Protein Overview: gi|18497288, gi|...

General Information:
Name(s) found:	gi\|18497288 [NCBI NR] gi\|18466810 [NCBI NR]
Description(s) found: Found 25 descriptions. SHOW ALL	gi\|18497288\|ref\|NP_066548.2\| latent transforming growth factor beta binding protein 3 isoform 2 [Homo sapiens] [NCBI NR] gi\|18466810\|gb\|AAF62352.3\|AF135960_1 latent transforming growth factor beta binding protein 3 [Homo sapiens] [NCBI NR]
Organism:	Homo sapiens
Length:	1256 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGPRGAAGG LAPEMRGAGA AGLLALLLLL LLLLLGLGGR VEGGPAGERG AGGGGALARE  60
   61 RFKVVFAPVI CKRTCLKGQC RDSCQQGSNM TLIGENGHST DTLTGSGFRV VVCPLPCMNG 120
  121 GQCSSRNQCL CPPDFTGRFC QVPAGGAGGG TGGSGPGLSR TGALSTGALP PLAPEGDSVA 180
  181 SKHAIYAVQV IADPPGPGEG PPAQHAAFLV PLGPGQISAE VQAPPPVVNV RVHHPPEASV 240
  241 QVHRIESSNA ESAAPSQHLL PHPKPSHPRP PTQKPLGRCF QDTLPKQPCG SNPLPGLTKQ 300
  301 EDCCGSIGTA WGQSKCHKCP QLQYTGVQKP GPVRGEVGAD CPQGYKRLNS THCQDINECA 360
  361 MPGVCRHGDC LNNPGSYRCV CPPGHSLGPS RTQCIADKPE EKSLCFRLVS PEHQCQHPLT 420
  421 TRLTRQLCCC SVGKAWGARC QRCPTDGTAA FKEICPAGKG YHILTSHQTL TIQGESDFSL 480
  481 FLHPDGPPKP QQLPESPSQA PPPEDTEEER GVTTDSPVSE ERSVQQSHPT ATTTPARPYP 540
  541 ELISRPSPPT MRWFLPDLPP SRSAVEIAPT QVTETDECRL NQNICGHGEC VPGPPDYSCH 600
  601 CNPGYRSHPQ HRYCVDVNEC EAEPCGPGRG ICMNTGGSYN CHCNRGYRLH VGAGGRSCVD 660
  661 LNECAKPHLC GDGGFCINFP GHYKCNCYPG YRLKASRPPV CEDIDECRDP SSCPDGKCEN 720
  721 KPGSFKCIAC QPGYRSQGGG ACRDVNECAE GSPCSPGWCE NLPGSFRCTC AQGYAPAPDG 780
  781 RSCLDVDECE AGDVCDNGIC SNTPGSFQCQ CLSGYHLSRD RSHCEDIDEC DFPAACIGGD 840
  841 CINTNGSYRC LCPQGHRLVG GRKCQDIDEC SQDPSLCLPH GACKNLQGSY VCVCDEGFTP 900
  901 TQDQHGCEEV EQPHHKKECY LNFDDTVFCD SVLATNVTQQ ECCCSLGAGW GDHCEIYPCP 960
  961 VYSSAEFHSL CPDGKGYTQD NNIVNYGIPA HRDIDECMLF GSEICKEGKC VNTQPGYECY1020
 1021 CKQGFYYDGN LLECVDVDEC LDESNCRNGV CENTRGGYRC ACTPPAEYSP AQRQCLSPEE1080
 1081 MERAPERRDV CWSQRGEDGM CAGPLAGPAL TFDDCCCRQG RGWGAQCRPC PPRGAGSHCP1140
 1141 TSQSESNSFW DTSPLLLGKP PRDEDSSEED SDECRCVSGR CVPRPGGAVC ECPGGFQLDA1200
 1201 SRARCVDIDE CRELNQRGLL CKSERCVNTS GSFRCVCKAG FARSRPHGAC VPQRRR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MIS12	No Comments	Cheeseman, I.M., et al. (2004)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

No microscopy data found in the PDR for this protein.

