YRC Public Data Repository - Protein Structure Prediction

Protein:	PBS2
Organism:	Saccharomyces cerevisiae
Length:	668 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PBS2.

Description	E-value	Query Range	Subject Range
PBS2 - MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activate... gi\|190409378 - gi\|190409378\|gb\|EDV12643.1\| MAP kinase kinase [Saccharomyces cerevisiae RM11-1a] PBS2_YEAST - MAP kinase kinase PBS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PBS2 PE=1 SV=4	634.0	[0..1]	[668..1]
gi\|189442765, gi... - gi\|189442765\|gb\|AAI67167.1\| P21 (CDKN1A)-activated kinase 1 [synthetic construct], gi\|117616152\|gb\|A... gi\|112181194, gi... - gi\|148684379\|gb\|EDL16326.1\| p21 (CDKN1A)-activated kinase 1, isoform CRA_b [Mus musculus], gi\|148684...	475.0	[0..84]	[652..2]
PAK1_BOVIN - Serine/threonine-protein kinase PAK 1 OS=Bos taurus GN=PAK1 PE=1 SV=1	474.0	[0..89]	[652..7]
gi\|109108025, gi... - gi\|109108025\|ref\|XP_001090310.1\| PREDICTED: similar to p21-activated kinase 1 isoform 7 [Macaca mula...	474.0	[0..89]	[652..7]
PAK1 - p21 protein (Cdc42/Rac)-activated kinase 1 gi\|254071369 - gi\|254071369\|gb\|ACT64444.1\| p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) protein [synthe...	473.0	[0..89]	[652..7]
PAK1_RAT - Serine/threonine-protein kinase PAK 1 OS=Rattus norvegicus GN=Pak1 PE=1 SV=3	472.0	[0..89]	[652..7]

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Predicted Domain #1

Region A:
Residues: [1-138]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDKFANLSL HEKTGKSSIQ LNEQTGSDNG SAVKRTSSTS SHYNNINADL HARVKAFQEQ  60
   61 RALKRSASVG SNQSEQDKGS SQSPKHIQQI VNKPLPPLPV AGSSKVSQRM SSQVVQASSK 120
  121 STLKNVLDNQ ETQNITDV

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [139-327]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NINIDTTKIT ATTIGVNTGL PATDITPSVS NTASATHKAQ LLNPNRRAPR RPLSTQHPTR  60
   61 PNVAPHKAPA IINTPKQSLS ARRAVKLPPG GMSLKMPTKT AQQPQQFAPS PSNKKHIETL 120
  121 SNSKVVEGKR SNPGSLINGV QSTSTSSSTE GPHDTVGTTP RTGNSNNSSN SGSSGGGGLF 180
  181 ANFSKYVDI

[Run NCBI BLAST on this sequence.]

Detection Method:	ab initio
Confidence:	7.25
Match:
Description:	No description for 1ldvA was found.

Predicted Domain #3

Region A:
Residues: [328-437]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSGSLNFAGK LSLSSKGIDF SNGSSSRITL DELEFLDELG HGNYGNVSKV LHKPTNVIMA  60
   61 TKEVRLELDE AKFRQILMEL EVLHKCNSPY IVDFYGAFFI EGAVYMCMEY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	357.0
Match:	1f3mC
Description:	pak1
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [438-668]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDGGSLDKIY DESSEIGGID EPQLAFIANA VIHGLKELKE QHNIIHRDVK PTNILCSANQ  60
   61 GTVKLCDFGV SGNLVASLAK TNIGCQSYMA PERIKSLNPD RATYTVQSDI WSLGLSILEM 120
  121 ALGRYPYPPE TYDNIFSQLS AIVDGPPPRL PSDKFSSDAQ DFVSLCLQKI PERRPTYAAL 180
  181 TEHPWLVKYR NQDVHMSEYI TERLERRNKI LRERGENGLS KNVPALHMGG L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	357.0
Match:	1f3mC
Description:	pak1
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits