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Protein Overview: l(1)G0007-PA

General Information:
Name(s) found: l(1)G0007-PA / FBpp0073717 [FlyBase]
Description(s) found:
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  • gi|22832718|gb|AAF48351.2| lethal (1) G0007, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|18859729|ref|NP_572947.1| lethal (1) G0007, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|16184298|gb|AAL13782.1| LD24737p [Drosophila melanogaster] [NCBI NR]
  • The gene lethal (1) G0007 is referred to in FlyBase by the symbol Dmel\l(1)G0007 (CG32604, FBgn0026713). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:14095405..14118761. It has the cytological map location 12E3-12E5. Based on sequence similarity, it is predicted to have molecular function</span>: ATP-dependent helicase activity; ATP-dependent RNA helicase activity. There is experimental evidence that it is involved in the biological process</span>: inter-male aggressive behavior; regulation of alternative nuclear mRNA splicing, via spliceosome. 52 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; intersegmental nerve. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG32604-PA translation from_gene[CG32604 CG32604 FBgn0052604] seq_release:3 mol_weight=139582 cds_boundaries:(X:13,932,122..13,955,278[+]) aa_length:1222 transcript_info:[CG32604-RA seq_release:3] gene_info:[gene symbol:CG32604 synonyms:[CG1405 CG1375 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VY54) CG32604 protein (LD24737p) [DrosMelano7227.FASTAC.txt]
  • CG32604-PA, isoform A [Drosophila melanogaster]gi|16184298|gb|AAL13782.1| LD24737p [Drosophila melanogaster]gi|18859729|ref|NP_572947.1| CG32604-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:join(14095496..14097317,14097474..14097667,14116940..14117994,14118058..14118655); ID=FBpp0073717; name=l(1)G0007-PA; parent=FBgn0026713,FBtr0073900; dbxref=GB_protein:AAF48351.2,FlyBase:FBpp0073717,FlyBase_Annotation_IDs:CG32604-PA,RE [fly-100309-contam.fasta]
  • CG32604-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • LD24737p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • lethal (1) G0007 CG32604-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:join(14095496..14097317,14097474..14097667,14116940..14117994,14118058..14118655); ID=FBpp0073717; name=l(1)G0007-PA; parent=FBgn0026713,FBtr0073900; dbxref=GB_protein:AAF48351.2,FlyBase:FBpp0073717,FlyBase_Annotation_IDs:CG32604-PA,REFSEQ:NP_572947,GB_protein:AAF48351; MD5=ae7dd7f1c5ccef418068f8f5c32cbc95; length=1222; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:join(14095496..14097317,14097474..14097667,14116940..14117994,14118058..14118655); ID=FBpp0073717; name=l(1)G0007-PA; parent=FBgn0026713,FBtr0073900; dbxref=GB_protein:AAF48351.2,FlyBase:FBpp0073717,FlyBase_Annotation_IDs:CG32604-PA,REFSEQ:NP_572947,GB_protein:AAF48351; MD5=ae7dd7f1c5ccef418068f8f5c32cbc95; length=1222; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • LD24737p OS=Drosophila melanogaster GN=l(1)G0007 PE=2 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:join(14095496..14097317,14097474..14097667,14116940..14117994,14118058..14118655); ID=FBpp0073717; name=l(1)G0007-PA; parent=FBgn0026713,FBtr0073900; dbxref=GB_protein:AAF48351.2,FlyBase:FBpp0073717,FlyBase_Annotation_IDs:CG32604-PA,REFSEQ:NP_572947,GB_protein:AAF48351,FlyMine:FBpp0073717,modMine:FBpp0073717; MD5=ae7dd7f1c5ccef418068f8f5c32cbc95; length=1222; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:join(14201463..14203284,14203441..14203634,14222907..14223961,14224025..14224622); ID=FBpp0073717; name=l(1)G0007-PA; parent=FBgn0026713,FBtr0073900; dbxref=GB_protein:AAF48351.2,FlyBase:FBpp0073717,FlyBase_Annotation_IDs:CG32604-PA,REFSEQ:NP_572947,GB_protein:AAF48351,FlyMine:FBpp0073717,modMine:FBpp0073717; MD5=ae7dd7f1c5ccef418068f8f5c32cbc95; length=1222; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:join(14201463..14203284,14203441..14203634,14222907..14223961,14224025..14224622); ID=FBpp0073717; name=l(1)G0007-PA; parent=FBgn0026713,FBtr0073900; dbxref=GB_protein:AAF48351.2,FlyBase:FBpp0073717,FlyBase_Annotation_IDs:CG32604-PA,REFSEQ:NP_572947,GB_protein:AAF48351,FlyMine:FBpp0073717,modMine:FBpp0073717; MD5=ae7dd7f1c5ccef418068f8f5c32cbc95; length=1222; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • LD24737p OS=Drosophila melanogaster GN=l(1)G0007 PE=1 SV=2 [DROME.fasta.20160308]
