.17018042329608 bayes_pls_golite062009
transcription activator activity 2.95665802871704 bayes_pls_golite062009
protein binding 2.18211240370246 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.84606709725198 bayes_pls_golite062009
transcription factor binding 1.10315330167937 bayes_pls_golite062009
structure-specific DNA binding 1.02057566176202 bayes_pls_golite062009
chromatin binding 0.996049314969019 bayes_pls_golite062009
DNA bending activity 0.87985209274756 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.426897554228699 bayes_pls_golite062009
specific transcriptional repressor activity 0.4255419067266 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle