General Information: |
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Name(s) found: |
PTPRF_RAT
[Swiss-Prot]
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Description(s) found:
SHOW ONLY BEST |
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Organism: | Rattus norvegicus |
Length: | 1898 amino acids |
Gene Ontology: |
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Cellular Component: |
membrane fraction
[IDA]
growth cone [IDA] insoluble fraction [IDA] endosome [IDA] excitatory synapse [IDA] microsome [IDA] integral to membrane [IEA] neuronal cell body [IDA] neuron projection [IDA] plasma membrane [IDA] |
Biological Process: |
negative regulation of cell proliferation
[IMP]
protein amino acid dephosphorylation [IDA] nervous system development [IDA] cell adhesion [IEA] homophilic cell adhesion [IDA] negative regulation of epidermal growth factor receptor signaling pathway [IMP] negative regulation of insulin receptor signaling pathway [IMP] positive regulation of neuron apoptosis [IMP] negative regulation of cytokine-mediated signaling pathway [IMP] negative regulation of nerve growth factor receptor signaling pathway [IMP] positive regulation of apoptosis [IDA] regulation of synapse structure and activity [IMP] negative regulation of cell projection organization [IMP] positive regulation of dendrite morphogenesis [IMP] |
Molecular Function: |
protein tyrosine phosphatase activity
[UNKNOWN][IDA][ISS]
transmembrane receptor protein tyrosine phosphatase activity [IDA] receptor activity [IEA] insulin receptor binding [IDA] phosphate binding [IDA] receptor tyrosine kinase binding [IPI] hydrolase activity [IEA] |
Sequence: |
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Sequence: [PDR BLAST] [ProtParam] |
1 11 21 31 41 51 | | | | | | 1 MAPEPAPGRR MVPLVPALVM LGLMAGAHGD SKPVFVKVPE DQIGLSGGVA SFVCQATGEP 60 61 KPRITWMKKG KKVSSQRFEV IEFDDGAGSV LRIQPLRVQR DEAIYECTAT NSLGEINTSA 120 121 KLSVLEEDQL PSGFPTIDMG PQLKVVEKAR TATMLCAAGG NPDPEISWFK DFLPVDPASS 180 181 NGRIKQLRSG ALQIESSEES DQGKYECVAT NSAGTRYSAP ANLYVRVRRV APRFSIPPSS 240 241 QEVMPGGNVN LTCVAVGAPM PYVKWMMGAE ELTKEDEMPV GRNVLELSNV MRSANYTCVA 300 301 ISSLGMIEAT AQVTVKALPK PPIDLVVTET TATSVTLTWD SGNTEPVSFY GIQYRAAGTD 360 361 GPFQEVDGVA STRYSIGGLS PFSEYAFRVL AVNSIGRGPP SEAVRARTGE QAPSSPPRRV 420 421 QARMLSASTM LVQWEPPEEP NGLVRGYRVY YTPDSRRPLS AWHKHNTDAG LLTTVGSLLP 480 481 GITYSLRVLA FTAVGDGPPS PTIQVKTQQG VPAQPADFQA KAESDTRIQL SWLLPPQERI 540 541 IKYELVYWAA EDEGQQHKVT FDPTSSYTLE DLKPDTLYHF QLAARSDLGV GVFTPTVEAC 600 601 TAQSTPSAPP QKVTCVSTGS TTVRVSWVPP PADSRNGIIT QYSVAYEAVD GEDRKRHVVD 660 661 GISREHSSWD LLGLEKWTEY RVWVRAHTDV GPGPESSPVL VRTDEDVPSG PPRKVEVEPL 720 721 NSTAVHVSWK LPVPNKQHGQ IRGYQVTYVR LENGEPRGQP IIQDVMLAEA QETTISGLTP 780 781 ETTYSITVAA YTTKGDGARS KPKVVTTTGA VPGRPTMMVS TTAMHTALLQ WHPPKELPGE 840 841 LLGYRLQYRR ADEARPNTID FGKDDQHFTV TGLHKGATYI FRLAAKNRAG PGEEFEKEIT 900 901 TPEDAPSGFP QNLRVTGLTT STTELAWDPP VLAERNGRIT NYTVVYRDIN SQHELQNVTG 960 961 DVHLTLLGLK PDTTYDIKVR AHTSKGAGPL SPSIQSRTMP MEQVFAKNFR VAAAMKTSVL1020 1021 LSWEVPDSYK SAVPFKILYN GQSVEVDGHS MRKLIADLQP NTEYSFVLMN RGTSAGGLQH1080 1081 LVSIRTAPDL LPQKPLPASA FIEDGRFSLS MPQVQDPSLV RWFYIVVVPI DRVGGNLLAP1140 1141 RWSTPEELEL DELLEAIEQG EEKQRRRRRQ AERLKPYVAA QVDELPETFT LGDKKNYRGF1200 1201 YNRPLSPDLS YQCFVLASLK EPMDQKRYAS SPYSDEIVVQ VTPAQQQEEP EMLWVTGPVL1260 1261 AVILIILIVI AILLFKRKRT HSPSSKDEQS IGLKDSLLAH SSDPVEMRRL NYQTPGMRDH1320 1321 PPIPITDLAD NIERLKANDG LKFSQEYESI DPGQQFTWEN SNSEVNKPKN RYANVIAYDH1380 1381 SRVLLTSIDG VPGSDYINAN YIDGYRKQNA YIATQGPLPE TMGDFWRMVW EQRIATVVMM1440 1441 TRLEEKSRVK CDQYWPARGT ETYGLIQVTL VDTVELATYT MRTFALHKSG SSEKRELRQF1500 1501 QFMAWPDHGV PEYPTPILAF LRRVKACNPL DAGPMVVHCS AGVGRTGCFI VIDAMLERMK1560 1561 HEKTVDIYGH VTCMRSQRNY MVQTEDQYVF IHEALLEAAM CGHTEVLARN LYAHIQKLGQ1620 1621 VPPGESVTAM ELEFKLLAGS KARASRFISA NLPCNKFKNR LVNIMPYELT RVCLQPIRGV1680 1681 EGSDYINASF LDGYRQQKAY IATQGPLAES TEDFWRMLWE HNSTIIVMLT KLREMGREKC1740 1741 HQYWPAERSA RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTIRQFQ FTDWPEQGVP1800 1801 KTGEGFIDFI GQVHKTKEQF GQDGPITVHC SAGVGRTGVF ITLSIVLERM RYEGVVDMFQ1860 1861 TVKTLRTQRP AMVQTEDQYQ LCYRAALEYL GSFDHYAT |
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