  • FBpp0073717 type=protein; loc=X:join(14201463..14203284,14203441..14203634,14222907..14223961,14224025..14224622); ID=FBpp0073717; name=l(1)G0007-PA; parent=FBgn0026713,FBtr0073900; dbxref=GB_protein:AAF48351.2,FlyBase:FBpp0073717,FlyBase_Annotation_IDs:CG32604-PA,REFSEQ:NP_572947,GB_protein:AAF48351,FlyMine:FBpp0073717,modMine:FBpp0073717; MD5=ae7dd7f1c5ccef418068f8f5c32cbc95; length=1222; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:join(14201463..14203284,14203441..14203634,14222907..14223961,14224025..14224622); ID=FBpp0073717; name=l(1)G0007-PA; parent=FBgn0026713,FBtr0073900; dbxref=GB_protein:AAF48351.2,FlyBase:FBpp0073717,FlyBase_Annotation_IDs:CG32604-PA,REFSEQ:NP_572947,GB_protein:AAF48351,UniProt/TrEMBL:Q9VY54,FlyMine:FBpp0073717,modMine:FBpp0073717; MD5=ae7dd7f1c5ccef418068f8f5c32cbc95; length=1222; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1222 amino acids

    Gene Ontology:
    Cellular Component: spliceosomal complex [ISS]
    Biological Process: regulation of alternative nuclear mRNA splicing, via spliceosome [IMP]
    inter-male aggressive behavior [IMP]
    nuclear mRNA splicing, via spliceosome [ISS]
    Molecular Function: nucleic acid binding [IEA]
    ATP binding [IEA]
    ATP-dependent helicase activity [ISS]
    ATP-dependent RNA helicase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDDDESGVH RLEGTAGQET RGGLVIRKPK DAGAGGGGGF KVPQGSMLGL DKLAAKRRAE  60
   61 KERSERLISF KDSEFDDTGG GSSTPQANAS GASSEFAFKK PDTKSFEKLR GQLREHKDDT 120
  121 PSHTGGVSEK ARERLREHIQ RDRKRGPVSS TAAEGRDRDR DWDRDRRRDR DRDRDRDRDR 180
  181 RQHRERERDR HRSWDRDRGR DRDRDRSMSE RSVHTPREPG TPGGSSGGIS NSSWDDEDGE 240
  241 FGQRKSDWDM PTPRRHGNKS GDWSVRSGGS RRNHGRQDDT VRPTPAHRYN QWAHGRKRSG 300
  301 ATPWGEDPES LDLWEEEQRR LDREWYNIDE GYDDENNPFG GPNSEYFRKR EEQLEQKRTK 360
  361 RISAQQRQNN RDNELWERNR MLTSGVVTLI SVNDDFDEEA LERVHLLVHH IIPPFLDGRI 420
  421 VFTKQPEPVV PVKDPTSDMA LLARKGSALV RNYREQKERR KAQKKHWELS GTKLGNIMGV 480
  481 QRPQDEDDMR FDKEKDKADY RKDQKFADHM RDQDTGGKSD FSRKKTISEQ RRFLPVFASR 540
  541 QELLNVIREN SVIIIVGETG SGKTTQLTQY LHEDGYSKRG MIGCTQPRRV AAMSVAKRVS 600
  601 DEMDTQLGED VGYAIRFEDC TSERTVIKYM TDGILLRESL RDPELDSYSA IIMDEAHERS 660
  661 LSTDVLFGLL REIVARRHDL KLIVTSATMD SSKFATFFGN VPTFTIPGRT FPVDVMFSKN 720
  721 TCEDYVESAV KQALQVHLTP NEGDMLIFMP GQEDIEVTCE VLEERLAEID NAPALSILPI 780
  781 YSQLPSDLQA KIFQKSSDGL RKCVVATNIA ETSLTVDGII YVIDSGYCKL KVYNPRIGMD 840
  841 ALQIYPISQA NANQRSGRAG RTGPGQAYRL YTQRQYKDEL LALTVPEIQR TNLANTVLLL 900
  901 KSLGVVDLLQ FHFMDPPPQD NILNSLYQLW ILGALDHTGA LTTLGRQMAE FPLDPPQCQM 960
  961 LIVACRMGCS AEVLIIVSML SVPSIFYRPK GREDEADGVR EKFQRPESDH LTYLNVYQQW1020
 1021 RQNNYSSTWC NEHFIHIKAM RKVREVRQQL KDIMTQQNLS VISCGIDWDI VRKCICSAYF1080
 1081 YQAARLKGIG EYVNLRTGMP CHLHPTSALY GLGTTPDYVV YHELIMTAKE YMQCATAVDG1140
 1141 YWLAELGPMF FSVKESGRSG REKKKQAAEH LKEMEEQMLK AQHEMEERKQ QAAEREEQLA1200
 1201 TKQEIATPGN ATPRRTPARI GL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..203] MSA 5.146994 View MSA. No confident structure predictions are available.
    2 View Details [204..392] deduced N/A No confident structure predictions are available.
    3 View Details [393..515] PSI-BLAST 66.045757 No description for 2db3A was found.
    4 View Details [516..1090] PSI-BLAST 26.09691 No description for 2p6rA was found.
    5 View Details [1091..1222] MSA 1.596995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
    		• 4.704140727858 bayes_pls_golite062009
  • binding
    		•  2.44689197844883 bayes_pls_golite062009
  • RNA binding
    		•  2.29590582680214 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.57653963868443 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.42791449104435 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.41477043612798 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.39335733374328 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.36724390116598 bayes_pls_golite062009
  • DNA binding
    		•  1.11699929651302 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.989226939888218 bayes_pls_golite062009
  • mRNA binding
    		•  0.76699944561918 bayes_pls_golite062009
  • helicase activity
    		•  0.6191010101321 bayes_pls_golite062009
  • motor activity
    		•  0.61636596887462 bayes_pls_golite062009
  • structural molecule activity
    		•  0.596382945962261 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.461763181659193 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.458831409927227 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.455976987338331 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.422944846459286 bayes_pls_golite062009
  • snRNA binding
    		•  0.418985924846052 bayes_pls_golite062009
  • DNA insertion or deletion binding
    		•  0.36048959456844 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.338958888186454 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • translation release factor activity
    		•  0.178286731022211 bayes_pls_golite062009
  • translation termination factor activity
    		•  0.151456842619444 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • protein binding
    		•  0.071010918255742 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0434163635422169 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.0272673919333979 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle