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Protein Overview: eIF2B-delta-PA

General Information:
Name(s) found: eIF2B-delta-PA / FBpp0071923 [FlyBase]
Description(s) found:
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  • gi|7291571|gb|AAF46995.1| eIF2B-delta, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|19922816|ref|NP_611790.1| eIF2B-delta, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|17862018|gb|AAL39486.1| LD05345p [Drosophila melanogaster] [NCBI NR]
  • The gene eIF2B-Ã?&#142;Ã?´ is referred to in FlyBase by the symbol Dmel\eIF2B-Ã?&#142;Ã?´ (CG10315, FBgn0034858). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:19274016..19276575. It has the cytological map location 59D9-59D10. Based on sequence similarity, it is predicted to have molecular function</span>: translation initiation factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: translational initiation. 4 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • >CG10315-PA translation from_gene[CG10315 eIF2B-delta FBgn0034858] seq_release:3 mol_weight=67612 cds_boundaries:(2R:18,430,366..18,432,537[+]) aa_length:626 transcript_info:[CG10315-RA seq_release:3] gene_info:[gene symbol:eIF2B-delta FBgn0034858 gene [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9W1Q8) CG10315 protein (LD05345p) [DrosMelano7227.FASTAC.txt]
  • (AE003460) CG10315 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG10315-PA, isoform A [Drosophila melanogaster]gi|17862018|gb|AAL39486.1| LD05345p [Drosophila melanogaster]gi|19922816|ref|NP_611790.1| CG10315-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:join(19274321..19274350,19274530..19275135,19275195..19275755,19275812..19276495); ID=FBpp0071923; name=eIF2B-delta-PA; parent=FBgn0034858,FBtr0072014; dbxref=FlyBase:FBpp0071923,FlyBase_Annotation_IDs:CG10315-PA,GB_protein:AAF46995.1 [fly-100309-contam.fasta]
  • eIF2B-delta CG10315-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG10315-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • LD05345p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:join(19274321..19274350,19274530..19275135,19275195..19275755,19275812..19276495); ID=FBpp0071923; name=eIF2B-delta-PA; parent=FBgn0034858,FBtr0072014; dbxref=FlyBase:FBpp0071923,FlyBase_Annotation_IDs:CG10315-PA,GB_protein:AAF46995.1,REFSEQ:NP_611790,GB_protein:AAF46995; MD5=7bed57943757acd542d389f381596508; length=626; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:join(19274321..19274350,19274530..19275135,19275195..19275755,19275812..19276495); ID=FBpp0071923; name=eIF2B-delta-PA; parent=FBgn0034858,FBtr0072014; dbxref=FlyBase:FBpp0071923,FlyBase_Annotation_IDs:CG10315-PA,GB_protein:AAF46995.1,REFSEQ:NP_611790,GB_protein:AAF46995; MD5=7bed57943757acd542d389f381596508; length=626; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • LD05345p OS=Drosophila melanogaster GN=eIF2B-delta PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:join(19274321..19274350,19274530..19275135,19275195..19275755,19275812..19276495); ID=FBpp0071923; name=eIF2B-delta-PA; parent=FBgn0034858,FBtr0072014; dbxref=FlyBase:FBpp0071923,FlyBase_Annotation_IDs:CG10315-PA,GB_protein:AAF46995.1,REFSEQ:NP_611790,GB_protein:AAF46995,FlyMine:FBpp0071923,modMine:FBpp0071923; MD5=7bed57943757acd542d389f381596508; length=626; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • LD05345p OS=Drosophila melanogaster GN=eIF2B-delta PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=2R:join(23386798..23386827,23387007..23387612,23387672..23388232,23388289..23388972); ID=FBpp0071923; name=eIF2B-delta-PA; parent=FBgn0034858,FBtr0072014; dbxref=FlyBase:FBpp0071923,FlyBase_Annotation_IDs:CG10315-PA,GB_protein:AAF46995.1,REFSEQ:NP_611790,GB_protein:AAF46995,FlyMine:FBpp0071923,modMine:FBpp0071923; MD5=7bed57943757acd542d389f381596508; length=626; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:join(23386798..23386827,23387007..23387612,23387672..23388232,23388289..23388972); ID=FBpp0071923; name=eIF2B-delta-PA; parent=FBgn0034858,FBtr0072014; dbxref=FlyBase:FBpp0071923,FlyBase_Annotation_IDs:CG10315-PA,GB_protein:AAF46995.1,REFSEQ:NP_611790,GB_protein:AAF46995,FlyMine:FBpp0071923,modMine:FBpp0071923; MD5=7bed57943757acd542d389f381596508; length=626; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0071923 type=protein; loc=2R:join(23386798..23386827,23387007..23387612,23387672..23388232,23388289..23388972); ID=FBpp0071923; name=eIF2B-delta-PA; parent=FBgn0034858,FBtr0072014; dbxref=FlyBase:FBpp0071923,FlyBase_Annotation_IDs:CG10315-PA,GB_protein:AAF46995.1,REFSEQ:NP_611790,GB_protein:AAF46995,FlyMine:FBpp0071923,modMine:FBpp0071923; MD5=7bed57943757acd542d389f381596508; length=626; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:join(23386798..23386827,23387007..23387612,23387672..23388232,23388289..23388972); ID=FBpp0071923; name=eIF2Bdelta-PA; parent=FBgn0034858,FBtr0072014; dbxref=FlyBase:FBpp0071923,FlyBase_Annotation_IDs:CG10315-PA,GB_protein:AAF46995.1,REFSEQ:NP_611790,GB_protein:AAF46995,UniProt/TrEMBL:Q9W1Q8,FlyMine:FBpp0071923,modMine:FBpp0071923; MD5=7bed57943757acd542d389f381596508; length=626; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 626 amino acids