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..211]	PSI-BLAST	4.39794	No description for 2gy5A was found.
2	View Details	[212..311]	deduced	N/A	No confident structure predictions are available.
3	View Details	[312..361]	FFAS03	2.39	Coagulation factor VIIa
4	View Details	[362..613]	FFAS03	4.11	Integrin binding cbEGF22-TB4-cbEGF33 fragment of human fibrillin-1, holo form.
5	View Details	[614..698]	PSI-BLAST	5.0	Fibrillin-1
6	View Details	[699..784]	FFAS03	2.78	Activated protein c (autoprothrombin IIa)
7	View Details	[785..867]	PSI-BLAST	3.69897	NMR STUDY OF A PAIR OF FIBRILLIN CA2+ BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAINS, MINIMIZED AVERAGE STRUCTURE
8	View Details	[868..1256]	PSI-BLAST	16.69897	Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

No functions predicted.

3

Term	Confidence	Notes
binding	1.36707749198024	bayes_pls_golite062009
structural constituent of bone	1.09446266124376	bayes_pls_golite062009
protein binding	0.193079522686232	bayes_pls_golite062009

4

No functions predicted.

5

Term	Confidence	Notes
receptor binding	4.60755835611133	bayes_pls_golite062009
growth factor activity	4.38305031783896	bayes_pls_golite062009
epidermal growth factor receptor binding	2.63546895705146	bayes_pls_golite062009
extracellular matrix structural constituent	2.25506386782176	bayes_pls_golite062009
binding	2.07793256968292	bayes_pls_golite062009
protein binding	1.71989387545809	bayes_pls_golite062009
glycosaminoglycan binding	1.59362625477231	bayes_pls_golite062009
heparin binding	1.18377533277052	bayes_pls_golite062009
polysaccharide binding	0.9177636847106	bayes_pls_golite062009
ErbB-3 class receptor binding	0.65339109098708	bayes_pls_golite062009
pattern binding	0.59201056851242	bayes_pls_golite062009
ErbB-2 class receptor binding	0.470263535896705	bayes_pls_golite062009

6

Term	Confidence	Notes
receptor binding	4.27252497280864	bayes_pls_golite062009
growth factor activity	3.99323701198118	bayes_pls_golite062009
extracellular matrix structural constituent	2.12504268450415	bayes_pls_golite062009
epidermal growth factor receptor binding	2.11629206230008	bayes_pls_golite062009
binding	1.98073403587238	bayes_pls_golite062009
protein binding	1.57046350131335	bayes_pls_golite062009
glycosaminoglycan binding	1.34029908248821	bayes_pls_golite062009
heparin binding	0.904794195857948	bayes_pls_golite062009
polysaccharide binding	0.683674808850842	bayes_pls_golite062009
pattern binding	0.377980933320322	bayes_pls_golite062009
ErbB-3 class receptor binding	0.0837042404322571	bayes_pls_golite062009

7

No functions predicted.

8

Term	Confidence	Notes
receptor binding	4.60755835611133	bayes_pls_golite062009
growth factor activity	4.38305031783896	bayes_pls_golite062009
epidermal growth factor receptor binding	2.63546895705146	bayes_pls_golite062009
extracellular matrix structural constituent	2.25506386782176	bayes_pls_golite062009
binding	2.07793256968292	bayes_pls_golite062009
protein binding	1.71989387545809	bayes_pls_golite062009
glycosaminoglycan binding	1.59362625477231	bayes_pls_golite062009
heparin binding	1.18377533277052	bayes_pls_golite062009
polysaccharide binding	0.9177636847106	bayes_pls_golite062009
ErbB-3 class receptor binding	0.65339109098708	bayes_pls_golite062009
pattern binding	0.59201056851242	bayes_pls_golite062009
ErbB-2 class receptor binding	0.470263535896705	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle