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Protein Overview: Hs3st-B-PA, FBpp...

General Information:
Name(s) found: FBpp0304800 [FlyBase]
Hs3st-B-PA / FBpp0074447 [FlyBase]
Description(s) found:
Found 28 descriptions.
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  • type=protein; loc=X:join(19143174..19143356,19143772..19144235,19144787..19145294); ID=FBpp0304800; name=Hs3st-B-PB; parent=FBgn0031005,FBtr0332533; dbxref=FlyBase:FBpp0304800,FlyBase_Annotation_IDs:CG7890-PB,REFSEQ:NP_001259702,GB_protein:AGB95542; MD5=b29c5650981acb399adc9d2f60f2ecc2; length=384; release=r5.56; species=Dmel; [FlyBase]
  • The gene Heparan sulfate 3-O sulfotransferase-B is referred to in FlyBase by the symbol Dmel\Hs3st-B (CG7890, FBgn0031005). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:19143108..19146079. It has the cytological map location 18B5-18B6. There is experimental evidence that it has the molecular function</span>: [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: anatomical structure development; organ morphogenesis; organ development; organelle organization; sensory organ development; regulation of biological process; regulation of anatomical structure size; endosome organization; regulation of neurogenesis; leg morphogenesis; regulation of developmental process; imaginal disc-derived wing margin morphogenesis; lysosome organization; regulation of endosome size; Notch signaling pathway. 3 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: adult segment; adult mesothoracic segment; peripheral nervous system; external compound sense organ; organ system; nervous system; cytoplasmic part; intracellular membrane-bounded organelle; thoracic segment; compound cell cluster organ. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 384 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: imaginal disc-derived leg joint morphogenesis [IMP]
    lysosome organization [IMP]
    endosome organization [IMP]
    imaginal disc-derived wing morphogenesis [IMP]
    imaginal disc-derived wing margin morphogenesis [IMP]
    imaginal disc-derived wing vein specification [IMP]
    imaginal disc-derived wing vein morphogenesis [IMP]
    bristle morphogenesis [IMP]
    regulation of endosome size [IMP]
    Notch signaling pathway [IGI][IMP]
    compound eye morphogenesis [IMP]
    wing disc dorsal/ventral pattern formation [IMP]
    negative regulation of neurogenesis [IMP]
    Molecular Function: [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRDTAATSAQ PAMIVMSIWC SSLSLSSRSL AIALVICVTL VYFSYSFNAC LLASISRSLQ  60
   61 QSNLRNLLAL TSSPRNETNN AANSSSSNSS SSRNSSSTTG APPAQTVTSS LDGAPKYQLL 120
  121 RQQGLRPSRH LPDTLIIGVK KSGTRALLEF IRLHPDVRAA GSEVHFFDRH YQRGLRWYRH 180
  181 HMPYTIEGQI TMEKTPSYFV TKEVPQRVYH MNPATKLLIV VRDPVTRAIS DYTQAASKKA 240
  241 DMKLFEQLAF VNGSYSVVDT NWGPVKIGVY ARYLERWLLY FPLSQLLFIS GERLIMDPAY 300
  301 EIGRVQDFLG LKRVVTEKHF YFNATKGFPC LFKSEARSTP HCLGKTKGRN HPHIDPGAIE 360
  361 RLREFYRPFN NKFYQLTGIN FAWP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..112] MSA 1.28999 View MSA. No confident structure predictions are available.
    2 View Details [113..384] PSI-BLAST 61.39794 Crystal Structure of human 3-O-Sulfotransferase-3 with bound PAP and tetrasaccharide substrate

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.21604035604783 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.88448565327812 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.81213329141196 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.79256074410868 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.7898097319166 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.26314334516725 bayes_pls_golite062009
  • receptor activity
    		•  1.20313362488821 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.13474466330485 bayes_pls_golite062009
  • signal transducer activity
    		•  1.13474466330485 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.682467561649336 bayes_pls_golite062009
  • motor activity
    		•  0.50661339105747 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.442941451960958 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.440672169804309 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.440612929099368 bayes_pls_golite062009
  • nucleotide binding
    		•  0.433111366205869 bayes_pls_golite062009
  • [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
    		•  0.22259207218243 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.194779852865789 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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