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Protein Overview: debcl-PA

General Information:
Name(s) found: debcl-PA / FBpp0085443 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • The gene death executioner Bcl-2 homologue is referred to in FlyBase by the symbol Dmel\debcl (CG33134, FBgn0029131). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:2536246..2540336. It has the cytological map location 42B2-42C1. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process</span>: apoptosis; induction of apoptosis; negative regulation of neuron apoptosis; DNA damage response, signal transduction resulting in induction of apoptosis. 22 alleles are reported. The phenotypes of these alleles are annotated with: eye disc; eye; salivary gland; interommatidial bristle; eye photoreceptor cell; wing; ommatidium; pigment cell. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 300 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial outer membrane [ISS]
    mitochondrial envelope [IDA]
    Biological Process: anti-apoptosis [ISS]
    induction of apoptosis [IMP][ISS]
    apoptosis [IEP][IMP][ISS][NAS][TAS]
    DNA damage response, signal transduction resulting in induction of apoptosis [IMP]
    regulation of mitochondrial membrane permeability [ISS]
    negative regulation of neuron apoptosis [IMP]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPTTSPPPK LAKFKSSSLD HEIYTANRRG TIATASSDWK ALRGGVGGGA GGPGSVPNPS  60
   61 NGRSLHAGGP MTRAASTSSL ASSTRTMTNY QEYKMDIINQ GKCLCGQYIR ARLRRAGVLN 120
  121 RKVTQRLRNI LDPGSSHVVY EVFPALNSMG EELERMHPRV YTNISRQLSR APFGELEDSD 180
  181 MAPMLLNLVA KDLFRSSITW GKIISIFAVC GGFAIDCVRQ GHFDYLQCLI DGLAEIIEDD 240
  241 LVYWLIDNGG WLGLSRHIRP RVGEFTFLGW LTLFVTISAG AYMVSNVCRR IGGQLYSLLF 300
  301

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..300] PSI-BLAST 46.045757 Proapoptotic molecule Bax

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • BH3 domain binding
    		•  6.43959332849655 bayes_pls_golite062009
  • BH domain binding
    		•  5.99641721040442 bayes_pls_golite062009
  • death domain binding
    		•  4.8394058973128 bayes_pls_golite062009
  • protein binding
    		•  3.0436105050182 bayes_pls_golite062009
  • binding
    		•  2.59561200514645 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  2.08481887850766 bayes_pls_golite062009
  • protein dimerization activity
    		•  2.02084894683525 bayes_pls_golite062009
  • transporter activity
    		•  1.34634197931778 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.13326310611172 bayes_pls_golite062009
  • caspase inhibitor activity
    		•  1.1117246440194 bayes_pls_golite062009
  • protein channel activity
    		•  0.982298120724541 bayes_pls_golite062009
  • identical protein binding
    		•  0.674037751773281 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.628766142173243 bayes_pls_golite062009
  • protein transporter activity
    		•  0.472388332659106 bayes_pls_golite062009
  • cysteine-type endopeptidase inhibitor activity
    		•  0.450804017765264 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.401540458357579 bayes_pls_golite062009
  • caspase regulator activity
    		•  0.287831586746878 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.0896822837562903 bayes_pls_golite062009
  • transcription activator activity
    		•  0.055978531291871 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0304736434950499 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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