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Protein Overview: grau-PA

General Information:
Name(s) found: grau-PA / FBpp0071477 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene grauzone is referred to in FlyBase by the symbol Dmel\grau (CG33133, FBgn0001133). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:16897271..16899424. It has the cytological map location 57B9. There is experimental evidence that it has the molecular function</span>: specific RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: female meiosis; pole cell formation; cellularization; egg activation. 15 alleles are reported. The phenotype of these alleles is annotated with: pole cell. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 570 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    Biological Process: female meiosis [IMP]
    homologous chromosome segregation [TAS]
    pole cell formation [IMP]
    egg activation [IMP]
    cellularization [IMP]
    regulation of transcription from RNA polymerase II promoter [TAS]
    Molecular Function: zinc ion binding [IEA]
    specific RNA polymerase II transcription factor activity [IMP][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDICRLCLRG VSGAQMCLQI FDVDSGESKV AEVLRQHFWF EVLPNDEISK VICNVCWTQV  60
   61 SEFHQFYVSI QEAQVIYATT SKFKQDPEMV NTSWPEEVLM PADVLAVDND VGAQINVNPL 120
  121 DELDLSQPMS PEDSKVGIKT ERQSPDMELL FEDANNEQDE DYEDDEDDDT DDLIVTRSGR 180
  181 KRKRDVAKPA KTKRGTVSVG RKGKEKMVVK RGPPKRIFKM ERLPPFCKED EELIKRYIVM 240
  241 GCELCIFLAE DFDGIREHFK DKHPDERPYI KCCGRKLNKR CLIQEHARRH ENPEYIKCKD 300
  301 CGKVFANSSV LRAHWLVHHV PDEECDFQCE DCGKRFSRRN LLELHKGSHV PVNERKFICP 360
  361 QCPKHNAFAT EYHMQVHISM QHRKAANICH VCGKKIKDKA VFEKHVRLHF EESGPRIKCP 420
  421 RPDCESWLKD EDNLKQHLRR HNDEGKLFIC SECGKSCKNS RALIGHKRYS HSNVIYTCEQ 480
  481 CGKTFKKDIS LKEHMAQHTG EPLYKCPFCP RTFNSNANMH SHKKKMHPVE WDIWRKTKTG 540
  541 SSQKVLPSAQ VAQMFRDDAD VAAIANDYSG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..89] FFAS03 3.36 Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone
    2 View Details [90..172] deduced N/A No confident structure predictions are available.
    3 View Details [173..339] PSI-BLAST 15.0 Solution structure of tandem repeat of the zf-C2H2 domains of human zinc finger protein 297B
    4 View Details [340..570] PSI-BLAST 57.0 No description for 2i13A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  3.84932768708444 bayes_pls_golite062009
  • DNA binding
    		•  3.45124926204188 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.34875987514951 bayes_pls_golite062009
  • binding
    		•  2.8684204787273 bayes_pls_golite062009
  • transcription factor activity
    		•  2.74592237402384 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.23212813739998 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.83119162033863 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.66264161250652 bayes_pls_golite062009
  • transcription activator activity
    		•  1.45965791386122 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.44741411126911 bayes_pls_golite062009
  • protein binding
    		•  1.30321965120678 bayes_pls_golite062009
  • transcription factor binding
    		•  1.22761682002 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.1269808729848 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.0478696280786 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.02819346233483 bayes_pls_golite062009
  • structural molecule activity
    		•  0.958501322313092 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.449959641856445 bayes_pls_golite062009
  • catalytic activity
    		•  0.133319360419662 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.0220126735489528 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  4.70988788192472 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.58713908116892 bayes_pls_golite062009
  • DNA binding
    		•  4.56219307357342 bayes_pls_golite062009
  • transcription factor activity
    		•  3.50954949535763 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.27542149084008 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22082323675675 bayes_pls_golite062009
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • transcription activator activity
    		•  2.19952417915035 bayes_pls_golite062009
  • chromatin binding
    		•  2.18464662431232 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.63161912031789 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.42975942698743 bayes_pls_golite062009
  • transcription factor binding
    		•  1.39608963544799 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.34049786451995 bayes_pls_golite062009
  • protein binding
    		•  1.00484935878505 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.77874411480713 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.240825841910931 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.0129353639725593 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle