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View Structure Prediction Details

Protein: PBS2
Organism: Saccharomyces cerevisiae
Length: 668 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PBS2.

Description E-value Query
Range
Subject
Range
PBS2 - MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activate...
gi|190409378 - gi|190409378|gb|EDV12643.1| MAP kinase kinase [Saccharomyces cerevisiae RM11-1a]
PBS2_YEAST - MAP kinase kinase PBS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PBS2 PE=1 SV=4
634.0 [0..1] [668..1]
gi|189442765, gi... - gi|189442765|gb|AAI67167.1| P21 (CDKN1A)-activated kinase 1 [synthetic construct], gi|117616152|gb|A...
gi|112181194, gi... - gi|148684379|gb|EDL16326.1| p21 (CDKN1A)-activated kinase 1, isoform CRA_b [Mus musculus], gi|148684...
475.0 [0..84] [652..2]
PAK1_BOVIN - Serine/threonine-protein kinase PAK 1 OS=Bos taurus GN=PAK1 PE=1 SV=1
474.0 [0..89] [652..7]
gi|109108025, gi... - gi|109108025|ref|XP_001090310.1| PREDICTED: similar to p21-activated kinase 1 isoform 7 [Macaca mula...
474.0 [0..89] [652..7]
PAK1 - p21 protein (Cdc42/Rac)-activated kinase 1
gi|254071369 - gi|254071369|gb|ACT64444.1| p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) protein [synthe...
473.0 [0..89] [652..7]
PAK1_RAT - Serine/threonine-protein kinase PAK 1 OS=Rattus norvegicus GN=Pak1 PE=1 SV=3
472.0 [0..89] [652..7]

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Predicted Domain #1
Region A:
Residues: [1-138]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDKFANLSL HEKTGKSSIQ LNEQTGSDNG SAVKRTSSTS SHYNNINADL HARVKAFQEQ  60
   61 RALKRSASVG SNQSEQDKGS SQSPKHIQQI VNKPLPPLPV AGSSKVSQRM SSQVVQASSK 120
  121 STLKNVLDNQ ETQNITDV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.611 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.611 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.554 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.553 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.553 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.466 d.110.4 SNARE-like
View Download 0.466 d.110.4 SNARE-like
View Download 0.443 d.110.4 SNARE-like
View Download 0.443 d.110.4 SNARE-like
View Download 0.440 a.72.1 Functional domain of the splicing factor Prp18

Predicted Domain #2
Region A:
Residues: [139-327]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NINIDTTKIT ATTIGVNTGL PATDITPSVS NTASATHKAQ LLNPNRRAPR RPLSTQHPTR  60
   61 PNVAPHKAPA IINTPKQSLS ARRAVKLPPG GMSLKMPTKT AQQPQQFAPS PSNKKHIETL 120
  121 SNSKVVEGKR SNPGSLINGV QSTSTSSSTE GPHDTVGTTP RTGNSNNSSN SGSSGGGGLF 180
  181 ANFSKYVDI

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 7.25
Match:
Description: No description for 1ldvA was found.

Predicted Domain #3
Region A:
Residues: [328-437]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSGSLNFAGK LSLSSKGIDF SNGSSSRITL DELEFLDELG HGNYGNVSKV LHKPTNVIMA  60
   61 TKEVRLELDE AKFRQILMEL EVLHKCNSPY IVDFYGAFFI EGAVYMCMEY 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 357.0
Match: 1f3mC
Description: pak1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [438-668]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDGGSLDKIY DESSEIGGID EPQLAFIANA VIHGLKELKE QHNIIHRDVK PTNILCSANQ  60
   61 GTVKLCDFGV SGNLVASLAK TNIGCQSYMA PERIKSLNPD RATYTVQSDI WSLGLSILEM 120
  121 ALGRYPYPPE TYDNIFSQLS AIVDGPPPRL PSDKFSSDAQ DFVSLCLQKI PERRPTYAAL 180
  181 TEHPWLVKYR NQDVHMSEYI TERLERRNKI LRERGENGLS KNVPALHMGG L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 357.0
Match: 1f3mC
Description: pak1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle