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View Structure Prediction Details

Protein: noi-PA
Organism: Drosophila melanogaster
Length: 503 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for noi-PA.

Description E-value Query
Range
Subject
Range
gi|54311245, gi|... - gi|54311245|gb|AAH84823.1| LOC495359 protein [Xenopus laevis], gi|148227146|ref|NP_001088491.1| hypo...
701.0 [0..1] [503..1]

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Predicted Domain #1
Region A:
Residues: [1-231]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METLLEQQRR LHEERERLVK LMVDEHATKK PGEKERIHSE HRLKYLMELH HNSTSQLRDL  60
   61 YEDKDNERKA EIAALSGPNE FNEFYARLKQ IKQFYKSHPA EVSVPLSVEF DEMIRVYNNP 120
  121 DDMSALVEFT DEEGGGRYLD LNECYELYLN LRSVEKLDYI TYLMSFDHVF DIPRERKNRE 180
  181 YRIYIETLND YLHHFILRIQ PLLDLEGELL KVELDFQRQW LMGTFPGFSI K

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [232-306]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETESALANTG AHLDLSAFSS WEELASLGLD RLKSALVALG LKCGGTLEER AQRLFSTKGK  60
   61 STLDPALMAK KPSAK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [307-372]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TASAQSREHE RHKEIAQLEA LLYKYADLLS EQRAATKENV QRKQARTGGE RDDSDVEASE  60
   61 SDNEDD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [373-503]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDADDVPYNP KNLPLGWDGK PIPYWLYKLH GLNISYNCEI CGNFTYKGPK AFQRHFAEWR  60
   61 HAHGMRCLGI PNTAHFANVT QIEDAITLWE KLKSQKQSER WVADQEEEFE DSLGNVVNRK 120
  121 TFEDLKRQGL L

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.05
Match: 1zr9A
Description: Solution Structure of a Human C2H2-type Zinc Finger Protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.37529385176635 bayes_pls_golite062009
DNA binding 3.3049326844117 bayes_pls_golite062009
nucleic acid binding 3.24981360535232 bayes_pls_golite062009
snRNA binding 3.16782731106334 bayes_pls_golite062009
RNA binding 3.11293528368816 bayes_pls_golite062009
binding 2.99742524370422 bayes_pls_golite062009
U1 snRNA binding 2.86343975521155 bayes_pls_golite062009
transcription factor activity 2.44389510173662 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.57041104288348 bayes_pls_golite062009
mRNA binding 1.28525296322454 bayes_pls_golite062009
transcription activator activity 1.20323819132961 bayes_pls_golite062009
protein binding 0.952480850696098 bayes_pls_golite062009
sequence-specific DNA binding 0.732558534458316 bayes_pls_golite062009
transcription repressor activity 0.686318575498149 bayes_pls_golite062009
chromatin binding 0.626365497850853 bayes_pls_golite062009
transcription factor binding 0.515821187939278 bayes_pls_golite062009
cytoskeletal protein binding 0.380243728411498 bayes_pls_golite062009
catalytic activity 0.263007611601737 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.200483461579207 bayes_pls_golite062009
tubulin binding 0.151955152284472 bayes_pls_golite062009
transcription cofactor activity 0.113925660147477 bayes_pls_golite062009
structure-specific DNA binding 0.0855506955761403 bayes_pls_golite062009
microtubule binding 0.05082413668213 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle