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View Structure Prediction Details

Protein: PFK26
Organism: Saccharomyces cerevisiae
Length: 827 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PFK26.

Description E-value Query
Range
Subject
Range
6P21_YEAST - 6-phosphofructo-2-kinase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PFK26 PE=1 SV...
PFK26 - 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligib...
0.0 [1..827] [1..827]
F262_RAT - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 OS=Rattus norvegicus GN=Pfkfb2 PE=1 SV=1
0.0 [171..697] [29..522]
gi|148707789, gi... - gi|74145062|dbj|BAE27404.1| unnamed protein product [Mus musculus], gi|34147045|ref|NP_032851.2| 6-p...
0.0 [173..688] [30..514]
F262_BOVIN - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 OS=Bos taurus GN=PFKFB2 PE=1 SV=2
0.0 [169..693] [25..518]
gi|105153, gi|45... - gi|4505745|ref|NP_002616.1| 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 [Homo sapiens], gi...
0.0 [131..643] [2..471]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [136..696] [3..516]

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Predicted Domain #1
Region A:
Residues: [1-91]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKPVDFSET SPVPPDIDLA PTQSPHHVAP SQDSSYDLLS RSSDDKIDAE KGPHDELSKH  60
   61 LPLFQKRPLS DTPISSNWNS PGITEENTPS D

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [92-394]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPENSATNLK SLHRLHINDE TQLKNAKIPT NDTTDYMPPS DGANEVTRID LKDIKSPTRH  60
   61 HKRRPTTIDV PGLTKSKTSP DGLISKEDSG SKLVIVMVGL PATGKSFITN KLSRFLNYSL 120
  121 YYCKVFNVGN TRRKFAKEHG LKDQDSKFFE PKNADSTRLR DKWAMDTLDE LLDYLLEGSG 180
  181 SVGIFDATNT SRERRKNVLA RIRKRSPHLK VLFLESVCSD HALVQKNIRL KLFGPDYKGK 240
  241 DPESSLKDFK SRLANYLKAY EPIEDDENLQ YIKMIDVGKK VIAYNIQGFL ASQTVYYLLN 300
  301 FNL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 966.9691
Match: 1bif__
Description: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [395-661]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADRQIWITRS GESEDNVSGR IGGNSHLTPR GLRFAKSLPK FIARQREIFY QNLMQQKKNN  60
   61 ENTDGNIYND FFVWTSMRAR TIGTAQYFNE DDYPIKQMKM LDELSAGDYD GMTYPEIKNN 120
  121 FPEEFEKRQK DKLRYRYPGI GGESYMDVIN RLRPVITELE RIEDNVLIIT HRVVARALLG 180
  181 YFMNLSMGII ANLDVPLHCV YCLEPKPYGI TWSLWEYDEA SDSFSKVPQT DLNTTRVKEV 240
  241 GLVYNERRYS VIPTAPPSAR SSFASDF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 966.9691
Match: 1bif__
Description: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [662-827]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSRKRSNPTS ASSSQSELSE QPKNSVSAQT GSNNTTLIGS NFNIKNENGD SRIPLSAPLM  60
   61 ATNTSNNILD GGGTSISIHR PRVVPNQNNV NPLLANNNKA ASNVPNVKKS AATPRQIFEI 120
  121 DKVDEKLSML KNKSFLLHGK DYPNNADNND NEDIRAKTMN RSQSHV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle