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Protein Overview: YOS9

General Information:
Name(s) found: YOS9 / YDR057W [SGD]
Description(s) found:
Found 31 descriptions.
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  • ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 542 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum lumen [IDALink to PubMed article]
    Biological Process: ER-associated protein catabolic process [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Molecular Function: sugar binding [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQAKIIYALS AISALIPLGS SLLAPIEDPI VSNKYLISYI DEDDWSDRIL QNQSVMNSGY  60
   61 IVNMGDDLEC FIQNASTQLN DVLEDSNEHS NSEKTALLTK TLNQGVKTIF DKLNERCIFY 120
  121 QAGFWIYEYC PGIEFVQFHG RVNTKTGEIV NRDESLVYRL GKPKANVEER EFELLYDDVG 180
  181 YYISEIIGSG DICDVTGAER MVEIQYVCGG SNSGPSTIQW VRETKICVYE AQVTIPELCN 240
  241 LELLAKNEDQ KNASPILCRM PAKSKIGSNS IDLITKYEPI FLGSGIYFLR PFNTDERDKL 300
  301 MVTDNAMSNW DEITETYYQK FGNAINKMLS LRLVSLPNGH ILQPGDSCVW LAEVVDMKDR 360
  361 FQTTLSLNIL NSQRAEIFFN KTFTFNEDNG NFLSYKIGDH GESTELGQIT HSNKADINTA 420
  421 EIRSDEYLIN TDNELFLRIS KEIAEVKELL NEIVSPHEME VIFENMRNQP NNDFELALMN 480
  481 KLKSSLNDDN KVEQINNARM DDDESTSHTT RDIGEAGSQT TGNTESEVTN VAAGVFIEHD 540
  541 EL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..265] MSA 11.02097 View MSA. No confident structure predictions are available.
    2 View Details [266..542] deduced N/A No confident structure predictions are available.
    3 View Details [241..414] deduced N/A No confident structure predictions are available.
    4 View Details [415..542] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.16931544864195 bayes_pls_golite062009
  • receptor activity
    		•  0.66788201077791 bayes_pls_golite062009
  • catalytic activity
    		•  0.282237710666423 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.272927118711356 bayes_pls_golite062009
  • signal transducer activity
    		•  0.26239044372713 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.26239044372713 bayes_pls_golite062009
  • protein binding
    		•  0.192633833830859 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0376900612956657 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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