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Protein Overview: ALG8

General Information:
Name(s) found: ALG8 / YOR067C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 577 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IMPLink to PubMed article][ISSLink to PubMed article]
    Biological Process: oligosaccharide-lipid intermediate assembly [IMPLink to PubMed article]
    protein amino acid N-linked glycosylation [IMPLink to PubMed article]
    dolichol-linked oligosaccharide biosynthetic process [TASLink to PubMed article]
    Molecular Function: dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKGDRSRQNM AVTKKAKLKK NDEPKKVLKT AATEKGEGSK RYSLWNFWIS TLFLKLLLIP  60
   61 DYFSTDFDVH RNWLAITNKL PISEWYYEHT SQWTLDYPPF FAYFEWFLSQ FVPKSVRDDG 120
  121 CLDIVEIGKF GLPTIVFQRL TVIFSEILLF VILQIYINTT KLSERSQSFV VASSIVLSPG 180
  181 FLIIDHIHFQ YNGFLFAILI GSIVAAKNKR YILCAVLYTT AICFKHIFLY LAPCYFVFLL 240
  241 RAYVLNVNNF KFKSYKDFLF LIRWANLLKL ATVVVGIFTI CFLPFAHQMP QVLSRLFPFS 300
  301 RGLTHAYWAP NFWALYSFMD KILTTVMLKL PYVHTFATKF IKPPLIPQNI KEINERLAAN 360
  361 NNGSKGLVQD VFFVILPQIP PKLTFILTIF YQVLAVLPLL FDPSFKRFVG SLTLCGLASF 420
  421 LFGWHVHEKA IMLVIIPFTF LVGFDRRLLV PFMLVASAGY VSLYPLLYKG QDFFIKTLYT 480
  481 YVWCIIYFAA FRKTTKISSS VERRIFFLDR LALTYIFSLL PIVTVLQILD EVKWRYSFLQ 540
  541 KFEFLGLMIY SVYCSLGIIS SWFALSWLYN FDELLWQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ALG1 ALG2 ALG5 ALG6 ALG8 ALG9 DIE2 OST1 OST2 SWP1 WBP1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBP6 ALG8 1 Unpublished Fields Lab Data
    View Screen RED1 ALG8 1 Unpublished Fields Lab Data
    View Screen UBC12 ALG8 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..577] Pfam 284.886057 ALG6, ALG8 glycosyltransferase family No confident structure predictions are available.
    2 View Details [192..251] deduced N/A No confident structure predictions are available.
    3 View Details [252..378] MSA 2.063988 View MSA. No confident structure predictions are available.
    4 View Details [379..577] MSA 3.060983 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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