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Protein Overview: rib-PA, FBpp0303090

General Information:
Name(s) found: FBpp0303090 [FlyBase]
rib-PA / FBpp0085700 [FlyBase]
Description(s) found:
Found 31 descriptions.
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  • type=protein; loc=2R:15165634..15167619; ID=FBpp0303090; name=rib-PB; parent=FBgn0003254,FBtr0330057; dbxref=FlyBase:FBpp0303090,FlyBase_Annotation_IDs:CG7230-PB,REFSEQ:NP_001261084,GB_protein:AGB93616; MD5=29c866bfff40feea86ed79e88e3d2f5b; length=661; release=r5.56; species=Dmel; [FlyBase]
  • The gene ribbon is referred to in FlyBase by the symbol Dmel\rib (CG7230, FBgn0003254). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15163231..15168901. It has the cytological map location 56C6. It is reported to have molecular function</span>: DNA binding; transcription factor activity. There is experimental evidence for 11 unique biological process</span> terms, many of which group under: anatomical structure development; organ morphogenesis; organ development; open tracheal system development; gut development; embryonic development via the syncytial blastoderm; embryonic hindgut morphogenesis; regulation of developmental process; gland morphogenesis; embryonic development ending in birth or egg hatching; protein localization. 10 alleles are reported. The phenotypes of these alleles are annotated with 30 unique terms, many of which group under: organ system; peripheral nervous system; nervous system; embryonic/larval tracheal system; embryonic nervous system; cuticle; portion of tissue; abdominal lateral pentascolopidial chordotonal organ lch5; cuticular specialization; integumentary system. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 661 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS][TAS]
    Biological Process: regulation of Malpighian tubule diameter [IMP]
    regulation of cell shape [IMP][TAS]
    dorsal closure [IMP][NAS][TAS]
    cytoskeleton organization [TAS]
    Malpighian tubule morphogenesis [IMP]
    head involution [IMP]
    protein localization [IMP]
    hindgut morphogenesis [IMP]
    salivary gland development [TAS]
    regulation of transcription [TAS]
    salivary gland morphogenesis [IMP][NAS]
    open tracheal system development [IMP][NAS][TAS]
    epithelial cell migration, open tracheal system [IMP]
    central nervous system development [IMP]
    primary branching, open tracheal system [TAS]
    cellular membrane organization [TAS]
    cell migration [TAS]
    lumen formation, open tracheal system [TAS]
    Molecular Function: DNA binding [IEA][NAS]
    transcription factor activity [TAS]
    protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGPTAPVAS SGEVGQTYCL RWNNHQTNLV QILHALHEVG SYVDCSLVVD DEQFQAHRVV  60
   61 LAANSPYFQH ILKDVPQDHC SIILPGVKGF EIAALLQYMY TGETTVTKSQ EPEILRTAKE 120
  121 LQVKGLYDNL MKFNHASVTP TSSSGAGGAK PQNGSASNHS SSVISTSTHI SPSAAISSSC 180
  181 SPPPPPQFGY QPGYSHYPQQ QPMSASQIPA GEAPLTPTQA TPHSAASGAG EAGGQWPLTP 240
  241 SAAAAMLNSV YESAADMNPL KRKKLSAISS MLLSGNRDTP ILRNVLAQAN PADSSQPGPM 300
  301 NANGEKTPTH PHQNTQLPAG LGVSGGERNH SFNGSDYGGD KEPLSPYTDR SFEEETGQSG 360
  361 GKKPEWKRYK QYTRADMMCA IQAVREGMSA LQASRKYGLP SRTLYDKVRK LNITTGRGTH 420
  421 RTPKRSPPGA ESSQGFSYSA AAAAAAHNYG HGHGHHSEVK RDQKVDHVPA HHGMPPTIPP 480
  481 SAAALLDHAF LQQALENRGG DMAGREALHA MALAAAAHAA ANRLSSSPAE MDQRSNGHGM 540
  541 RSPSPQGRHY PHEQEAMDLE MEKHEQNIIK RERDQDERED ADDEEDHEQE HVEDLSLARK 600
  601 ERPPSPYSPQ PTEAGAGVIM HASSASANGK DHVDYPSSPQ FVPIGLKREL MEGEDAQARA 660
  661 D

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..190] PSI-BLAST 37.522879 No description for 2nn2A was found.
    2 View Details [191..327] deduced N/A No confident structure predictions are available.
    3 View Details [328..425] FFAS03 2.14 Solution structures of the HTH domain of human LCoR protein
    4 View Details [426..527] deduced N/A No confident structure predictions are available.
    5 View Details [528..661] MSA 4.170996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  4.86538715425734 bayes_pls_golite062009
  • DNA binding
    		•  4.40186699787632 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.28652307290136 bayes_pls_golite062009
  • transcription factor activity
    		•  3.78935192723648 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.3280771187468 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.25454589469681 bayes_pls_golite062009
  • transcription activator activity
    		•  2.92652250400688 bayes_pls_golite062009
  • binding
    		•  2.92574888336072 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.91588376840709 bayes_pls_golite062009
  • protein binding
    		•  1.84594855626241 bayes_pls_golite062009
  • chromatin binding
    		•  1.46954724788757 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.44773725829085 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.30723796612579 bayes_pls_golite062009
  • transcription factor binding
    		•  1.24678737091956 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.691780246385357 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle