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Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate, with a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S. Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
Acc: GO:0008467
Aspect: Molecular Function
Desc: Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate, with a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S.
Synonyms:
  • 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase
  • heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity
  • 3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity
  • 3-OST-1 activity
  • heparin-glucosamine 3-O-sulfotransferase activity
  • glucosaminyl 3-O-sulfotransferase activity
  • isoform/isozyme 1 (3-OST-1, HS3ST1)
  • heparin-glucosamine 3-O-sulphotransferase activity
Proteins in PDR annotated with:
   This term: 8 [Search]
   Term or descendants: 8 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0008467 - [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity (interactive image map)
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