Protein Overview: LYS9

General Information:
Name(s) found:	LYS9 / YNR050C [SGD]
Description(s) found: Found 34 descriptions. SHOW ALL	Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112 [SGD]
Organism:	Saccharomyces cerevisiae
Length:	446 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA ]
Biological Process:	lysine biosynthetic process via aminoadipic acid [TAS]
Molecular Function:	saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKNVLLLGS GFVAQPVIDT LAANDDINVT VACRTLANAQ ALAKPSGSKA ISLDVTDDSA  60
   61 LDKVLADNDV VISLIPYTFH PNVVKSAIRT KTDVVTSSYI SPALRELEPE IVKAGITVMN 120
  121 EIGLDPGIDH LYAVKTIDEV HRAGGKLKSF LSYCGGLPAP EDSDNPLGYK FSWSSRGVLL 180
  181 ALRNSAKYWK DGKIETVSSE DLMATAKPYF IYPGYAFVCY PNRDSTLFKD LYHIPEAETV 240
  241 IRGTLRYQGF PEFVKALVDM GMLKDDANEI FSKPIAWNEA LKQYLGAKST SKEDLIASID 300
  301 SKATWKDDED RERILSGFAW LGLFSDAKIT PRGNALDTLC ARLEELMQYE DNERDMVVLQ 360
  361 HKFGIEWADG TTETRTSTLV DYGKVGGYSS MAATVGYPVA IATKFVLDGT IKGPGLLAPY 420
  421 SPEINDPIMK ELKDKYGIYL KEKTVA

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		ENP1 LTV1 LYS9 YAR1
View Details	Gavin AC, et al. (2006)		GET4 LYS9 TRM11 TRM112
View Details	Gavin AC, et al. (2002)		GET4 LYS9 MTQ2 TRM11 TRM112 TRM9

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SKP1	LYS9	1	Unpublished Fields Lab Data
View Screen	PRP16	LYS9	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	LYS9	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..123] [395..420]	PSI-BLAST	1794.0	Saccharopine reductase
2	View Details	[124..253] [345..394] [421..446]	PSI-BLAST	1794.0	Saccharopine reductase
3	View Details	[254..344]	PSI-BLAST	1794.0	Saccharopine reductase

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2