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Protein Overview: VPS72

General Information:
Name(s) found: VPS72 / YDR485C [SGD]
Description(s) found:
Found 13 descriptions.
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  • Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 810 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Swr1 complex [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: chromatin remodeling [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    histone exchange [IMPLink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article]
    Molecular Function: histone binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTNRSETEA NSQCTMSDEG ADKSLDTNTE FIIQTRSRRS NAGNKLQKLL EQELRDIEST  60
   61 KRQISSYKNG NDDEEDEIGL LFQEDEDDED FEMMAKDDDD EGEEKEDETQ SIRKEPSQAS 120
  121 SEQAADDLMF SSSESEDSSN ENDEDAEEKE IRRQELLSRK KRNKRLQKGP VVIKKQKPKP 180
  181 KSGEAIPRSH HTHEQLNAET LLLNTRRTSK RSSVMENTMK VYEKLSKAEK KRKIIQERIR 240
  241 KHKEQESQHM LTQEERLRIA KETEKLNILS LDKFKEQEVW KKENRLALQK RQKQKFQPNE 300
  301 TILQFLSTAW LMTPAMELED RKYWQEQLNK RDKKKKKYPR KPKKNLNLGK QDASDDKKRE 360
  361 SEESIKNDGD VNSLGENSSS VHNQKRIEET STNDTVEGES SPDAAVSRVN SDELKPTALP 420
  421 DVTLDAIANK QSTVDEAPNS QPQKNIITNE QKITNVGEPI QNLHNEEIKD EMVSALESRE 480
  481 NTFENSSPAA QVVSQRDNSA TPTPSNSTGT EDTILISPDT DIKGEPEPCL KTEGIENLSH 540
  541 NVPQETKSNT DVSFLKQVTF TDHPQVAIID TEESPSKKDT ANVDESSAEN SLSTQTYEGP 600
  601 EQLTSRNFVT LYDFPNAPPN LKDFNTNLFG DRWSYTNGLS ATQRPQDMKT VFHSILPSPP 660
  661 QSSVPSPTVD ISLDLSALAN FPSFGEYDKK IVHQINTEIN KDLEIKIKTQ PPTGVFLANG 720
  721 IRKKCLITNK ECQYFDPRTG VPYSDVEAYK IIQRIQDPIS KEEGRSDIKR DETTNEDSDD 780
  781 QVRFKWFGFK NGGIYLDLSQ RPAKGVPEGF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SWC4 No Comments Hazbun TR, et al. (2003)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..96] ORFEUS 7.73 No description for 1l8mA was found.
    2 View Details [97..175] ORFEUS 7.73 No description for 1l8mA was found.
    3 View Details [176..245] ORFEUS 7.73 No description for 1l8mA was found.
    4 View Details [246..321] ORFEUS 7.73 No description for 1l8mA was found.
    5 View Details [322..405] ORFEUS 14.05 No description for 1ldvA was found.
    6 View Details [406..738] ORFEUS 7.45 Fibrinogen
    7 View Details [739..810] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

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    Created and Maintained by: Michael Riffle