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Protein Overview: PKH3

General Information:
Name(s) found: PKH3 / YDR466W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 898 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: MAPKKK cascade involved in cell wall biogenesis [IGILink to PubMed article]
    Molecular Function: protein kinase activity [ISSLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSRKRSPHD FIFKEELGHG SYSTVFKALD KKSPNKIYAI KVCSKKHIIK EAKVKYVTIE  60
   61 KNTMNLLAQK HHAGIIKLYY TFHDEENLYF VLDFAPGGEL LSLLHKMGTF NDIWTRHFTA 120
  121 QLIDALEFIH SHGIIHRDLK PENVLLDRDG RLMITDFGAA ATIDPSLSGD SAKFNSDSNG 180
  181 SKDNQNCASF VGTAEYVSPE LLLYNQCGYG SDIWALGCMI YQFVQGQPPF RGENELKTFE 240
  241 KIVALDYPWG PNNRINNSTS PINPLVINLV QKILVIEVNE RISLEQIKRH PYFSKVDWND 300
  301 KIKIWRGIWQ SQGQSLQQTT LGLPNIPQNI LPTRQLHVID TPARSIQITK QKRKKPTKIS 360
  361 NTTSSIVVWR KRLGISTGKD DLGTVPSTTP AVTAPNDTNV LTNTAAHSTA NIALPPNSQS 420
  421 NQVKRAQLVA PNRIPPKVPV INDNVRNKSI PRTKPNVPPL QTSSIPQKLS TSSASSALSA 480
  481 PSTEIRNQDL THTLDGRNSI DIHVLKQDYV FIYGIPYEHE GPAMSLNSYN KIDNDLITSL 540
  541 VAQHKEELKN SESFLQVLTL KKSGMLSYKN TVMEGNDDQE NKEHQMANIE DTDLSMYDFE 600
  601 FNELTRKGFL ILEKYKNRIW FISLPSYSTL SKIPFNAVKS STINNNENWV DCFFRARQLL 660
  661 EEKQILDKIS NVSFDSKASS EPSSPPPISR KERPLSIGNN VTTLSYTAKN GSQNNAPQND 720
  721 NVGEEKPFRI PSSTKDRPGA NSTPSSRHPR VLSSNNAGET PKKMNGRLPN SAPSTNTYTN 780
  781 GSVPAFNHRP STNVGNNKHN ILTSKKQGSS VFSPSSSTTK PQIKTTGYRQ PTPSPPLPQM 840
  841 EFPTTREKYS APSNMVISSS RYEVLHTLNN SQTNFDREIA SRGASAAFRS LQKSKKKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PKH3 YPR084W
    View Details Krogan NJ, et al. (2006) BIK1 ERG29 PKH3 RTR1 STB4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..58]
    [78..94]    		 PSI-BLAST 497.0103 cAMP-dependent PK, catalytic subunit
    2 View Details [59..77]
    [95..268]    		 PSI-BLAST 497.0103 cAMP-dependent PK, catalytic subunit
    3 View Details [269..405] PSI-BLAST 2.522879 Heavy meromyosin subfragment
    4 View Details [406..644] PSI-BLAST 2.522879 Heavy meromyosin subfragment
    5 View Details [645..898] ORFEUS 12.41 RBP1


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle