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Protein Overview: elk-PA

General Information:
Name(s) found: elk-PA / FBpp0085981 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene eag-like K<sup>+</sup> channel is referred to in FlyBase by the symbol Dmel\elk (CG5076, FBgn0011589). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:13761452..13813097. It has the cytological map location 54F4-55A2. It is reported to have molecular function</span>: voltage-gated potassium channel activity; potassium channel activity. It is reported to be involved in the biological process</span>: potassium ion transport. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1284 amino acids

    Gene Ontology:
    Cellular Component: voltage-gated potassium channel complex [NAS]
    membrane [IEA]
    Biological Process: potassium ion transport [IEA][NAS]
    transmembrane transport [IEA]
    two-component signal transduction system (phosphorelay) [IEA]
    regulation of transcription, DNA-dependent [IEA]
    Molecular Function: two-component sensor activity [IEA]
    voltage-gated potassium channel activity [IEA][NAS]
    potassium channel activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPARKGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQANGNP IVYCSDGFVD LTGYSRAQIM  60
   61 QKGCSCHFLY GPDTKEEHKQ QIEKSLSNKM ELKLEVIFYK KEGAPFWCLF DIVPIKNEKR 120
  121 DVVLFLASHK DITHTKMLEM NVNEECDSVF ALTAALLGAR FRAGSNAGML GLGGLPGLGG 180
  181 PAASDGDTEA GEGNNLDVPA GCNMGRRRSR AVLYQLSGHY KPEKGGVKTK LKLGNNFMHS 240
  241 TEAPFPEYKT QSIKKSRLIL PHYGVFKGIW DWVILVATFY VALMVPYNAA FAKADRQTKV 300
  301 SDVIVEALFI VDILLNFRTT FVSRKGEVVS NSKQIAINYL RGWFALDLLA ALPFDHLYAS 360
  361 DLYDGEDSHI HLVKLTRLLR LARLLQKIDR YSQHTAMILT LLMFSFTLAA HWLACIWYVI 420
  421 AVKEYEWFPE SNIGWLQLLA ERKNASVAIL TTAETYSTAL YFTFTSLTSV GFGNVSANTT 480
  481 AEKVFTIIMM LIGALMHAVV FGNVTAIIQR MYSRRSLYES KWRDLKDFVA LHNMPKELKQ 540
  541 RIEDYFQTSW SLSHGIDIYE TLREFPEELR GDVSMHLHRE ILQLPIFEAA SQGCLKLLSL 600
  601 HIKTNFCAPG EYLIHKGDAL NYIYYLCNGS MEVIKDDMVV AILGKGDLVG SDINVHLVAT 660
  661 SNGQMTATTN SAGQDVVVRS SSDIKALTYC DLKCIHMGGL VEVLRLYPEY QQQFANDIQH 720
  721 DLTCNLREGY ENQDSDIGPS FPLPSISEDD ENREEAEEGG KGEKENGGGP PSGASPLHNI 780
  781 SNSPLHATRS PLLGMGSPRN QRLHQRGRSL ITLRETNKRH RTLNAACSLD RGSFEEPEPL 840
  841 EEEQSSGGKR PSLERLDSQV STLHQDVAQL SAEVRNAISA LQEMTFTSNA MTSHSSLKFP 900
  901 PARSIPNISG VAGTRSGVAV EHGLMGGVLA AAELAAMQRS SSHPPEVWGR DVQLPTSNTA 960
  961 SSKAPSPVEP KKTMTSRSSQ TDFYRIDFPT FERFVLANPR LVLGLLGIEP AIKNEMDLLQ1020
 1021 QKQTLQISPL NTIDECVSPS DHNLASSKER LITSSAVPTP GRIYPPLDDE NSNDFRWTMK1080
 1081 HSASHHSCCK STDALLSPEE QPPISILPVD ATPAPSVQEV RSSKRSLRKS TSGSNSSLSS1140
 1141 SSSSSNSCLV SQSTGNLTTT NASVHCSNSS QSVASVATTR RASWKLQHSR SGEYRRLSEA1200
 1201 TAEYSPPAKT PLPVAGVSYG GDEEESVELL GPRRNSRPIL LGVSQNQGQG QAMNFRFSAG1260
 1261 DADKLEKGLR GLPSTRSLRD PSSK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..72] PSI-BLAST 26.69897 Erg potassium channel, N-terminal domain
    2 View Details [73..588] PSI-BLAST 3.154902 Botulinum neurotoxin
    3 View Details [589..739] PSI-BLAST 42.0 HCN2J 443-645 in the presence of cGMP
    4 View Details [740..981] deduced N/A No confident structure predictions are available.
    5 View Details [982..1188] MSA 3.375995 View MSA. No confident structure predictions are available.
    6 View Details [1189..1284] MSA 4.339995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • substrate-specific transmembrane transporter activity
    		•  2.4673993239115 bayes_pls_golite062009
  • amine binding
    		•  1.56690065078434 bayes_pls_golite062009
  • binding
    		•  1.31086473286665 bayes_pls_golite062009
  • transporter activity
    		•  1.29150662073327 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07075219961504 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.801327928563072 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.703854404841118 bayes_pls_golite062009
  • protein binding
    		•  0.505130802921086 bayes_pls_golite062009
  • sugar binding
    		•  0.466177845826757 bayes_pls_golite062009
    		• 0.394278984078131 bayes_pls_golite062009
  • channel regulator activity
    		•  0.37785202181286 bayes_pls_golite062009
  • receptor activity
    		•  0.256839032951381 bayes_pls_golite062009
  • signal transducer activity
    		•  0.149715597443623 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.149715597443623 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.0106003018506309 bayes_pls_golite062009
    3
    Term Confidence Notes
  • cyclic nucleotide-gated ion channel activity
    		•  11.4016635726548 bayes_pls_golite062009
  • intracellular cyclic nucleotide activated cation channel activity
    		•  11.4016635726548 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  10.0964834385956 bayes_pls_golite062009
  • cation channel activity
    		•  9.88287212109635 bayes_pls_golite062009
  • ion channel activity
    		•  9.4846197809463 bayes_pls_golite062009
  • channel activity
    		•  9.25176207085973 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  9.25176207085973 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  9.2472549851376 bayes_pls_golite062009
  • intracellular cGMP activated cation channel activity
    		•  9.19973076787954 bayes_pls_golite062009
  • gated channel activity
    		•  9.19042473454294 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  8.67936023319976 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  8.65591260847522 bayes_pls_golite062009
  • potassium channel activity
    		•  8.63993986153386 bayes_pls_golite062009
  • cGMP binding
    		•  7.7575871125398 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  7.73925918789438 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  7.67206802696522 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  7.63607783812958 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  7.63607783812958 bayes_pls_golite062009
  • cyclic nucleotide binding
    		•  7.37322432929433 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  6.98507387897677 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  5.54400173845933 bayes_pls_golite062009
  • GMP binding
    		•  5.49455172024846 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  5.34760703274696 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  5.1138025954757 bayes_pls_golite062009
  • transporter activity
    		•  3.30740141256752 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.24402760485462 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.22443361822344 bayes_pls_golite062009
  • intracellular cAMP activated cation channel activity
    		•  3.18381716104784 bayes_pls_golite062009
  • binding
    		•  1.14074551098763 bayes_pls_golite062009
  • protein binding
    		•  0.560659365968498 bayes_pls_golite062009
  • signal transducer activity
    		•  0.202809682876964 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.202809682876964 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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