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Protein Overview: SHR5

General Information:
Name(s) found: SHR5 / YOL110W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 237 amino acids

    Gene Ontology:
    Cellular Component: extrinsic to endoplasmic reticulum membrane [IDALink to PubMed article]
    palmitoyltransferase complex [IPILink to PubMed article]
    Biological Process: protein amino acid palmitoylation [IDALink to PubMed article][IMPLink to PubMed article]
    protein localization [IMPLink to PubMed article]
    Ras protein signal transduction [IMPLink to PubMed article]
    Molecular Function: protein-cysteine S-palmitoleyltransferase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCDSHQKEED NANTSERALF FNYHEFSYSF YEDLGSEDAK PTEHDEDHKL CITHFPNVYA  60
   61 ARGSAEFQVT RVVRVPRRFD ESRSSLETPQ FSTQLPGSEP AAIVGDDGTS FVRCGRYDIG 120
  121 DHVFGCSSVS PLSEYLSAAE LAEVVHRVNG FLLREEGEVF GWRNLSGLLL DMLTGGLWSW 180
  181 VLGPLLSRPV FQESLALEQY VAQLNSPGGL LHERGVRLVL PRRSGCLSLD FVVPRPK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ALG13 ERF2 ERI1 PFA3 SHR5 SWF1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..237] deduced N/A No confident structure predictions are available.
    2 View Details [157..237] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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