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Protein Overview: SPC24

General Information:
Name(s) found: SPC24 / YMR117C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 213 amino acids

    Gene Ontology:
    Cellular Component: condensed nuclear chromosome, centromeric region [IGILink to PubMed article][IPILink to PubMed article]
    Ndc80 complex [IDALink to PubMed articleLink to PubMed article]
    condensed nuclear chromosome kinetochore [IDALink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Biological Process: microtubule nucleation [IPILink to PubMed article]
    chromosome segregation [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: structural constituent of cytoskeleton [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQKDNLLDN PVEFLKEVRE SFDIQQDVDA MKRIRHDLDV IKEESEARIS KEHSKVSESN  60
   61 KKLNAERINV AKLEGDLEYT NEESNEFGSK DELVKLLKDL DGLERNIVSL RSELDEKMKL 120
  121 YLKDSEIIST PNGSKIKAKV IEPELEEQSA VTPEANENIL KLKLYRSLGV ILDLENDQVL 180
  181 INRKNDGNID ILPLDNNLSD FYKTKYIWER LGK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) NUF2 SPC24 SPC25 TID3
    View Details (MIPS) Mewes HW, et al. (2004) BBP1 CDC31 CMD1 CNM67 KAR1 NUD1 NUF2 SPC105 SPC110 SPC24 SPC25 SPC29 SPC42 SPC72 TID3
    View Details Krogan NJ, et al. (2006) NUF2 SPC24 SPC25 TID3 YBR028C YDL073W
    View Details Gavin AC, et al. (2006) NUF2 SPC24 SPC25 TID3
    View Details Ho Y, et al. (2002) GCD11 GLT1 MET18 SPC24 SPC25
    View Details Qiu et al. (2008) AME1 BBP1 BIK1 CDC31 CNM67 KAR1 KAR3 MPS2 MTW1 NUF2 SPC105 SPC110 SPC19 SPC24 SPC25 SPC29 SPC34 SPC42 SPC72 SPC97 SPC98 STU1 STU2 TID3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TID3 No Comments Cheeseman IM, et al. (2002)
    View Run TID3 No Comments Cheeseman IM, et al. (2002)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SPC24 and SPC42 Huh WK, et al. (2003)
    View Data SPC24 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..213] deduced N/A No confident structure predictions are available.
    2 View Details [150..213] PSI-BLAST 30.0 No description for 2fv4B was found.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle