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Protein Overview: PH4alphaNE3-PA

General Information:
Name(s) found: PH4alphaNE3-PA / FBpp0085029 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene prolyl-4-hydroxylase-alpha NE3 is referred to in FlyBase by the symbol Dmel\PH4Ã?&#142;Ã?±NE3 (CG31017, FBgn0051017). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:26429903..26431866. It has the cytological map location 100A1. Based on sequence similarity, it is predicted to have molecular function</span>: procollagen-proline 4-dioxygenase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: oxidation reduction. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 481 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IEA]
    procollagen-proline 4-dioxygenase complex [IC]
    Biological Process: oxidation reduction [IEA]
    Molecular Function: procollagen-proline 4-dioxygenase activity [ISS]
    L-ascorbic acid binding [IEA]
    oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [IEA]
    iron ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFCKVESTLN WESRQEFLDT ESAKMDLMQL DVELIDNLMN YAEKIDEKAS QLKRLAQELR  60
   61 QPLHSAKGRE EEYLGNPLHS FPLIRHMYQD WRYLEEFMKK PVGEEEIQFL RRKLPELPWQ 120
  121 VDTEEASVSI FRIAETYGMM PWDMANGLID NVRFNSTLPA LDCFEVAKMY FKWGYFKQAL 180
  181 QWITISKARM KEEYSGVYEV LGMNRQDVAL LQARCLVELD RRDEAHEVLL DQPDLADNSI 240
  241 SLLDQFKANP YEAIDSSPKL GEGYKRLCRS SFSPNPSKLH CRYNSTTSAF LILAPLKMEE 300
  301 ISLEPHIVVY HDILPDKDIQ QLITLAEPLL KPTEMFDDNK NEARSSYRTP LGGPLLDSLT 360
  361 QRMRDITGLQ IRQGNPINII KYGFGAPYTN YYDFFKKRNS ESKGFGDRMA TFMFYLNDAP 420
  421 YGGATVFPRL NVKVPAERGK VLFWYNLNGD THDMEPTTMH AACPVFHGSK WVMTAWIHEY 480
  481 D

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..153] Pfam 59.080922 No description for PF08336.2 was found. No confident structure predictions are available.
    2 View Details [154..252] PSI-BLAST 13.221849 Crystal structure of peptide-substrate-binding domain of human type I collagen prolyl 4-hydroxylase
    3 View Details [253..481] FFAS03 4.95 No description for 2hbtA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • procollagen-proline 4-dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • procollagen-proline dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • peptidyl-proline dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • peptidyl-proline 4-dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
    		•  5.01373106146099 bayes_pls_golite062009
  • binding
    		•  2.09193012129784 bayes_pls_golite062009
  • protein binding
    		•  1.52807685989528 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor
    		•  0.534990536504941 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle