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Protein Overview: noi-PA

General Information:
Name(s) found: noi-PA / FBpp0078400 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene noisette is referred to in FlyBase by the symbol Dmel\noi (CG2925, FBgn0014366). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:1415323..1417180. It has the cytological map location 83B4. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: zinc ion binding; nucleic acid binding. There is experimental evidence that it is involved in the biological process</span>: fertilization; positive regulation of NFAT protein import into nucleus; mitotic spindle organization. 15 alleles are reported. The phenotypes of these alleles are annotated with: egg; medial triple row; sex comb; oocyte nucleus; dorsal appendage; nurse cell. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 503 amino acids

    Gene Ontology:
    Cellular Component: catalytic step 2 spliceosome [IDA]
    precatalytic spliceosome [IDA]
    spliceosomal complex [ISS]
    U2 snRNP [ISS]
    Biological Process: positive regulation of NFAT protein import into nucleus [IMP]
    mitotic spindle organization [IMP]
    fertilization [IMP]
    nuclear mRNA splicing, via spliceosome [IC][ISS]
    Molecular Function: nucleic acid binding [IEA]
    zinc ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METLLEQQRR LHEERERLVK LMVDEHATKK PGEKERIHSE HRLKYLMELH HNSTSQLRDL  60
   61 YEDKDNERKA EIAALSGPNE FNEFYARLKQ IKQFYKSHPA EVSVPLSVEF DEMIRVYNNP 120
  121 DDMSALVEFT DEEGGGRYLD LNECYELYLN LRSVEKLDYI TYLMSFDHVF DIPRERKNRE 180
  181 YRIYIETLND YLHHFILRIQ PLLDLEGELL KVELDFQRQW LMGTFPGFSI KETESALANT 240
  241 GAHLDLSAFS SWEELASLGL DRLKSALVAL GLKCGGTLEE RAQRLFSTKG KSTLDPALMA 300
  301 KKPSAKTASA QSREHERHKE IAQLEALLYK YADLLSEQRA ATKENVQRKQ ARTGGERDDS 360
  361 DVEASESDNE DDPDADDVPY NPKNLPLGWD GKPIPYWLYK LHGLNISYNC EICGNFTYKG 420
  421 PKAFQRHFAE WRHAHGMRCL GIPNTAHFAN VTQIEDAITL WEKLKSQKQS ERWVADQEEE 480
  481 FEDSLGNVVN RKTFEDLKRQ GLL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..231] MSA 1.039947 View MSA. No confident structure predictions are available.
    2 View Details [232..306] MSA 7.051996 View MSA. No confident structure predictions are available.
    3 View Details [307..372] deduced N/A No confident structure predictions are available.
    4 View Details [373..503] FFAS03 1.05 Solution Structure of a Human C2H2-type Zinc Finger Protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • transcription regulator activity
    		•  3.37529385176635 bayes_pls_golite062009
  • DNA binding
    		•  3.3049326844117 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.24981360535232 bayes_pls_golite062009
  • snRNA binding
    		•  3.16782731106334 bayes_pls_golite062009
  • RNA binding
    		•  3.11293528368816 bayes_pls_golite062009
  • binding
    		•  2.99742524370422 bayes_pls_golite062009
  • U1 snRNA binding
    		•  2.86343975521155 bayes_pls_golite062009
  • transcription factor activity
    		•  2.44389510173662 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.57041104288348 bayes_pls_golite062009
  • mRNA binding
    		•  1.28525296322454 bayes_pls_golite062009
  • transcription activator activity
    		•  1.20323819132961 bayes_pls_golite062009
  • protein binding
    		•  0.952480850696098 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.732558534458316 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.686318575498149 bayes_pls_golite062009
  • chromatin binding
    		•  0.626365497850853 bayes_pls_golite062009
  • transcription factor binding
    		•  0.515821187939278 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.380243728411498 bayes_pls_golite062009
  • catalytic activity
    		•  0.263007611601737 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.200483461579207 bayes_pls_golite062009
  • tubulin binding
    		•  0.151955152284472 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.113925660147477 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0855506955761403 bayes_pls_golite062009
  • microtubule binding
    		•  0.05082413668213 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle