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Protein Overview: SMAD4_RAT

General Information:
Name(s) found: SMAD4_RAT [Swiss-Prot]
Description(s) found:
Found 22 descriptions.
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  • Mothers against decapentaplegic homolog 4 OS=Rattus norvegicus GN=Smad4 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 552 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IDA]
    transcription factor complex [UNKNOWN][IEA]
    cytoplasm [UNKNOWN][IDA]
    cytosol [UNKNOWN]
    activin responsive factor complex [UNKNOWN][IEA]
    protein complex [IDA]
    [NOT]nucleolus [UNKNOWN]
    intracellular [IEA]
    nucleoplasm [UNKNOWN]
    Biological Process: cell proliferation [UNKNOWN]
    endoderm development [UNKNOWN][IEA]
    negative regulation of cell proliferation [UNKNOWN][IEA]
    palate development [IEA]
    transforming growth factor beta receptor signaling pathway [UNKNOWN][IEA]
    mesoderm development [UNKNOWN][IEA]
    anterior/posterior pattern formation [UNKNOWN][IEA]
    positive regulation of transcription [UNKNOWN]
    negative regulation of cell death [IEA]
    regulation of transforming growth factor-beta2 production [UNKNOWN][IEA]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    formation of anatomical boundary [UNKNOWN][IEA]
    positive regulation of epithelial to mesenchymal transition [IEA]
    response to hypoxia [UNKNOWN][IEA]
    negative regulation of transcription, DNA-dependent [UNKNOWN][IEA]
    in utero embryonic development [UNKNOWN][IEA]
    kidney development [UNKNOWN][IEA]
    negative regulation of cell growth [UNKNOWN][IEA]
    positive regulation of transcription, DNA-dependent [UNKNOWN]
    gastrulation with mouth forming second [UNKNOWN][IEA]
    BMP signaling pathway [UNKNOWN][IEA]
    neuron fate commitment [UNKNOWN][IEA]
    positive regulation of SMAD protein nuclear translocation [IEA]
    somite rostral/caudal axis specification [UNKNOWN][IEA]
    SMAD protein complex assembly [UNKNOWN][IEA]
    tissue morphogenesis [UNKNOWN][IEA]
    SMAD protein signal transduction [UNKNOWN][IEA]
    regulation of transcription, DNA-dependent [IEA]
    developmental growth [UNKNOWN][IEA]
    regulation of cell proliferation [UNKNOWN]
    regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    gastrulation [UNKNOWN]
    ureteric bud development [UNKNOWN][IEA]
    branching involved in ureteric bud morphogenesis [UNKNOWN][IEA]
    regulation of binding [UNKNOWN][IEA]
    regulation of transforming growth factor beta receptor signaling pathway [UNKNOWN]
    positive regulation of pathway-restricted SMAD protein phosphorylation [IEA]
    positive regulation of transforming growth factor beta receptor signaling pathway [UNKNOWN][IEA]
    Molecular Function: identical protein binding [UNKNOWN]
    protein homodimerization activity [UNKNOWN][IEA]
    sequence-specific DNA binding [UNKNOWN]
    chromatin binding [UNKNOWN][IEA]
    DNA binding [UNKNOWN][IDA]
    transcription factor activity [UNKNOWN][IEA]
    protein binding [UNKNOWN][IDA][IEA][IPI]
    collagen binding [UNKNOWN][IEA]
    SMAD binding [IPI]
    transforming growth factor beta receptor, common-partner cytoplasmic mediator activity [UNKNOWN][IEA]
    R-SMAD binding [UNKNOWN][IEA]
    promoter binding [UNKNOWN][IEA]
    transcription activator activity [UNKNOWN][IEA]
    I-SMAD binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDNMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK KDELDSLITA  60
   61 ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR WPDLHKNELK HVKYCQYAFD 120
  121 LKCDSVCVNP YHYERVVSPG IDLSGLTLQS NAPPSMLVKD EYVHDFEGQP SLPTEGHSIQ 180
  181 TIQHPPSNRA STETYSAPAL LAPSESNATS TTNFPNIPVA STSQPASILA GSHSEGLLQI 240
  241 ASGPQPGQQQ NGFTAQPATY HHNSTTTWTG SRTAPYTPNL PHHQNGHLQH HPPMPPHPGH 300
  301 YWPVHNELAF QPPISNHPAP EYWCSIAYFE MDVQVGETFK VPSSCPIVTV DGYVDPSGGD 360
  361 RFCLGQLSNV HRTEAIERAR LHIGKGVQLE CKGEGDVWVR CLSDHAVFVQ SYYLDREAGR 420
  421 APGDAVHKIY PSAYIKVFDL RQCHRQMQQQ AATAQAAAAA QAAAVAGNIP GPGSVGGIAP 480
  481 AISLSAAAGI GVDDLRRLCI LRMSFVKGWG PDYPRQSIKE TPCWIEIHLH RALQLLDEVL 540
  541 HTMPIADPQP LD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle