General Information: |
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Name(s) found: |
SMAD4_RAT
[Swiss-Prot]
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Description(s) found:
SHOW ONLY BEST |
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Organism: | Rattus norvegicus |
Length: | 552 amino acids |
Gene Ontology: |
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Cellular Component: |
nucleus
[UNKNOWN][IDA]
transcription factor complex [UNKNOWN][IEA] cytoplasm [UNKNOWN][IDA] cytosol [UNKNOWN] activin responsive factor complex [UNKNOWN][IEA] protein complex [IDA] [NOT]nucleolus [UNKNOWN] intracellular [IEA] nucleoplasm [UNKNOWN] |
Biological Process: |
cell proliferation
[UNKNOWN]
endoderm development [UNKNOWN][IEA] negative regulation of cell proliferation [UNKNOWN][IEA] palate development [IEA] transforming growth factor beta receptor signaling pathway [UNKNOWN][IEA] mesoderm development [UNKNOWN][IEA] anterior/posterior pattern formation [UNKNOWN][IEA] positive regulation of transcription [UNKNOWN] negative regulation of cell death [IEA] regulation of transforming growth factor-beta2 production [UNKNOWN][IEA] positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA] formation of anatomical boundary [UNKNOWN][IEA] positive regulation of epithelial to mesenchymal transition [IEA] response to hypoxia [UNKNOWN][IEA] negative regulation of transcription, DNA-dependent [UNKNOWN][IEA] in utero embryonic development [UNKNOWN][IEA] kidney development [UNKNOWN][IEA] negative regulation of cell growth [UNKNOWN][IEA] positive regulation of transcription, DNA-dependent [UNKNOWN] gastrulation with mouth forming second [UNKNOWN][IEA] BMP signaling pathway [UNKNOWN][IEA] neuron fate commitment [UNKNOWN][IEA] positive regulation of SMAD protein nuclear translocation [IEA] somite rostral/caudal axis specification [UNKNOWN][IEA] SMAD protein complex assembly [UNKNOWN][IEA] tissue morphogenesis [UNKNOWN][IEA] SMAD protein signal transduction [UNKNOWN][IEA] regulation of transcription, DNA-dependent [IEA] developmental growth [UNKNOWN][IEA] regulation of cell proliferation [UNKNOWN] regulation of transcription from RNA polymerase II promoter [UNKNOWN] gastrulation [UNKNOWN] ureteric bud development [UNKNOWN][IEA] branching involved in ureteric bud morphogenesis [UNKNOWN][IEA] regulation of binding [UNKNOWN][IEA] regulation of transforming growth factor beta receptor signaling pathway [UNKNOWN] positive regulation of pathway-restricted SMAD protein phosphorylation [IEA] positive regulation of transforming growth factor beta receptor signaling pathway [UNKNOWN][IEA] |
Molecular Function: |
identical protein binding
[UNKNOWN]
protein homodimerization activity [UNKNOWN][IEA] sequence-specific DNA binding [UNKNOWN] chromatin binding [UNKNOWN][IEA] DNA binding [UNKNOWN][IDA] transcription factor activity [UNKNOWN][IEA] protein binding [UNKNOWN][IDA][IEA][IPI] collagen binding [UNKNOWN][IEA] SMAD binding [IPI] transforming growth factor beta receptor, common-partner cytoplasmic mediator activity [UNKNOWN][IEA] R-SMAD binding [UNKNOWN][IEA] promoter binding [UNKNOWN][IEA] transcription activator activity [UNKNOWN][IEA] I-SMAD binding [UNKNOWN] |
Sequence: |
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Sequence: [PDR BLAST] [ProtParam] |
1 11 21 31 41 51 | | | | | | 1 MDNMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK KDELDSLITA 60 61 ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR WPDLHKNELK HVKYCQYAFD 120 121 LKCDSVCVNP YHYERVVSPG IDLSGLTLQS NAPPSMLVKD EYVHDFEGQP SLPTEGHSIQ 180 181 TIQHPPSNRA STETYSAPAL LAPSESNATS TTNFPNIPVA STSQPASILA GSHSEGLLQI 240 241 ASGPQPGQQQ NGFTAQPATY HHNSTTTWTG SRTAPYTPNL PHHQNGHLQH HPPMPPHPGH 300 301 YWPVHNELAF QPPISNHPAP EYWCSIAYFE MDVQVGETFK VPSSCPIVTV DGYVDPSGGD 360 361 RFCLGQLSNV HRTEAIERAR LHIGKGVQLE CKGEGDVWVR CLSDHAVFVQ SYYLDREAGR 420 421 APGDAVHKIY PSAYIKVFDL RQCHRQMQQQ AATAQAAAAA QAAAVAGNIP GPGSVGGIAP 480 481 AISLSAAAGI GVDDLRRLCI LRMSFVKGWG PDYPRQSIKE TPCWIEIHLH RALQLLDEVL 540 541 HTMPIADPQP LD |
NOT SHOWING SINGLE HITS. [ Show Single Hits ]
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Protein predicted to be: | GLOBULAR (No transmembrane regions or signal peptide) |
Confidence of classification: | 0.87 |
Source: Reynolds et al. (2008)