Protein Overview: PFK26

General Information:
Name(s) found:	PFK26 / YIL107C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|728742\|sp\|P40433.1\|6P21_YEAST RecName: Full=6-phosphofructo-2-kinase 1; Short=6PF-2-K 1; AltName: Full=Phosphofructokinase 2 I [NCBI NR] gi\|6322084\|ref\|NP_012159.1\| 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A; Pfk26p [Saccharomyces cerevisiae [NCBI NR] pir\|\|S48465 6-phosphofructo-2-kinase (EC 2.7.1.105) PFK26 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|558699\|emb\|CAA86273.1\| 6-phosphofructo-2-kinase [Saccharomyces cerevisiae] [NCBI NR] gi\|51013089\|gb\|AAT92838.1\| YIL107C [Saccharomyces cerevisiae] [NCBI NR] 6-phosphofructo-2-kinase 1 OS=Saccharomyces cerevisiae GN=PFK26 PE=1 SV=1 [Swiss-Prot] PFK26 6-phosphofructose-2-kinase, isozyme 1 [mips] 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A [SGD] PFK26, Chr IX from 163275-165758, reverse complement [yeast_orfs2] Chr IX from 163275-165758, reverse complement [yeastorf3.fasta] Chr IX from 165758-163275, reverse complement [yeastorf5.fasta] (P40433) 6-phosphofructo-2-kinase 1 (EC 2.7.1.105) (Phosphofructokinase 2 I) (6PF-2-K 1) [4932.FASTACCERV.txt] PFK26 SGDID:S0001369, Chr IX from 165758-163275, reverse complement, Verified ORF [yeastflysequest.fasta] 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A [Saccharomyces cerevisiae]gi\|51013089\|gb\|AAT92838.1\| YIL107C [nrdb_11152004_Chlamydomonas] PFK26 SGDID:S000001369, Chr IX from 165758-163275, reverse complement, Verified ORF, "6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation i [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] PFK26 SGDID:S000001369, Chr IX from 165758-163275, reverse complement, Verified ORF, "6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation i [SGD_S-cerevisiae_na_05-08-2009_con_reversed.fasta] 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A; Pfk26p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YIL107C [Saccharomyces cerevisiae] [nr-271106-contam.fasta] 6-phosphofructo-2-kinase [Saccharomyces cerevisiae] [nr-271106-contam.fasta] 6-phosphofructo-2-kinase 1 (Phosphofructokinase 2 I) (6PF-2-K 1) [nr-271106-contam.fasta] PFK26 SGDID:S000001369, Chr IX from 165758-163275, reverse complement, Verified ORF, "6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A" [yeast-bovrabprots.fasta] PFK26 SGDID:S000001369, Chr IX from 165758-163275, reverse complement, Verified ORF, "6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A" [scerevisihumanrev.fasta] [chemostatdb.fasta] 6-phosphofructo-2-kinase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PFK26 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] PFK26 SGDID:S000001369, Chr IX from 165761-163278, Genome Release 64-1-1, reverse complement, Verified ORF, "6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A" [yeast-030211-contam.fasta] PFK26 SGDID:S000001369, Chr IX from 165761-163278, Genome Release 64-2-1, reverse complement, Verified ORF, "6-phosphofructo-2-kinase; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A" [20141208_orf_trans.fasta] YIL107C SGDID:S000001369, Chr IX from 165761-163278, Genome Release 64-1-1, reverse complement, Verified ORF, "6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	827 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IC]
Biological Process:	fructose 2,6-bisphosphate metabolic process [NAS] regulation of glycolysis [NAS]
Molecular Function:	6-phosphofructo-2-kinase activity [IDA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKPVDFSET SPVPPDIDLA PTQSPHHVAP SQDSSYDLLS RSSDDKIDAE KGPHDELSKH  60
   61 LPLFQKRPLS DTPISSNWNS PGITEENTPS DSPENSATNL KSLHRLHIND ETQLKNAKIP 120
  121 TNDTTDYMPP SDGANEVTRI DLKDIKSPTR HHKRRPTTID VPGLTKSKTS PDGLISKEDS 180
  181 GSKLVIVMVG LPATGKSFIT NKLSRFLNYS LYYCKVFNVG NTRRKFAKEH GLKDQDSKFF 240
  241 EPKNADSTRL RDKWAMDTLD ELLDYLLEGS GSVGIFDATN TSRERRKNVL ARIRKRSPHL 300
  301 KVLFLESVCS DHALVQKNIR LKLFGPDYKG KDPESSLKDF KSRLANYLKA YEPIEDDENL 360
  361 QYIKMIDVGK KVIAYNIQGF LASQTVYYLL NFNLADRQIW ITRSGESEDN VSGRIGGNSH 420
  421 LTPRGLRFAK SLPKFIARQR EIFYQNLMQQ KKNNENTDGN IYNDFFVWTS MRARTIGTAQ 480
  481 YFNEDDYPIK QMKMLDELSA GDYDGMTYPE IKNNFPEEFE KRQKDKLRYR YPGIGGESYM 540
  541 DVINRLRPVI TELERIEDNV LIITHRVVAR ALLGYFMNLS MGIIANLDVP LHCVYCLEPK 600
  601 PYGITWSLWE YDEASDSFSK VPQTDLNTTR VKEVGLVYNE RRYSVIPTAP PSARSSFASD 660
  661 FLSRKRSNPT SASSSQSELS EQPKNSVSAQ TGSNNTTLIG SNFNIKNENG DSRIPLSAPL 720
  721 MATNTSNNIL DGGGTSISIH RPRVVPNQNN VNPLLANNNK AASNVPNVKK SAATPRQIFE 780
  781 IDKVDEKLSM LKNKSFLLHG KDYPNNADNN DNEDIRAKTM NRSQSHV

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		PFK26 TRX2 YGR031W
View Details	Qiu et al. (2008)		GLK1 PFK26

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#25 Asynchronous Prep3-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	PFK26	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..91]	MSA	1.012988	View MSA. No confident structure predictions are available.
2	View Details	[92..394]	PSI-BLAST	966.9691	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain
3	View Details	[395..661]	PSI-BLAST	966.9691	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain
4	View Details	[662..827]	deduced	N/A	No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: PFK26

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: