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Protein Overview: Clic-PA, FBpp0311923

General Information:
Name(s) found: FBpp0311923 [FlyBase]
Clic-PA / FBpp0073666 [FlyBase]
Description(s) found:
Found 28 descriptions.
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  • type=protein; loc=X:complement(13707761..13707838,13707908..13708018,13708410..13708919,13715958..13716041); ID=FBpp0311923; name=Clic-PC; parent=FBgn0030529,FBtr0346089; dbxref=FlyBase:FBpp0311923,FlyBase_Annotation_IDs:CG10997-PC; MD5=fb8a686fb8e93226e77da9f2e89cd5f1; length=260; release=r5.56; species=Dmel; [FlyBase]
  • The gene Chloride intracellular channel is referred to in FlyBase by the symbol Dmel\Clic (CG10997, FBgn0030529). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:13707475..13716357. It has the cytological map location 12C5-12C6. There is experimental evidence that it has the molecular function</span>: calcium ion binding; chloride channel activity; lipid binding. There is experimental evidence that it is involved in the biological process</span>: determination of adult lifespan; response to oxidative stress. 19 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 260 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: response to oxidative stress [IMP]
    determination of adult lifespan [IMP]
    Molecular Function: calcium ion binding [IDA]
    lipid binding [IDA]
    chloride channel activity [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEVESQQSQ ETNGSSKFDV PEIELIIKAS TIDGRRKGAC LFCQEYFMDL YLLAELKTIS  60
   61 LKVTTVDMQK PPPDFRTNFE ATHPPILIDN GLAILENEKI ERHIMKNIPG GYNLFVQDKE 120
  121 VATLIENLYV KLKLMLVKKD EAKNNALLSH LRKINDHLSA RNTRFLTGDT MCCFDCELMP 180
  181 RLQHIRVAGK YFVDFEIPTH LTALWRYMYH MYQLDAFTQS CPADQDIINH YKLQQSLKMK 240
  241 KHEELETPTF TTYIPIDISE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..260] PSI-BLAST 32.69897 Crystal Structure of a Soluble Dimeric Form of Oxidised CLIC1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • antioxidant activity
    		•  3.8464796631544 bayes_pls_golite062009
  • peroxidase activity
    		•  3.44705858438242 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  3.44705858438242 bayes_pls_golite062009
  • chloride channel activity
    		•  3.43309717940669 bayes_pls_golite062009
  • anion channel activity
    		•  3.43309717940669 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  2.95357085969061 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.80355375991545 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.57358006453916 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  2.23310780102446 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  2.12777217096121 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  2.012364779649 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  1.96134566495756 bayes_pls_golite062009
  • ion channel activity
    		•  1.93467867578363 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.85548385190106 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.85004112385169 bayes_pls_golite062009
  • channel activity
    		•  1.85004112385169 bayes_pls_golite062009
  • voltage-gated chloride channel activity
    		•  1.53793640572798 bayes_pls_golite062009
  • voltage-gated anion channel activity
    		•  1.53793640572798 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.48840493532061 bayes_pls_golite062009
  • signal transducer activity
    		•  1.48840493532061 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.32811008894503 bayes_pls_golite062009
  • transporter activity
    		•  1.27462890839069 bayes_pls_golite062009
  • binding
    		•  1.25802922431343 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07599729927609 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, transposing S-S bonds
    		•  1.04609283259723 bayes_pls_golite062009
  • protein disulfide isomerase activity
    		•  1.04609283259723 bayes_pls_golite062009
  • gated channel activity
    		•  1.02378767677496 bayes_pls_golite062009
  • selenium binding
    		•  1.02136183687858 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, interconverting keto- and enol-groups
    		•  0.959318279607901 bayes_pls_golite062009
  • phospholipid-hydroperoxide glutathione peroxidase activity
    		•  0.874146425427531 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.861215137904704 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.677675994999412 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.661169709002081 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.52671047749426 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.32476916216195 bayes_pls_golite062009
  • DNA binding
    		•  0.278017923256183 bayes_pls_golite062009
  • protein binding
    		•  0.134341907247724 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.0801269279614203 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  0.0719543694089202 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.00678211696545472 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle