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Protein Overview: MEC3

General Information:
Name(s) found: MEC3 / YLR288C [SGD]
Description(s) found:
Found 27 descriptions.
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  • DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 474 amino acids

    Gene Ontology:
    Cellular Component: nucleus [TASLink to PubMed article]
    Biological Process: DNA damage checkpoint [IMPLink to PubMed article]
    telomere maintenance via recombination [IGILink to PubMed article]
    DNA metabolic process [TASLink to PubMed article]
    chromatin silencing at telomere [IMPLink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLKLIVNGC EAPDDYKLLR TTINTVASLR KTAILRFNSE RLTIISTPKS SLNSSNNGTI  60
   61 LRGDTGQLWC TIPHDVFRLY TVISARELNT ITMECNCDSL LSVFKRYDRV MNQGSSSNMT 120
  121 IKLQSMPEWN TNNGTLSGGT AGGVDTTSKP NPICALGITF EEIVHTSGPN DAIVMNGGVD 180
  181 EHNGLPTTVG TGNLLASNKV IMHSFKVPVK LLFRAQDTRI QEPMINYIQL MMYKLPPISG 240
  241 EFGSAFHGFI RRVERYSNVN HIHLMGVKKK EHGNEGDDVE LKIIVNELDW HLEICWNGPL 300
  301 DSVIQRQEGL TDNPSQNQHI DTDGRQEEGS LPIIEADKPM SSLYTNTRDR EMEENIRYDE 360
  361 DLLRIEDSSI ADTRGNIYTA DTSGDTEFND ISVMVEKAEQ ESSSTHEVII RCKDWKVCSK 420
  421 LYAAFEEVVL AISHDESCVF HCSLDRGSLE DSEDVEKPRE RGQIIYYIAR SKGL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) DDC1 MEC3
    View Details Krogan NJ, et al. (2006) ATG33 BUB1 CUL3 GUT1 ISM1 MEC3 MLC1 MYO2 MYO4 RGA1 RSB1 SAT4 SHE2 SHE3 SHE4 SRC1 SSH4 STT4 TOF2 TVP18 YDR186C YOL098C
    View Details Ho Y, et al. (2002) AHP1 DDC1 DNL4 LIF1 MEC3 RAD17 RFC4 SUV3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen MEC3 LIP2 2 Unpublished Fields Lab Data
    View Screen MEC3 ATG16 2 Uetz P, et al. (2000)
    View Screen MEC3 TFB1 2 Unpublished Fields Lab Data
    View Screen MEC3 TFB3 2 Unpublished Fields Lab Data
    View Screen MEC3 RAD17 2 Unpublished Fields Lab Data
    View Screen RAD17 MEC3 2 Uetz P, et al. (2000)
    View Screen MEC3 MCM10 2 Unpublished Fields Lab Data
    View Screen MEC3 ALY2 2 Unpublished Fields Lab Data
    View Screen MEC3 EST1 1 Unpublished Fields Lab Data
    View Screen MEC3 GIP1 1 Unpublished Fields Lab Data
    View Screen MEC3 MAP1 1 Unpublished Fields Lab Data
    View Screen MEC3 IWR1 1 Unpublished Fields Lab Data
    View Screen MEC3 NBP1 1 Unpublished Fields Lab Data
    View Screen MEC3 KGD2 1 Unpublished Fields Lab Data
    View Screen MEC3 RTN1 1 Unpublished Fields Lab Data
    View Screen MEC3 MLH1 1 Unpublished Fields Lab Data
    View Screen MEC3 YDR239C 1 Unpublished Fields Lab Data
    View Screen MEC3 ZIM17 1 Unpublished Fields Lab Data
    View Screen MEC3 AAD14 1 Unpublished Fields Lab Data
    View Screen MEC3 SPS4 1 Unpublished Fields Lab Data
    View Screen MEC3 PRP3 1 Unpublished Fields Lab Data
    View Screen MEC3 FRT1 1 Unpublished Fields Lab Data
    View Screen MEC3 KSS1 1 Unpublished Fields Lab Data
    View Screen MEC3 NUP57 1 Unpublished Fields Lab Data
    View Screen MEC3 MSC3 1 Unpublished Fields Lab Data
    View Screen MEC3 CCC1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..474] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
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