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Protein Overview: MSN5

General Information:
Name(s) found: MSN5 / YDR335W [SGD]
Description(s) found:
Found 20 descriptions.
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  • Karyopherin involved in nuclear import and export; shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p, Far1p, and Pho4p; cargo dissociation involves binding to RanGTP [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1224 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    Biological Process: protein export from nucleus [IDALink to PubMed articleLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    importin-alpha export receptor activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [NCBI BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSTGASQIV SALDVIYSPK SNNSQRQEAQ KFLDEVKLCS ESPFWGYEIA LQNPTNSILK  60
   61 YFGLGLLDHA VKKNWNDYDE GKRVALRKWV MELNFGVQDY DTRYIKEKLA TLWVEVAKRT 120
  121 WGEALKQTNP TEEQLLTSWV DMDNNLFELW NINQSSRELA LIIFRILFED VFLLDDLIVL 180
  181 KRMTVIQPLC VMIVCPIEVF AIKYKFSDKW TKFKANEEGW FSVWIPELNN ALQQNNSEYI 240
  241 IRLLETLKTC LNWPLTEVIV RNDVLSSLLT CLSSNIPRAQ SMALDSIHIL LTRPYSNESH 300
  301 YQMTIDRVFD NMDLLDSVYE SLLFDPTDDI DETKYPIIKK FVDMISCLYV CVPKIKETNG 360
  361 QIQKYFKLVL KTTYNPSLIV SGLTLDLWCT CLRNDEYLPK LEKYVIPDLL QFAADALVYY 420
  421 EQIDGHISKK FAEIDFQSKS EFQTFCSTYR KRIRDIIRLI SCVELDLTYD WLNNRLNNYF 480
  481 SSPFGQQVLS STFLDHKLEP YLGALSQYMI VECFINGCIR WKIWYPTGDD YDEKLDSILQ 540
  541 KLEILSNQLI ALNLREPLLL KKQIQNFALF LTMLKDNVLF TLLEKIITSA TMDYPEINLE 600
  601 ERGAESDAVR DLRYACGIEL NRMALLMPES LKKIYPDLES VIARIMPNLS YHEKISFKSF 660
  661 LLIIVLKSSL DMKEERFAAI VDPELLAWSD KTTVVGLSDL HWFMERLGIV QIAEYFQRRD 720
  721 IDENSDLLSI PIDDEGKELK SELTKRWQSL FPVRATRMFI HYSMQSIKTD EEFKMLQDLW 780
  781 RPRIVPILPY ITRLLYQLQS YHDPDNWKGL PTVVQSFVKY STIERFWEAG ASNKSKDEFI 840
  841 DEHMKAMQTL RDFADSVGHI IRYTREYTLL VLSAISSLGS VFYLLDESPD LLLNSIAIFK 900
  901 PGSNEISPGV STHGWKHIMN IAIRPILKGC PKDCLGKFMP AFLPKLFEIL DLLLCQKWSS 960
  961 HMNDMDMNPV PTDDDQMTEE ILEENLLRQL TTVVVRIVID CVGQGNANPN SAKSRLNNHQ1020
 1021 MEMRKIIFND LNTLAPFLKL LNHLISFKDT KCSFNSILVM KCCLTSVLNQ NNTVDEYFTF1080
 1081 EVMKNLLLNV LCNSAFKDSF HEALYAFTVI FLTLCKEYPS ARAFLFEISN GYNIDELYRN1140
 1141 LRSVDEYKTQ RALMIDFIDW VKSTSGKEDG NVDHAGDERK RQEKREAILK KANERLIKKN1200
 1201 KENGDMLDDP NIEDGAVGNL FDDN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) GFA1 MSN5 NUM1
    View Details Ho Y, et al. (2002) GAL11 MSN5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen MSN5 SEC9 2 Uetz P, et al. (2000)
    View Screen MSN5 HMO1 2 Uetz P, et al. (2000)
    View Screen MSN5 VTS1 2 Uetz P, et al. (2000)
    View Screen MSN5 HAA1 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MSN5 and NIC96 Huh WK, et al. (2003)
    View Data MSN5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?] [View Top Sequence Alignments]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..253] PSI-BLAST 3.522879 Importin beta
    2 View Details [254..393] MSA 2.061985 View MSA. No confident structure predictions are available.
    3 View Details [394..481] MSA 1.056993 View MSA. Confident ab initio structure predictions are available.
    4 View Details [482..647] MSA 1.02499 View MSA. Confident ab initio structure predictions are available.
    5 View Details [648..1131] MSA 2.016877 View MSA. No confident structure predictions are available.
    6 View Details [1132..1224] MSA 1.003984 View MSA. No confident structure predictions are available.
    7 View Details [906..968] deduced N/A No confident structure predictions are available.
    8 View Details [969..1147] MSA 2.050949 View MSA. No confident structure predictions are available.
    9 View Details [1148..1224] MSA 1.022983 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by:     Michael Riffle