    Gene Ontology:
    Cellular Component: cytosol [ISS][NAS]
    eukaryotic translation initiation factor 2B complex [ISS]
    Biological Process: translational initiation [ISS]
    Molecular Function: translation initiation factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLTSEQVPQ TLKSKHKKQR QRNRPRNKRN RLEDSHSTTQ ETSAIDATSA MPGNAVDPLA  60
   61 TEKTRDQIMA EREAKKLAKQ AKKQKTAPTP TAATPAVLTT PSAPATKIIT EVEQTTITTK 120
  121 LTTTTTTKVQ DAVASKTTQP AAVNGKDAEA GEKTREQIKA EREAKKAAKK AGKGGGAKVE 180
  181 GIAQQLADLK VAEKAPVAAS AAPSTTEADQ EKKKPALSKA ERRAIQEAQR AAKAQVQTKK 240
  241 AQHAAKAPPS AAPKGPNRKS VSPTTAATSS SPVKCPASTP NVDCRVKLFN HLVCAKEDSQ 300
  301 FINDPLVHPS IARLGVQYAK RTVVGSNARC IAFLHALRQV VHDFETPAKK EFGRSLDAAV 360
  361 KHHVDHLHKC RPLAVSVSNA YKQFKNQLTQ LPADVPETES KELLVHFIDT YIENQIGKAA 420
  421 QAISGFLQEK ITDGDVLLTF ACSSLIQFIC EEAKRRQVAF RVIVVDSRPG CEGQELLRRL 480
  481 HATGIPCTYV LINAVGYVMA EATKVLLGAH ALLANGYVMA RTGTAQVALV ANAHNVPVLV 540
  541 CCETHKFSER FQTDAIVYNE LSDPNQLVRG DKCQLSNWAA KGKLLPLNLS YDITPPELVS 600
  601 AVVTEVAILP CTSVPVILRI KPDIGY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..111] deduced N/A No confident structure predictions are available.
    2 View Details [112..285] FFAS03 1.16 No description for 2j63A was found.
    3 View Details [286..626] PSI-BLAST 93.0 X-ray crystal structure of aIF-2B alpha subunit-related translation initiation factor [Thermotoga maritima]

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • translation initiation factor activity
    		•  10.1099993541596 bayes_pls_golite062009
  • translation regulator activity
    		•  5.74669335554405 bayes_pls_golite062009
  • catalytic activity
    		•  1.31732715713197 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  1.09424756417577 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.690575841886046 bayes_pls_golite062009
  • binding
    		•  0.306360407226215 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle