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Protein Overview: AGE2

General Information:
Name(s) found: AGE2 / YIL044C [SGD]
Description(s) found:
Found 22 descriptions.
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  • ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 298 amino acids

    Gene Ontology:
    Cellular Component: clathrin-coated vesicle [IDALink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [IGILink to PubMed article][ISSLink to PubMed article]
    intra-Golgi vesicle-mediated transport [IGILink to PubMed article][ISSLink to PubMed article]
    Molecular Function: ARF GTPase activator activity [IDALink to PubMed article][IGILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTSVPVKKA LSALLRDPGN SHCADCKAQL HPRWASWSLG VFICIKCAGI HRSLGTHISK  60
   61 VKSVDLDTWK EEHLVKLIQF KNNLRANSYY EATLADELKQ RKITDTSSLQ NFIKNKYEYK 120
  121 KWIGDLSSIE GLNDSTEPVL HKPSANHSLP ASNARLDQSS NSLQKTQTQP PSHLLSTSRS 180
  181 NTSLLNLQVS SLSKTTSNTS VTSSATSIGA ANTKTGNRVG EFGQRNDLKK SILSLYSKPS 240
  241 AQTQSQNSFF TSTTPQPCNT PSPFVNTGIT ATNNNSMNSN SSSNISLDDN ELFKNVWS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) AGE2 GLO3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data AGE2 Huh WK, et al. (2003)
    View Data AGE2 and CHC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..130] PSI-BLAST 149.37734 Pyk2-associated protein beta; Pyk2-associated protein beta ARF-GAP domain
    2 View Details [131..298] MSA 18.097997 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.47

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle