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Protein Overview: PBS2

General Information:
Name(s) found: PBS2 / YJL128C [SGD]
Description(s) found:
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  • gi|83305209|sp|P08018.3|PBS2_YEAST RecName: Full=MAP kinase kinase PBS2; AltName: Full=Polymyxin B resistance protein 2; AltName: Full=Suppressor of fluoride sensitivity 4 [NCBI NR]
  • gi|6322333|ref|NP_012407.1| MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress; Pbs2p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S56909 polymyxin B resistance protein PBS2 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1008328|emb|CAA89423.1| PBS2 [Saccharomyces cerevisiae] [NCBI NR]
  • MAP kinase kinase PBS2 OS=Saccharomyces cerevisiae GN=PBS2 PE=1 SV=3 [Swiss-Prot]
  • PBS2 Tyrosine protein kinase of the MAP kinase kinase family [mips]
  • MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress; plays a role in regulating Ty1 transposition [SGD]
  • PBS2, Chr X from 177795-179801, reverse complement [yeast_orfs2]
  • Chr X from 177795-179801, reverse complement [yeastorf3.fasta]
  • Chr X from 179801-177795, reverse complement [yeastorf5.fasta]
  • PBS2 SGDID:S0003664, Chr X from 180021-178015, reverse complement, Verified ORF [yeastflysequest.fasta]
  • MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress [Saccharomyces cerevisiae]gi|1008328|emb|CAA89423.1| PBS2 [Saccharomyces cerevisiae]gi|1078200|pir||S56909 polymyxin B resi [nrdb_11152004_Chlamydomonas]
  • PBS2 SGDID:S000003664, Chr X from 180021-178015, reverse complement, Verified ORF, "MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • PBS2 SGDID:S000003664, Chr X from 180100-178094, reverse complement, Verified ORF, "MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress" [yeast-contam.fasta]
  • PBS2 SGDID:S000003664, Chr X from 180100-178094, reverse complement, Verified ORF, "MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress; plays a role in regulating Ty1 transposi [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • PBS2 SGDID:S000003664, Chr X from 180099-178093, reverse complement, Verified ORF, "MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress; plays a role in regulating Ty1 transposi [yeast-200209-contam.fasta]
  • MAP kinase kinase PBS2 (Polymyxin B resistance protein 2) (Suppressor of fluoride sensitivity 4) [nr-271106-contam.fasta]
  • PBS2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress; Pbs2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • PBS2 SGDID:S000003664, Chr X from 180099-178093, reverse complement, Verified ORF, "MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress; plays a role in regulating Ty1 transposition" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 668 amino acids

    Gene Ontology:
    Cellular Component: cellular bud tip [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    cellular bud neck [IDALink to PubMed article]
    Biological Process: osmosensory signaling pathway [IMPLink to PubMed article]
    nuclear translocation of MAPK involved in osmosensory signaling pathway [IMPLink to PubMed article]
    actin filament organization [IMPLink to PubMed article]
    protein amino acid phosphorylation [IMPLink to PubMed article]
    activation of MAPK activity involved in osmosensory signaling pathway [IMPLink to PubMed article]
    hyperosmotic response [IMPLink to PubMed article]
    Molecular Function: MAP kinase kinase activity [IMPLink to PubMed article][ISSLink to PubMed article]
    MAP-kinase scaffold activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDKFANLSL HEKTGKSSIQ LNEQTGSDNG SAVKRTSSTS SHYNNINADL HARVKAFQEQ  60
   61 RALKRSASVG SNQSEQDKGS SQSPKHIQQI VNKPLPPLPV AGSSKVSQRM SSQVVQASSK 120
  121 STLKNVLDNQ ETQNITDVNI NIDTTKITAT TIGVNTGLPA TDITPSVSNT ASATHKAQLL 180
  181 NPNRRAPRRP LSTQHPTRPN VAPHKAPAII NTPKQSLSAR RAVKLPPGGM SLKMPTKTAQ 240
  241 QPQQFAPSPS NKKHIETLSN SKVVEGKRSN PGSLINGVQS TSTSSSTEGP HDTVGTTPRT 300
  301 GNSNNSSNSG SSGGGGLFAN FSKYVDIKSG SLNFAGKLSL SSKGIDFSNG SSSRITLDEL 360
  361 EFLDELGHGN YGNVSKVLHK PTNVIMATKE VRLELDEAKF RQILMELEVL HKCNSPYIVD 420
  421 FYGAFFIEGA VYMCMEYMDG GSLDKIYDES SEIGGIDEPQ LAFIANAVIH GLKELKEQHN 480
  481 IIHRDVKPTN ILCSANQGTV KLCDFGVSGN LVASLAKTNI GCQSYMAPER IKSLNPDRAT 540
  541 YTVQSDIWSL GLSILEMALG RYPYPPETYD NIFSQLSAIV DGPPPRLPSD KFSSDAQDFV 600
  601 SLCLQKIPER RPTYAALTEH PWLVKYRNQD VHMSEYITER LERRNKILRE RGENGLSKNV 660
  661 PALHMGGL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) NBP2 PBS2 PTC1
    View Details Ho Y, et al. (2002) BIO3 FET4 NBP2 PBS2 PDA1 PTC1 SSK2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PBS2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..138] deduced N/A No confident structure predictions are available.
    2 View Details [139..327] ab initio 7.25 No description for 1ldvA was found.
    3 View Details [328..437] PSI-BLAST 357.0 pak1
    4 View Details [438..668] PSI-BLAST 357.0 pak1


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle