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Protein Overview: PUT3

General Information:
Name(s) found: PUT3 / YKL015W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binuclear cluster domain [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 979 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article]
    Biological Process: proline catabolic process [IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IDALink to PubMed article]
    Molecular Function: specific RNA polymerase II transcription factor activity [IDALink to PubMed article]
    transcription activator activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTDQGSRHS IQSKQPAYVN KQPQKRQQRS SVACLSCRKR HIKCPGGNPC QKCVTSNAIC  60
   61 EYLEPSKKIV VSTKYLQQLQ KDLNDKTEEN NRLKALLLER PVSVRGKDNS DDDERHINNA 120
  121 PSSDTLEVSS APAAPIFDLM SNSNTASDND NDDDNSNRIT NNRSYDHSLE KYYKKAISIF 180
  181 KQPANANGEN GNGANGHEDD DEDDEEISTN FAQRSGRLIE SHNGFHYFVG SSSMTLFGLE 240
  241 IQSLVTKYIS VKNFRPLPIN TKNKILNSNL NPAISSFINS NNYLFSSYNF LNPISTIVNL 300
  301 NSINDNLSPL MFKIILKSDT DGSSGQEEVI QFQLPSYNYT KLLIDCFINY NDGCFYFFNE 360
  361 GLVKCGINKL YLENKWLYYD NTKKALDNEN DPILQAVWFC KILLILAVGE MYLGSINNEM 420
  421 LKNYSNQPKL PGSKFFQMGS KIFNCLFSSE RLENVTKKGG IEVLLLYAFF LQVADYTLAS 480
  481 YFYFGQALRT CLILGLHVDS QSDTLSRYEI EHHRRLWWTV YMFERMLSSK AGLPLSFTDY 540
  541 TISTALPADI DDETIEEKNS HYVFRKAELI SNCVTIVKIN AQILSKLYQR QPETNIIITL 600
  601 KVVIKQLLEW RNNLSDSLQV DFTQKDEDFK ISRLSTNMFT EYFQGINLAV RPLLFHFASI 660
  661 QLKRFKTSNT FVNLQNYSAT ISSLLTCSLH ASVNTIRSLW SLLQNSMLAM FSYMDREYLF 720
  721 TSSCTLLLFN TAFGIHEQTL YHLDHSLEIF TQMRNLGNIP AGLRRAQLLT LMANLDFHGI 780
  781 MNDLITKYND ILKFDSMNCE NDNIVEDSNE PKRETEKCKP HKDGDRIDPS IIDCDKSNTN 840
  841 TNMIKNESIS NIVSILPEGA KPTLTDYSNG NNDVNDINVN NSEPSTFFDI ITASLENSYQ 900
  901 TTLTEKGSQV MEKNMDQLDS VHNLNDDDLQ QLLEDLGNID HSDEKLWKEI TDQAMWLGNT 960
  961 MDPTAAAGSE IDFTDYLGP

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ENP2 ESF1 PUT3 RRP3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PUT3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..132] PSI-BLAST 366.927757 PUT3
    2 View Details [133..813] MSA 8.111977 View MSA. No confident structure predictions are available.
    3 View Details [814..979] deduced N/A No confident structure predictions are available.
    4 View Details [454..564] Pfam 26.69897 No description for PF04082.9 was found. No confident structure predictions are available.
    5 View Details [565..778] MSA 2.250993 View MSA. No confident structure predictions are available.
    6 View Details [779..979] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.56444258780502 bayes_pls_golite062009
  • DNA binding
    		•  4.26146437716972 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.17369933547911 bayes_pls_golite062009
  • transcription factor activity
    		•  3.049435548132 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.98081393153291 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.93914501897006 bayes_pls_golite062009
  • binding
    		•  2.91929847152301 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  2.44382866473054 bayes_pls_golite062009
  • transcription activator activity
    		•  2.24483536326713 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.34861813464065 bayes_pls_golite062009
  • DNA binding
    		•  4.03985756894684 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.97978190843512 bayes_pls_golite062009
  • transcription factor activity
    		•  2.87348461329489 bayes_pls_golite062009
  • binding
    		•  2.82809978070212 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.77469997789536 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.70904317608141 bayes_pls_golite062009
  • transcription activator activity
    		•  2.1512787242583 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  2.08956709478484 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.76

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle