Protein Overview: arg11

General Information:
Name(s) found:	arg11 / SPAC4G9.09c [Sanger Pombe]
Description(s) found: Found 19 descriptions. SHOW ALL	N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase [Sanger Pombe]
Organism:	Schizosaccharomyces pombe
Length:	885 amino acids
Gene Ontology:
Cellular Component:	mitochondrial matrix [IDA] mitochondrion [IDA]
Biological Process:	arginine biosynthetic process [IGI] ornithine biosynthetic process [ISS] phosphorylation [IC]
Molecular Function:	ATP binding [IEA] N-acetyl-gamma-glutamyl-phosphate reductase activity [IGI] NAD or NADH binding [IEA] acetylglutamate kinase activity [IGI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLIELQQIVK SGLVRNGAKH CTKRSLLCSN ASVIASKRFQ GSFAPGQQQP LNPLAKPIEQ  60
   61 DRDAIIRILS SIGSRREVEQ YLRYFTSFEA QRFAIIKVGG AIITDELDTL AQSLAFLNHV 120
  121 GLYPIVVHGA GPQLNKILAS RNVEPEYSDG IRITDAETLS VARKVFLEEN AKLVDALEKL 180
  181 GTRARPITGG VFQAEYLDKE KYKYVGKIVK VNKAPIEHSI RAGTLPILTS MAETASGQLL 240
  241 NVNADITAGE LARVLKPLKV VYLNEKGGLI NGETKKKISS IYLDREYDGL MKQPWVKYGT 300
  301 KLKIKEIKEL LDTLPRTSSV AIISTKDLQK ELFTESGAGT LISRGFVINK HDSLDSIPDA 360
  361 ALENLIIQKN SLAAPSESLK QFKDTLKDRK LRIYSDSFNE SVAIVDTTDS SLPVLLAFGA 420
  421 ADNNWLNNVV DSILTTLKAD FPSLLWRLQP SAKNLEWFFS KSEGTLFANN FYYFWYGVKD 480
  481 LNKISKFIQS DKPFADAIIQ TQSTKPPTAS STTNNPSSSQ INQKRSYSTS SLFSKNKKMN 540
  541 RSLFLKGGKR FFSAEAQKTQ KPLKAVSSKP AKVVLLGARG YTGKNLIGLI NTHPYLELSH 600
  601 VSSRELEGTK LPGYTKKEIQ YVNLSTDDVK KLEEEGAVDA WVMALPNGVC KPYVDALTSA 660
  661 NGKSVIVDLS ADYRFEPSWQ YGLPELNDRE ALRNSKRISN PGCYATGSQV GLTPILSLID 720
  721 GQPSIFGVSG YSGAGTKPSP KNDLNVLTNN LIPYSLTDHI HEREISYRLK QPVAFIPHVA 780
  781 QWFQGITLTI NVPLKKSITS RELRNLYQDR YNGEPLIHVQ GDVPLVKDNA HKHHVSVGGF 840
  841 GVHSSGKRAV IVVTIDNLLK GAATQALQNL NLSCGYDEYA GIHLD

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..352]	PSI-BLAST	73.221849	Acetylglutamate kinase from Thermotoga maritima complexed with its inhibitor arginine
2	View Details	[353..498]	PSI-BLAST	14.522879	No description for 2re1A was found.
3	View Details	[499..566]	FFAS03	1.99	Crystal structure of putative N-acetyl-gamma-glutamyl-phosphate reductase (AK071544) from rice (Oryza sativa)
4	View Details	[567..885]	PSI-BLAST	56.221849	Crystal structure of N-acetyl-gamma-glutamyl-phosphate reductase (TM1782) from Thermotoga maritima at 1.80 A resolution

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
acetylglutamate kinase activity	4.65687695159645	bayes_pls_golite062009
acetyl-CoA:L-glutamate N-acetyltransferase activity	3.26558010592138	bayes_pls_golite062009
catalytic activity	2.83338756483354	bayes_pls_golite062009
kinase activity	2.67408574779231	bayes_pls_golite062009
phosphotransferase activity, carboxyl group as acceptor	2.65970393362911	bayes_pls_golite062009
amino acid kinase activity	2.38310367076654	bayes_pls_golite062009
transferase activity	2.34413838821786	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.29427716951794	bayes_pls_golite062009
glutamate 5-kinase activity	1.96140621254513	bayes_pls_golite062009
aspartate kinase activity	1.88373109708541	bayes_pls_golite062009
N-acetyl-gamma-glutamyl-phosphate reductase activity	1.83646634572281	bayes_pls_golite062009
binding	1.18123995031694	bayes_pls_golite062009
N-acetyltransferase activity	1.13696391910867	bayes_pls_golite062009
N-acyltransferase activity	0.92493110194105	bayes_pls_golite062009
glutamate N-acetyltransferase activity	0.39836407748845	bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity	0.201897604299108	bayes_pls_golite062009
protein binding	0.178881469836152	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.0737389599384877	bayes_pls_golite062009

2

No functions predicted.

3

No functions predicted.

4

Term	Confidence	Notes
oxidoreductase activity	4.00402564572912	bayes_pls_golite062009
N-acetyl-gamma-glutamyl-phosphate reductase activity	3.56815683796128	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.69693546344908	bayes_pls_golite062009
catalytic activity	2.54843319568228	bayes_pls_golite062009
glutamate dehydrogenase [NAD(P)+] activity	2.15778057341677	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	2.00319512154556	bayes_pls_golite062009
transcription regulator activity	1.71554018493443	bayes_pls_golite062009
DNA binding	1.3548434757156	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.11682034462164	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.03017667696669	bayes_pls_golite062009
nucleic acid binding	1.00139988420709	bayes_pls_golite062009
binding	0.791812853115142	bayes_pls_golite062009
transcription factor activity	0.651793924680484	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	0.610013758225609	bayes_pls_golite062009
methylenetetrahydrofolate dehydrogenase activity	0.169301675015808	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	0.162625185692811	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.0992243118937675	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	0.0557896176220603	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.94

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle