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View Structure Prediction Details

Protein: gi|18497288, gi|...
Organism: Homo sapiens
Length: 1256 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|18497288, gi|....

Description E-value Query
Range		 Subject
Range
h0004690 - null
LTBP3 - latent transforming growth factor beta binding protein 3
 0.0 [1..1256] [1..1303]
gi|47847408 - gi|47847408|dbj|BAD21376.1| mFLJ00070 protein [Mus musculus]
 0.0 [111..1256] [22..1167]
gi|114627589 - gi|114627589|ref|XP_520371.2| PREDICTED: notch1 isoform 2 [Pan troglodytes]
 0.0 [79..1254] [30..1102]

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Predicted Domain #1
Region A:
Residues: [1-211] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGPRGAAGG LAPEMRGAGA AGLLALLLLL LLLLLGLGGR VEGGPAGERG AGGGGALARE  60
   61 RFKVVFAPVI CKRTCLKGQC RDSCQQGSNM TLIGENGHST DTLTGSGFRV VVCPLPCMNG 120
  121 GQCSSRNQCL CPPDFTGRFC QVPAGGAGGG TGGSGPGLSR TGALSTGALP PLAPEGDSVA 180
  181 SKHAIYAVQV IADPPGPGEG PPAQHAAFLV P

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.39794
Match: 2gy5A
Description: No description for 2gy5A was found.

Predicted Domain #2
Region A:
Residues: [212-311] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGPGQISAEV QAPPPVVNVR VHHPPEASVQ VHRIESSNAE SAAPSQHLLP HPKPSHPRPP  60
   61 TQKPLGRCFQ DTLPKQPCGS NPLPGLTKQE DCCGSIGTAW

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [312-361] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GQSKCHKCPQ LQYTGVQKPG PVRGEVGADC PQGYKRLNST HCQDINECAM

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.39
Match: 1danL
Description: Coagulation factor VIIa
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.36707749198024 bayes_pls_golite062009
structural constituent of bone 1.09446266124376 bayes_pls_golite062009
protein binding 0.193079522686232 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [362-613] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGVCRHGDCL NNPGSYRCVC PPGHSLGPSR TQCIADKPEE KSLCFRLVSP EHQCQHPLTT  60
   61 RLTRQLCCCS VGKAWGARCQ RCPTDGTAAF KEICPAGKGY HILTSHQTLT IQGESDFSLF 120
  121 LHPDGPPKPQ QLPESPSQAP PPEDTEEERG VTTDSPVSEE RSVQQSHPTA TTTPARPYPE 180
  181 LISRPSPPTM RWFLPDLPPS RSAVEIAPTQ VTETDECRLN QNICGHGECV PGPPDYSCHC 240
  241 NPGYRSHPQH RY

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.11
Match: 1uzjA
Description: Integrin binding cbEGF22-TB4-cbEGF33 fragment of human fibrillin-1, holo form.
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [614-698] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CVDVNECEAE PCGPGRGICM NTGGSYNCHC NRGYRLHVGA GGRSCVDLNE CAKPHLCGDG  60
   61 GFCINFPGHY KCNCYPGYRL KASRP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1lmjA
Description: Fibrillin-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 4.60755835611133 bayes_pls_golite062009
growth factor activity 4.38305031783896 bayes_pls_golite062009
epidermal growth factor receptor binding 2.63546895705146 bayes_pls_golite062009
extracellular matrix structural constituent 2.25506386782176 bayes_pls_golite062009
binding 2.07793256968292 bayes_pls_golite062009
protein binding 1.71989387545809 bayes_pls_golite062009
glycosaminoglycan binding 1.59362625477231 bayes_pls_golite062009
heparin binding 1.18377533277052 bayes_pls_golite062009
polysaccharide binding 0.9177636847106 bayes_pls_golite062009
ErbB-3 class receptor binding 0.65339109098708 bayes_pls_golite062009
pattern binding 0.59201056851242 bayes_pls_golite062009
ErbB-2 class receptor binding 0.470263535896705 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [699-784] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVCEDIDECR DPSSCPDGKC ENKPGSFKCI ACQPGYRSQG GGACRDVNEC AEGSPCSPGW  60
   61 CENLPGSFRC TCAQGYAPAP DGRSCL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.78
Match: 1autL
Description: Activated protein c (autoprothrombin IIa)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 4.27252497280864 bayes_pls_golite062009
growth factor activity 3.99323701198118 bayes_pls_golite062009
extracellular matrix structural constituent 2.12504268450415 bayes_pls_golite062009
epidermal growth factor receptor binding 2.11629206230008 bayes_pls_golite062009
binding 1.98073403587238 bayes_pls_golite062009
protein binding 1.57046350131335 bayes_pls_golite062009
glycosaminoglycan binding 1.34029908248821 bayes_pls_golite062009
heparin binding 0.904794195857948 bayes_pls_golite062009
polysaccharide binding 0.683674808850842 bayes_pls_golite062009
pattern binding 0.377980933320322 bayes_pls_golite062009
ErbB-3 class receptor binding 0.0837042404322571 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [785-867] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVDECEAGDV CDNGICSNTP GSFQCQCLSG YHLSRDRSHC EDIDECDFPA ACIGGDCINT  60
   61 NGSYRCLCPQ GHRLVGGRKC QDI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.69897
Match: 1emnA
Description: NMR STUDY OF A PAIR OF FIBRILLIN CA2+ BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAINS, MINIMIZED AVERAGE STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [868-1256] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DECSQDPSLC LPHGACKNLQ GSYVCVCDEG FTPTQDQHGC EEVEQPHHKK ECYLNFDDTV  60
   61 FCDSVLATNV TQQECCCSLG AGWGDHCEIY PCPVYSSAEF HSLCPDGKGY TQDNNIVNYG 120
  121 IPAHRDIDEC MLFGSEICKE GKCVNTQPGY ECYCKQGFYY DGNLLECVDV DECLDESNCR 180
  181 NGVCENTRGG YRCACTPPAE YSPAQRQCLS PEEMERAPER RDVCWSQRGE DGMCAGPLAG 240
  241 PALTFDDCCC RQGRGWGAQC RPCPPRGAGS HCPTSQSESN SFWDTSPLLL GKPPRDEDSS 300
  301 EEDSDECRCV SGRCVPRPGG AVCECPGGFQ LDASRARCVD IDECRELNQR GLLCKSERCV 360
  361 NTSGSFRCVC KAGFARSRPH GACVPQRRR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.69897
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 4.60755835611133 bayes_pls_golite062009
growth factor activity 4.38305031783896 bayes_pls_golite062009
epidermal growth factor receptor binding 2.63546895705146 bayes_pls_golite062009
extracellular matrix structural constituent 2.25506386782176 bayes_pls_golite062009
binding 2.07793256968292 bayes_pls_golite062009
protein binding 1.71989387545809 bayes_pls_golite062009
glycosaminoglycan binding 1.59362625477231 bayes_pls_golite062009
heparin binding 1.18377533277052 bayes_pls_golite062009
polysaccharide binding 0.9177636847106 bayes_pls_golite062009
ErbB-3 class receptor binding 0.65339109098708 bayes_pls_golite062009
pattern binding 0.59201056851242 bayes_pls_golite062009
ErbB-2 class receptor binding 0.470263535896705 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle